Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

TG6-44 treatment decreases A/X31-induced ROS in THP-1 cells. by Juan A. De La Cruz (11154187)

Madrasin decreases transcription of protein-coding genes. by Michael Tellier (8284752)

Sepsis decreases the frequencies of CD4 T cells. by Mian Zhou (339595)

Decreasing Fires in Mediterranean Europe - Fig 7 by Marco Turco (3178641)

Decreasing Fires in Mediterranean Europe - Fig 6 by Marco Turco (3178641)

Decreasing Fires in Mediterranean Europe - Fig 8 by Marco Turco (3178641)

Effects of Cu (5 µM) pretreatment on Hcy-induced decrease in cell viability and LDH release. by Daoyin Dong (424519)

Inhibition of Hsp90 decreased cellular apoptosis. by Raúl Orozco-Díaz (7067624)

Cortactin knockdown results in decreased FA turnover. by Alok Tomar (139282)

RSV increases apoptosis but decreases ROS production. by Cristina Rojas (667363)

Inhibition of NADPH oxidase decreases the oxidative burst. by Pedro Paulo Carneiro (2164114)

Effect of decreasing infectious dose on virus shedding. by Anthony C. Marriott (111070)

MET knockdown decreases MET expression and activation. by Karolin Ebert (7434713)

Decreased CD1d expression by tumor correlates with decreased iNKT-mediated antitumor immunity <i>in vivo</i>. by Laura M. Hix (217695)

Decreased expression of TCA cycle and ETC enzymes in kidneys from rats administered Tl. by Sho Sugahara (11895828)

Overexpression of Lethe decreases ROS production in BMM. by Carlos Zgheib (311460)

IRGM reduced expression efficiently decreases MeV, HCV and HIV-1 viral particles production. by Isabel Pombo Grégoire (193157)

Nsp8 decreases antiviral immune and inflammatory responses and promotes SARS-CoV-2 infection. by Xiaolin Zhang (246784)