A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... by Thirumal Kumar, D

“…We also performed a virtual screening analysis with 19 AKT inhibitors obtained from the Selleck Chemicals website those satisfied the Lipinski rule of 5. …”
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Image_1_The fecal carriage rate of extended-spectrum β-lactamase–producing or carbapenem-resistant Enterobacterales among Japanese infants in the community at the 4-month health ex... by Soichiro Kawata (16329168)

“…Enterobacterales producing CTX-M-9 ± TEM were broadly distributed among the positive samples (65.5%), whereas the CTX-M-1 group was exclusively detected among those from “Hospital A”. …”

DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in <i>Caenorhabditis elegans</i> by Jennifer M. A. Tullet (244402)

“…Knock down of <i>aakg-4</i> expression caused a transient decrease in activation of expression in multiple DAF-16 target genes. …”

Differential gene expression in 17<i>syn</i>⁺-, 17ΔN/H-, m2kb-S-, and 17-37-infected skin <i>in vivo</i>. by Emilia A. H. Vanni (9922652)

“…<p>Differential gene expression between any two viruses out of 17<i>syn</i>⁺ (n = 4), 17ΔN/H (n = 3), 17-37 (n = 3), and m2kb-S (n = 3) in infected skin xenografts was calculated using DESeq2 on 3SEQ data. For any gene, a positive log₂-fold change indicates an increase in the first virus over the other, whereas a negative value indicates a decrease. …”

Supplementary Material for: Effects of Low and Standard Fluoride Toothpastes on Caries and Fluorosis: Systematic Review and Meta-Analysis by Santos A.P.P. (4138099)

“…Thus, a widespread support of low F toothpastes has been observed. …”

Scale-Adjusted Metrics for Predicting the Evolution of Urban Indicators and Quantifying the Performance of Cities by Luiz G. A. Alves (441209)

“…We further employ these models to forecast future values of urban indicators and, by visualizing the predicted changes, we verify the emergence of spatial clusters characterized by regions of the Brazilian territory where we expect an increase or a decrease in the values of urban indicators.</p></div>…”

Statistical index <i>η</i> as a function of <i>I</i>_<i>CaL</i> for different values of <i>I</i>_<i>Kr</i>. by Enid Van Nieuwenhuyse (4669237)

“…<p>The calculation of <i>η</i> for a threshold of -60 mV and the last second of the burst pacing simulation. …”

DataSheet1_Effects of modified Danggui Sini Decoction as adjuvant therapy for angina pectoris in coronary heart disease: a systematic review and meta-analysis based on randomised c... by He Wang (250350)

“…The quality of included studies was assessed using the Cochrane Handbook version 5.1, and meta-analysis was executed via RevMan 5.4 software.…”

Parallel trend test. by Wei Wang (17594)

Fig 6 - by Anant Shinde (3954662)

Schoenfeld residual tests. by Adane Petros (11320648)

“…</p><p>Conclusion</p><p>Our study found that peripheral venous catheter use for vasopressor administration in circulatory shock was associated with a low extravasation rate (1.2%), with all events occurring after more than five days, indicating it might be a safe alternative to CVC for short-term use in resource-limited settings. …”

Data Sheet 1_Associations between high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and their ratio with metabolic dysfunction-associated steatotic li... by Hong Chen (108084)

“…Kaplan–Meier analysis, Cox proportional hazards models, restricted cubic splines (RCS), sensitivity analyses, and receiver operating characteristic (ROC) curves were employed to evaluate associations between NHHR, non-HDL-C, HDL-C, and new-onset MASLD and compare predictive performance across lipid parameters.</p>Results<p>A total of 36,897 participants (mean age 42.1 years; 56.5% female) were followed for a mean of 3.19 years, with 20.3% developing new-onset MASLD. …”

Data Sheet 2_Associations between high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and their ratio with metabolic dysfunction-associated steatotic li... by Hong Chen (108084)

