Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…<i>N</i>-(4-Bromophenyl)-4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine <b>4f</b>, <i>N</i>-(4-chlorophenyl)-4,6-bis­(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-1,3,5-triazin-2-amine <b>5c</b>, and 4,6-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-<i>N</i>-(4-methoxyphenyl)-1,3,5-triazin-2-amine <b>5d</b> showed promising activity against these cancer cells: <b>4f</b> [(IC₅₀ = 4.53 ± 0.30 μM (MCF-7); 0.50 ± 0.080 μM (HCT-116); and 3.01 ± 0.49 μM (HepG2)]; <b>5d</b> [(IC₅₀ = 3.66 ± 0.96 μM (HCT-116); and 5.42 ± 0.82 μM (HepG2)]; and <b>5c</b> [(IC₅₀ = 2.29 ± 0.92 μM (MCF-7)]. …”

Endoplasmic reticulum calcium decrease via RyR in response to HIV-1 Tat. by John P. Norman (269281)

AS021 activity and Satb2 expression decrease within deep layers at postnatal stages. by Kensuke Tashiro (193459)

“…A similar decrease is observed for βgal, confirming the specificity of the AS021 activity. …”

PDGF-BB-induced NR4A1 expression is decreased after treatment with the NF-κB inhibitor BAY11-7082. by Glenda Eger (636934)

D-4F and L-5F improves blood glucose. by Kristine C. McGrath (8269155)

D-4F and L-5F improves insulin sensitivity. by Kristine C. McGrath (8269155)

Oral administration of TVSE decreases angiogenesis in 4T1 tumors in BALB/c mice. by Hyun Sook Lee (8039876)

A C5a-Immunoglobulin complex in chronic lymphocytic leukemia patients is associated with decreased complement activity by Regina Michelis (2889092)

“…In patients with abnormal C5, basal levels of sC5b-9 and C5a were increased while activities of the CP and of the CP C5-convertase, the immediate C5-upstream complex, were decreased compared to NC and to patients with normal C5. …”

Data Supplement from Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis by Naoharu Takano (15079957)

E3330 attenuates the cisplatin-induced decrease in capsaicin-induced vasodilatation in the rat hindpaw. by Mark R. Kelley (125934)

Flies decrease the level of aggression as the availability of food resource increases. by Rod S. Lim (622045)

Dynasore decreases the production of cholesterol esters from LDL- or AcLDL-derived cholesterol. by Emmanuelle Girard (337171)

Decrease in DA uptake activity in striatal synaptosomes of <i>Ptprz-</i>KO mice. by Akihiro Fujikawa (122649)

The daily pattern of water supply head entries of pairs of rats in 10-minutes epochs. by Piotr Popik (292215)

The treatment with CGS 21680 decreased the mechanical allodynia and thermal hyperalgesia in CFA-injected rats. by Fabrizio Vincenzi (289325)

Fig 7 - by Eric Behle (11426692)

P28 GST enzymatic activity is essential to decrease inflammation in TNBS-induced colitis. by Aurore Sarazin (6162698)

Decreased recruitment of Rac1 and p67^phox to Mtb phagosomes. by Jim Sun (367834)

Reduction of OPL and decreased number of horizontal cells in P18 Oc-deficient mice. by Michaela Kreplova (9239560)

DHA treatment decreases <i>H. pylori</i> adhesion to epithelial gastric cells. by Marta Correia (170478)

“…Pretreatment of <i>H. pylori</i> with DHA significantly decreased the bacterial adherence to AGS cells for treatment of 50 µM and above (*P<0.05). …”