Data_Sheet_5_Circulating exo-miR-154-5p regulates vascular dementia through endothelial progenitor cell-mediated angiogenesis.ZIP by Xue Han (25073)

“…Therefore, miR-154-5p is a promising biomarker and therapeutic strategy for VaD.…”

Table_1_Gender-Specific Effect of 5-HT and 5-HIAA on Threshold Level of Behavioral Symptoms and Sex-Bias in Prevalence of Autism Spectrum Disorder.DOCX by Barnali Chakraborti (3410288)

“…<p>Platelet hyperserotonemia in a subset of Autism Spectrum Disorder (ASD) probands, efficacy of selective serotonin reuptake inhibitors (SSRIs) in reducing behavioral deficits and gender-bias in normal serotonin (5-hydroxy tryptamine or 5-HT) synthesis suggest disruption in stringent regulation of serotonin metabolism in ASD. …”

Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders by Katrin Linda (4245613)

“…Starting from KANSL1-deficient human induced-pluripotent stem cells, both from KdVS patients and genome-edited lines, we identified SOD1 (superoxide dismutase 1), an antioxidant enzyme, to be significantly decreased, leading to a subsequent increase in oxidative stress and autophagosome accumulation. …”

DataSheet_1_Actin Beta-Like 2 as a New Mediator of Proliferation and Migration in Epithelial Ovarian Cancer.docx by Nicole Elisabeth Topalov (11470822)

“…In vitro analyses upon siRNA knockdown of ACTBL2 displayed a significantly reduced cellular viability, proliferation and migration. siRNA knockdown of NFAT5 proved a significant molecular interplay by inducing a downregulation of ACTBL2 with a thus resulting concordant alteration in cellular functions, predominantly reflected in a decreased migratory potential of EOC cells. …”

DataSheet_1_Effects of Alcohol and Cocaine in a Mutant Mouse Model of Predisposition to Post-Traumatic Stress Disorder.pdf by Eleni Paizanis (302275)

“…The spontaneous chronic consumption of either alcohol or cocaine under a 3-week free-choice progressive paradigm of alcohol (3/6/10%) or cocaine (0.2/0.4/0.6 mg/ml), was assessed in VGV transgenic mice, having full 5-HT_2C receptor editing and displaying PTSD-like behaviors. …”

Image_1_A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages.pdf by Jiawen Zhang (586977)

“…In vitro, carvedilol decreased TLR2 expression in RAW 264.7 cells, further reducing KLK5 secretion and LL-37 expression and ultimately inhibiting rosacea-like inflammatory reactions. …”

Image_2_A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages.pdf by Jiawen Zhang (586977)

“…In vitro, carvedilol decreased TLR2 expression in RAW 264.7 cells, further reducing KLK5 secretion and LL-37 expression and ultimately inhibiting rosacea-like inflammatory reactions. …”

Table_5_Zinc Intakes and Health Outcomes: An Umbrella Review.docx by Jin Li (119007)

“…Dose-response analyses revealed that a daily 5 mg increment of zinc would lower the risk of colorectal and esophageal cancer, whereas a large dose of zinc supplementation (daily 100 mg) showed no benefit in reducing prostate cancer risk.…”

Expression of a misfolded protein changes the landscape of HSC70 binding partners. by Seung W. Ryu (9143069)

“…Summary of proteins identified that increased, decreased, or were statistically indistinguishable in aggregate fraction with SOD1(A4V) expression. …”

DataSheet_5_5-Methylcytosine Related LncRNAs Reveal Immune Characteristics, Predict Prognosis and Oncology Treatment Outcome in Lower-Grade Gliomas.docx by Jiheng Zhang (11953919)

“…Consequently, we identified four lncRNAs, including LINC00265, CIRBP-AS1, GDNF-AS1, and ZBTB20-AS4, and established a novel m5C-related lncRNAs signature (m5CrLS) that was effective in predicting prognosis. …”

Degradation of aggregate-prone αA-crystallin mutant, R116C. by Ilangovan Raju (333566)

“…After 24 h transfection, cells were treated with 20 µg/ml of cycloheximide and lysed with lysis buffer at indicated time points. For each of the sample, 5 µg of total protein was loaded and western blot probed with an anti-αA-crystallin (rabbit polyclonal, Enzo Life Sciences Inc., Catalog # SPA-221). …”

The Role of <em>AtMUS81</em> in Interference-Insensitive Crossovers in A. thaliana by Luke E Berchowitz (33566)

“…To examine its role in meiosis, we employed a pollen tetrad–based visual assay. Data from genetic intervals on Chromosomes 1 and 3 show that <em>Atmus81</em> mutants have a moderate decrease in meiotic recombination. …”

Resource consumption of multi-substance users in the emergency room: A neglected patient group by Laurence Klenk (7434560)

“…</p><p>Results</p><p>The analysis includes 867 ED consultations of multi-substance users compared to 4,335 age-matched controls (5:1). Multi-substance users needed more total resources (median tax points [medical currency] (IQR): 762 (459–1226) vs. 462 (196–833), p<0.001), especially physician, radiology, and laboratory resources. …”

Table_5_v1_Preoperative Oral Carbohydrate Levels in Patients with Type 2 Diabetes Mellitus: The Clinical Guiding Significance of Free Fatty Acids.docx by Jiuhui Yang (11618329)

Unique immune and other responses of human nasal epithelial cells infected with H5N1 avian influenza virus compared to seasonal human influenza A and B viruses by Kai Sen Tan (5945789)

“…<p>Highly pathogenic avian influenza (HPAI) virus (e.g. H5N1) infects the lower airway to cause severe infections, and constitute a prime candidate for the emergence of disease X. …”

Synthesis, Structure, and Magnetic Properties of a [Mn22] Wheel-like Single-Molecule Magnet by Muralee Murugesu (1431817)

“…Variable-temperature direct current (dc) magnetic susceptibility data were collected for complex <b>1</b> in the 1.8−300 K temperature range in a 1 T applied field. The χ_M<i>T</i> value steadily decreases from 56 cm³ K mol^-1 at 300 K to 48.3 cm³ K mol^-1 at 30 K and then increases slightly to reach a maximum value of 48.6 cm³ K mol^-1 at 15 K before dropping rapidly to 40.3 cm³ K mol^-1 at 5 K. …”

Day 1–2 sBTLA concentrations and day 1 delta-SOFA. by Anna Lange (583057)

Diatom taxa change points Diatom taxa-specific results from TITAN relative to stressors (A) impervious cover (IC; %), (B) flow permanence index (FPI; %), (C) specific conductivity... by Brent J. Bellinger (21156150)

“…Taxa <i>z</i> scores (i.e., strength of stressor response) for decreasers and increasers are provided in <a href="/article/info:doi/10.1371/journal.pwat.0000340#pwat.0000340.s005" target="_blank">S5</a> and <a href="/article/info:doi/10.1371/journal.pwat.0000340#pwat.0000340.s006" target="_blank">S6 Figs</a>, respectively.…”

SIRT5 proviral activity is partially independent from the interaction with Nsp14. by Marius Walter (13775591)

“…B. Decrease in supernatant-associated viral mRNA levels in HCT-8 cells infected with HCoV-OC43 for 5 days at MOI = 0.1, and treated with SIRT5 inhibitor Sirt5-i, as shown by RT-qPCR. …”

The role of local gut response in controlling the loads of <i>Lactobacillus</i> (L) and <i>Acetobacter</i> (A) in P0 pupae and pharate adults. by Catarina Nunes (3542330)