“…Kaplan–Meier analysis, Cox proportional hazards models, restricted cubic splines (RCS), sensitivity analyses, and receiver operating characteristic (ROC) curves were employed to evaluate associations between NHHR, non-HDL-C, HDL-C, and new-onset MASLD and compare predictive performance across lipid parameters.</p>Results<p>A total of 36,897 participants (mean age 42.1 years; 56.5% female) were followed for a mean of 3.19 years, with 20.3% developing new-onset MASLD. …”

Image_1_Expressing a Target Mimic of miR156fhl-3p Enhances Rice Blast Disease Resistance Without Yield Penalty by Improving SPL14 Expression.JPEG by Ling-Li Zhang (482443)

“…MIM156-3p also enhanced the mRNA abundance of SPL14 and WRKY45 by down-regulating miR156-5p and pre-miR156. Moreover, MIM156-3p lines displayed a decreased number of second rachis branches per panicle but enlarged grains, leading to unchanged yield per plant. …”

Image_2_Expressing a Target Mimic of miR156fhl-3p Enhances Rice Blast Disease Resistance Without Yield Penalty by Improving SPL14 Expression.JPEG by Ling-Li Zhang (482443)

“…MIM156-3p also enhanced the mRNA abundance of SPL14 and WRKY45 by down-regulating miR156-5p and pre-miR156. Moreover, MIM156-3p lines displayed a decreased number of second rachis branches per panicle but enlarged grains, leading to unchanged yield per plant. …”

Image_3_Expressing a Target Mimic of miR156fhl-3p Enhances Rice Blast Disease Resistance Without Yield Penalty by Improving SPL14 Expression.JPEG by Ling-Li Zhang (482443)

“…MIM156-3p also enhanced the mRNA abundance of SPL14 and WRKY45 by down-regulating miR156-5p and pre-miR156. Moreover, MIM156-3p lines displayed a decreased number of second rachis branches per panicle but enlarged grains, leading to unchanged yield per plant. …”

Table_1_Expressing a Target Mimic of miR156fhl-3p Enhances Rice Blast Disease Resistance Without Yield Penalty by Improving SPL14 Expression.XLSX by Ling-Li Zhang (482443)

“…MIM156-3p also enhanced the mRNA abundance of SPL14 and WRKY45 by down-regulating miR156-5p and pre-miR156. Moreover, MIM156-3p lines displayed a decreased number of second rachis branches per panicle but enlarged grains, leading to unchanged yield per plant. …”

Image_4_Expressing a Target Mimic of miR156fhl-3p Enhances Rice Blast Disease Resistance Without Yield Penalty by Improving SPL14 Expression.JPEG by Ling-Li Zhang (482443)

“…MIM156-3p also enhanced the mRNA abundance of SPL14 and WRKY45 by down-regulating miR156-5p and pre-miR156. Moreover, MIM156-3p lines displayed a decreased number of second rachis branches per panicle but enlarged grains, leading to unchanged yield per plant. …”

Image_6_Expressing a Target Mimic of miR156fhl-3p Enhances Rice Blast Disease Resistance Without Yield Penalty by Improving SPL14 Expression.JPEG by Ling-Li Zhang (482443)

“…MIM156-3p also enhanced the mRNA abundance of SPL14 and WRKY45 by down-regulating miR156-5p and pre-miR156. Moreover, MIM156-3p lines displayed a decreased number of second rachis branches per panicle but enlarged grains, leading to unchanged yield per plant. …”

Carbohydrate Modified Diet & Insulin Sensitizers Reduce Body Weight & Modulate Metabolic Syndrome Measures in EMPOWIR (Enhance the Metabolic Profile of Women with Insulin Resistanc... by Harriette R. Mogul (635355)

“…</p><p>Results</p><p>Six-month fasting insulin declined significantly in the M group: 12.5 to 8.0 µU/ml, <i>p</i> = .026. Mean 6-month weight decreased significantly and comparably in D, M, and MR groups: 4.7, 5.4, and 5.5% (<i>p’s</i>.049, .002, and.032). …”