Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone by Ina Gielisch (1348827)

“…Pathway and network analyses revealed that the respiratory chain was highly deregulated, with metabolites such as FMN, FAD, NAD⁺, and ADP, direct players of the OXPHOS system, and metabolites of the TCA cycle decreased up to 100-fold. Synthesis of functional iron–sulfur clusters, which are of central importance for the electron transfer chain, and degradation products like bilirubin were also significantly reduced. …”

Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone by Ina Gielisch (1348827)

“…Pathway and network analyses revealed that the respiratory chain was highly deregulated, with metabolites such as FMN, FAD, NAD⁺, and ADP, direct players of the OXPHOS system, and metabolites of the TCA cycle decreased up to 100-fold. Synthesis of functional iron–sulfur clusters, which are of central importance for the electron transfer chain, and degradation products like bilirubin were also significantly reduced. …”

Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone by Ina Gielisch (1348827)

“…Pathway and network analyses revealed that the respiratory chain was highly deregulated, with metabolites such as FMN, FAD, NAD⁺, and ADP, direct players of the OXPHOS system, and metabolites of the TCA cycle decreased up to 100-fold. Synthesis of functional iron–sulfur clusters, which are of central importance for the electron transfer chain, and degradation products like bilirubin were also significantly reduced. …”

Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone by Ina Gielisch (1348827)

“…Pathway and network analyses revealed that the respiratory chain was highly deregulated, with metabolites such as FMN, FAD, NAD⁺, and ADP, direct players of the OXPHOS system, and metabolites of the TCA cycle decreased up to 100-fold. Synthesis of functional iron–sulfur clusters, which are of central importance for the electron transfer chain, and degradation products like bilirubin were also significantly reduced. …”

Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone by Ina Gielisch (1348827)

“…Pathway and network analyses revealed that the respiratory chain was highly deregulated, with metabolites such as FMN, FAD, NAD⁺, and ADP, direct players of the OXPHOS system, and metabolites of the TCA cycle decreased up to 100-fold. Synthesis of functional iron–sulfur clusters, which are of central importance for the electron transfer chain, and degradation products like bilirubin were also significantly reduced. …”

<b>Postnatal development in the cold render bird mitochondria more susceptible to heat stress</b> by Maria Correia (21077207)

“…To investigate whether any postnatal developmental effects were reversible, half of the cold- and warm-acclimated birds were assigned to a common garden (20°C) 3 weeks before the measurements. …”

Supplementary Material for: Tislelizumab vs sorafenib in first-line treatment of unresectable hepatocellular carcinoma: impact on health-related quality of life in RATIONALE-301 st... by Finn R.S. (4148578)

“…At cycle 4 and 6, patients in the tislelizumab arm maintained in EQ-5D-5L visual analog scale, whereas scores decreased for the patients in the sorafenib arm. …”

Categorising trajectories and individual item changes of the North Star Ambulatory Assessment in patients with Duchenne muscular dystrophy by Francesco Muntoni (228210)

“…We utilised latent class trajectory analysis of longitudinal NSAA scores, which produced evidence for at least four clusters of boys sharing similar trajectories versus age in decreasing order of clinical severity: 25% of the boys were in cluster 1 (NSAA falling to ≤ 5 at age ~10y), 35% were in cluster 2 (NSAA ≤ 5 ~12y), 21% in were cluster 3 (NSAA≤ 5 ~14y), and 19% in cluster 4 (NSAA > 5 up to 15y). …”

Image_4_Geochemistry of Noble Gases and CO2 in Fluid Inclusions From Lithospheric Mantle Beneath Wilcza Góra (Lower Silesia, Southwest Poland).JPEG by Andrea Luca Rizzo (6038867)

“…Olivine (Ol) is classified into two groups based on its forsterite content: (1) Fo_88.9−91.5, which accounts for a fertile-to-residual mantle, and (2) Fo_85.5−88.1, which indicates large interactions with circulating (basic) melts. …”

Image_1_Geochemistry of Noble Gases and CO2 in Fluid Inclusions From Lithospheric Mantle Beneath Wilcza Góra (Lower Silesia, Southwest Poland).JPEG by Andrea Luca Rizzo (6038867)

“…Olivine (Ol) is classified into two groups based on its forsterite content: (1) Fo_88.9−91.5, which accounts for a fertile-to-residual mantle, and (2) Fo_85.5−88.1, which indicates large interactions with circulating (basic) melts. …”

