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73681
Figure 4, supplementary figure 6
Published 2024“…<p dir="ltr"><b>Figure 4: Rapid E2 signaling in the BNST recapitulates the pro-drinking but not anxiolytic effects of ovarian E2 and modulates BNSTCRF neurons. </b>a) Systemic E2 synthesis inhibition in high ovarian E2 mice using the aromatase inhibitor letrozole (LET, 10 mg/kg). b) Effects of LET administration on EtOH consumption (N’s = 13 saline VEH, 19 LET). c) Effects of LET administration on elevated plus maze (EPM) % time spent in the open arms (left) or distance traveled (right; N’s = 15 VEH, 14 LET). d) Intra-BNST infusion of LET (1 μg in 200 nl/side) in high E2 status females. e) Effects of intra-BNST LET on EtOH consumption (N’s = 7 VEH, 6 LET). f) Intra-BNST infusion of E2 (20 pg in 200 nl/side) or membrane-impermeable E2 (mE2, 55 pg in 200 nl/side) in low E2 status females. g) Effects of intra-BNST E2 on EtOH consumption (N’s = 8 VEH, 7 E2). h) Effects of intra-BNST mE2 on EtOH consumption (N’s = 12 VEH, 11 mE2). i) Effects of intra-BNST E2 on EPM % time spent in the open arms (left) or distance traveled (right; N’s = 7 VEH, 8 E2). j) Effects of bath application of E2/mE2 on excitatory synaptic transmission in BNSTCRF neurons during slice electrophysiology recordings in low ovarian E2 status female CRF-CrexAi9 reporters. k) Spontaneous excitatory postsynaptic currents (sEPSCs) maximum delta from % baseline during E2/mE2 wash on (E2 nM: 0.01: N = 2, 2 cells; 1: N = 4, 4 cells; 10: N = 5, 7 cells; 100: N = 4, 4 cells; 1000: N = 3, 5 cells; 100 nM mE2: N = 3, 6 cells; l and m are the same cells). l) Time course of BNSTCRF neurons that displayed increase/decrease/no change in sEPSC frequency and amplitude (m) % change from baseline during E2 application and proportion of responding categories (pie charts). …”
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73682
Data from: Increased Soil Nitrogen Availability Suppresses Annual Soil Respiration in Mixed Temperate Forests Regardless of Acidification
Published 2025“…Soil respiration data included in the data publication are: (1) measurements collected from five fixed collars per plot using a LI-COR 6400 Portable Photosynthesis System equipped with a 6400-09 soil chamber (LI-COR Biosciences, Lincoln, Nebraska, USA); and (2) plot-level annual soil respiration, estimated using the relationship between soil temperature and measured soil respiration. …”
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73683
JAGGED1-NOTCH regulates RPE proliferation and specification.
Published 2013“…Note that in wild type and all indicated mutants, JAGGED1 is expressed in the dorsal distal retina and in (<b>F</b>) also in the E12.0 ventral distal retina and RPE (arrow), in addition to its prominent expression in the lens vesicle. Also note that a dorsal RPE subdomain in <i>Mitf</i> single or <i>Vax1/2/Mitf</i> triple mutants expresses JAGGED1 at both E10.5 and E12.0. …”
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73684
Ingestive behavior, ruminal and blood kinetics in lambs fed cow cheese whey
Published 2021“…Behavioral assessments were made at a 24-hour interval in measurements taken every five minutes. …”
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73685
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73686
Innovative method of impact testing in high temperatures applied in carbon steels
Published 2018“…The specimens are heated in a few seconds (v=32 ºC/s) and held at the test temperature by an electrical circuit controlled by a thermocouple located on the specimen. …”
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73687
MLR-Tregs allospecifically regulate cytotoxic activity in micro-CML generated by purified CD8<sup>+</sup> plus purified autologous CD4<sup>+</sup> responders.
Published 2011“…The lysis of target cells was decreasingly inhibited by decreasing concentrations of modulating MLR-Tregs (points on the right side) as opposed to none seen using control modulators (points on the left side) (** = p<.01; n = 10). …”
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73688
Do economic downturns affect air pollution? Evidence from the global financial crisis
Published 2021“…Our findings reveal that the 2008 crisis decreased the turning point for high-income countries and increased the turning points for middle- and low-income countries. …”
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73689
Detection of the regions of interest from the segmentation results and fitting to the physical models.
Published 2011“…<p>(a) Approach curve: both vertical lines correspond to the beginning () and end () of the electrostatic regime. …”
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73690
Codon Distributions under Environmental Fluctuations
Published 2013“…<div><p>(A) gives the robustness for each codon, that is, the fraction of all possible point mutations that leave the hydrophobicity class unchanged. …”
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73691
The effects of TBEV infection on BALB/c and C57Bl/6 mice.
Published 2013“…Statistically significant (p<0.05) decreases in body weight/temperature at different time points versus the beginning of the experiment are marked by an asterisk (C57Bl/6) or hash (BALB/c).…”
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73692
Turn gain converged rapidly for turns on the mobile robot platform.
Published 2013“…Turn gain was increased when it started too low (A) and decreased when it started too high (B) as needed to reliably track robot heading. …”
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73693
Comparative analysis of mutant worms and chronological aging effects on forced locomotory abilities.
Published 2011“…<p>(A) <i>acr-16</i> (v<sub>//</sub> = 80 µm/s±40 µm/s, N = 28), <i>unc-29</i> (v<sub>//</sub> = 35 µm/s±34 µm/s, N = 26) and <i>unc-29</i>;<i>acr-16</i> mutants (v<sub>//</sub> = 15 µm/s±19 µm/s, N = 22) exhibit reduced velocity when compared to the control population (N2, v<sub>//</sub> = 110 µm/s±50 µm/s, N = 28) in successive electrotactic runs. …”
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73694
Correlational learning rule for regulation of vestibular synapse strength by cerebellar inhibition: transfer of VOR gain from cerebellar cortex to brainstem.
Published 2013“…During training the cerebellum has learnt to produce an inhibitory input modulated in phase with the vestibular input, leading to cancellation which produces a 50% gain decrease (since and , a weight requires ). …”
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73695
Patient sequence evolution in sequence space.
Published 2013“…Sequences with annotated phenotype or tropism are marked with colors (blue for NSI/CCR5 sequences, red for SI/CXCR4). Sequential data points of the same patients are marked in black and connected with a solid line: (A) therapy-experienced patient showing an increase in sequence variability with decreasing CD4+ cell count, (B) therapy-experienced patient with an opposite trend, (C) therapy-naïve patient showing an increase in sequence variability with decreasing CD4+ cell count, (D) therapy-naive patient with a mixed trend. …”
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73696
<i>FANCF</i> shRNA inhibits cell proliferation, increases apoptosis in T-47D and MCF-7 cells.
Published 2013“…<p>(A) Number of viable cells was determined using a hemacytometer after staining dead cells with Trypan Blue. …”
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73697
Co-culture assays of human bronchial epithelial cells (HBEC) and human lung microvascular endothelial cells (HMVEC-L).
Published 2018“…<p>VEGF<sub>165</sub> at 10 ng/mL activated HMVEC-L (A). HMVEC-L treated with VEGF<sub>165</sub> show upregulation of proteases such as cathepsin B and V, matrix metalloprotease (MMP)-7, CD10, and kallikrein 13 (B) as well as a more than 6-fold increase in HB-EGF concentration in the conditioned medium (C). …”
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73698
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73700