Image_2_Geochemistry of Noble Gases and CO2 in Fluid Inclusions From Lithospheric Mantle Beneath Wilcza Góra (Lower Silesia, Southwest Poland).JPEG by Andrea Luca Rizzo (6038867)

“…Olivine (Ol) is classified into two groups based on its forsterite content: (1) Fo_88.9−91.5, which accounts for a fertile-to-residual mantle, and (2) Fo_85.5−88.1, which indicates large interactions with circulating (basic) melts. …”

Data_Sheet_1_Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China.docx by Yakun Zhao (5866340)

“…</p><p>Conclusions: These results suggested that high levels of air pollution had an adverse effect on childhood asthma, even in a region with high-quality healthcare. Therefore, it will be significant to decrease hospital admissions for asthma in children by controlling air pollution emission and avoiding exposure to air pollution.…”

Image_6_Geochemistry of Noble Gases and CO2 in Fluid Inclusions From Lithospheric Mantle Beneath Wilcza Góra (Lower Silesia, Southwest Poland).JPEG by Andrea Luca Rizzo (6038867)

“…Olivine (Ol) is classified into two groups based on its forsterite content: (1) Fo_88.9−91.5, which accounts for a fertile-to-residual mantle, and (2) Fo_85.5−88.1, which indicates large interactions with circulating (basic) melts. …”

Data_Sheet_1_Geochemistry of Noble Gases and CO2 in Fluid Inclusions From Lithospheric Mantle Beneath Wilcza Góra (Lower Silesia, Southwest Poland).docx by Andrea Luca Rizzo (6038867)

“…Olivine (Ol) is classified into two groups based on its forsterite content: (1) Fo_88.9−91.5, which accounts for a fertile-to-residual mantle, and (2) Fo_85.5−88.1, which indicates large interactions with circulating (basic) melts. …”

Image_3_Geochemistry of Noble Gases and CO2 in Fluid Inclusions From Lithospheric Mantle Beneath Wilcza Góra (Lower Silesia, Southwest Poland).JPEG by Andrea Luca Rizzo (6038867)

“…Olivine (Ol) is classified into two groups based on its forsterite content: (1) Fo_88.9−91.5, which accounts for a fertile-to-residual mantle, and (2) Fo_85.5−88.1, which indicates large interactions with circulating (basic) melts. …”

Image_7_Geochemistry of Noble Gases and CO2 in Fluid Inclusions From Lithospheric Mantle Beneath Wilcza Góra (Lower Silesia, Southwest Poland).JPEG by Andrea Luca Rizzo (6038867)

“…Olivine (Ol) is classified into two groups based on its forsterite content: (1) Fo_88.9−91.5, which accounts for a fertile-to-residual mantle, and (2) Fo_85.5−88.1, which indicates large interactions with circulating (basic) melts. …”

Data_Sheet_1_IL-6 Impairs Vaccine Responses in Neonatal Mice.docx by Jiyeon Yang (5947400)

“…Underscoring the importance of IL-6 in T_FH generation, we found improved antibody responses accompanied by increased T_FH cells and decreased follicular regulatory helper T (T_FR) cells, a Foxp3 expressing inhibitory CD4⁺ T cell occupying the germinal center (GC), when a tetanus toxoid conjugated pneumococcal polysaccharide type 14 vaccine was injected in adult mice together with IL-6. …”

Glibenclamide alters the subsets of T cells in both spleen and pancreatic-draining lymph nodes. by Smaragda Lamprianou (3599570)

“…<p><b>a)</b> After 3 wks of treatment (mice 6 wk of age), FACS analysis showed that the treatment with glibenclamide dose 2 (solid symbols) increased the proportion of the effector subsets of CD44^hiCD62L^- T cells, and decreased that of the naïve subset of CD44^loCD62L⁺ T cells in CD4⁺ (top panel) and CD8⁺ T cells (bottom panel), as compared to control values (open symbols). …”

Effect of forskolin on collagen mRNA expression in guinea pig sclera. by Yijin Tao (444317)

“…<p>Injection of forskolin for 1 week significantly decreased the expression of mRNAs for collagens III and V in the experimental eyes. …”

Simulations of changes in superoxide levels at low (left panels) and high (right panels) iron conditions. by Szabolcs Semsey (16767)

“…At zero time the maximal transcription rate of SodA (<i>α_A</i>) was increased 6-fold (top panels) or decreased from this induced level to the uninduced level (bottom panels). …”