Increasing myosin light chain 3f (MLC3f) protects against a decline in contractile velocity by Jong-Hee Kim (6570014)

“…In myosin heavy chain (MHC) type IIB fibers HU induces a reduction in contraction speed (Vo) and a reduction in the relative myosin light chain 3f (MLC3f) protein content compared with myosin light chain 1f (MLC1f) protein. …”

DataSheet_1_Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis.pdf by Wenjuan Shen (3964022)

“…Results showed that the ingestion of curcumin decreased body mass index (WMD -0.267, 95% CI -0.450 to -0.084, P = 0.004, I² = 0.0%), fasting plasma glucose (WMD -3.618, 95% CI -5.165 to -2.071, P < 0.001, I² = 20.4%), insulin (WMD -1.834, 95% CI -2.701 to -0.968, P < 0.001, I² = 8.4%), homeostatic model assessment for insulin resistance (WMD -0.565, 95% CI -0.779 to -0.351, P < 0.001, I² = 0.0%), total cholesterol (WMD -15.591, 95% CI -27.908 to -3.273, P = 0.013, I² = 68.9%), C-reactive protein (WMD -0.785, 95% CI -1.553 to -0.017, P = 0.045, I² = 23.9%), and increased the quantitative insulin sensitivity check index (WMD 0.011, 95% CI 0.005 to 0.017, P = 0.001, I² = 39.6%). …”

Data Sheet 1_Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis.zip by Dongsheng Wu (2469307)

“…Meta-analysis was performed using RevMan 5.3 software.</p>Results<p>The randomized controlled trials (RCTs) included in this review examined dietary supplementation with eight polyphenols—curcumin, resveratrol, anthocyanins, quercetin, salidroside, dietary beetroot juice, pomegranate juice, and adjunctive oral AKL1 treatment—across a total of 894 participants. …”

DataSheet_3_Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis.pdf by Wenjuan Shen (3964022)

“…Results showed that the ingestion of curcumin decreased body mass index (WMD -0.267, 95% CI -0.450 to -0.084, P = 0.004, I² = 0.0%), fasting plasma glucose (WMD -3.618, 95% CI -5.165 to -2.071, P < 0.001, I² = 20.4%), insulin (WMD -1.834, 95% CI -2.701 to -0.968, P < 0.001, I² = 8.4%), homeostatic model assessment for insulin resistance (WMD -0.565, 95% CI -0.779 to -0.351, P < 0.001, I² = 0.0%), total cholesterol (WMD -15.591, 95% CI -27.908 to -3.273, P = 0.013, I² = 68.9%), C-reactive protein (WMD -0.785, 95% CI -1.553 to -0.017, P = 0.045, I² = 23.9%), and increased the quantitative insulin sensitivity check index (WMD 0.011, 95% CI 0.005 to 0.017, P = 0.001, I² = 39.6%). …”

Is Butter Back? A Systematic Review and Meta-Analysis of Butter Consumption and Risk of Cardiovascular Disease, Diabetes, and Total Mortality by Laura Pimpin (3161157)

“…These findings do not support a need for major emphasis in dietary guidelines on either increasing or decreasing butter consumption, in comparison to other better established dietary priorities; while also highlighting the need for additional investigation of health and metabolic effects of butter and dairy fat.…”

DataSheet_2_Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis.pdf by Wenjuan Shen (3964022)

“…Results showed that the ingestion of curcumin decreased body mass index (WMD -0.267, 95% CI -0.450 to -0.084, P = 0.004, I² = 0.0%), fasting plasma glucose (WMD -3.618, 95% CI -5.165 to -2.071, P < 0.001, I² = 20.4%), insulin (WMD -1.834, 95% CI -2.701 to -0.968, P < 0.001, I² = 8.4%), homeostatic model assessment for insulin resistance (WMD -0.565, 95% CI -0.779 to -0.351, P < 0.001, I² = 0.0%), total cholesterol (WMD -15.591, 95% CI -27.908 to -3.273, P = 0.013, I² = 68.9%), C-reactive protein (WMD -0.785, 95% CI -1.553 to -0.017, P = 0.045, I² = 23.9%), and increased the quantitative insulin sensitivity check index (WMD 0.011, 95% CI 0.005 to 0.017, P = 0.001, I² = 39.6%). …”

Two-parameter distributions show a more confined distribution of the Class IV parameter sets than the Class III sets. by Xiangyu Yao (3203703)

“…Case (iii): The parameter sets in case (i) that satisfy −1.5≤log₁₀<i>k</i>_dgrd≤−1. As the mean degradation rate, <i>k</i>_dgrd, decreases, fewer Class IV parameter sets are found in a more confined region.…”

Prevalence and trends of gynecological diseases (GDs) among women of childbearing age, by age group and SDI. by Xiaofeng He (2618752)

Table_1_Safety and efficacy of lecanemab for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials.DOCX by Yue Qiao (4708423)

“…It is reported that lecanemab was beneficial to stabilize or slow down the decrease in CDR-SB (WMD: −0.45; 95% CI: −0.64, −0.25; p < 0.00001), ADCOMS (WMD: −0.05; 95% CI: −0.07, −0.03; p < 0.00001), ADAS-cog (WMD: −1.11; 95% CI: −1.64, −0.57; p < 0.0001), amyloid PET SUVr (WMD: −0.15; 95% CI: −0.48, 0.19; p = 0.38), amyloid burden on PET (WMD:−35.44; 95% CI: −65.22,−5.67; p = 0.02), adverse events (subjects with any TEAE) (OR: 0.73; 95% CI: 0.25, 2.15; p = 0.57), ARIA-E (OR:8.95; 95% CI: 5.36, 14.95; p < 0.00001), and ARIA-H (OR:2.00; 95% CI: 1.53, 2.62; p < 0.00001) in early AD patients.…”

Outcomes from a cohort of patients with acute kidney injury subjected to continuous venovenous hemodiafiltration: The role of negative fluid balance by Thais Oliveira Claizoni dos Santos (3937481)

“…The main cause of AKI was sepsis (52.5%). At beginning of CVVHDF, 152 patients (83%) were using vasopressors. …”

A Role for microRNA-155 Modulation in the Anti-HIV-1 Effects of Toll-Like Receptor 3 Stimulation in Macrophages by Gokul Swaminathan (134124)

“…Polyinosine-polycytidylic acid (poly(I∶C); a synthetic analog of dsRNA) and bacterial lipopolysaccharide (LPS), the ligands for Toll-like receptors (TLR) TLR3 and TLR4, respectively, are known to decrease HIV-1 infection in monocyte-derived macrophages (MDMs), but the mechanism(s) are incompletely understood. …”

Data_Sheet_1_Experiencing COVID-19, home isolation and primary health care: A mixed-methods study.docx by Sandra Parisi (8203119)

“…Waiting times for tests (mean 4.5 days, SD 4.1; 2.7days, SD 2.6, P < 0.001) and test results (mean 2.4 days, SD 1.9; 1.8 days, SD 1.3, P < 0.001) decreased. …”

DataSheet1_Efficacy and safety of Ophiocordyceps sinensis in the treatment of Hashimoto’s thyroiditis: a systematic review and meta-analysis.zip by Maoying Wei (297986)

“…Meta-analysis showed that OS preparations combined with a low-iodine diet were more effective in reducing thyroid peroxidase antibody (TPOAb) [SMD = −3.81, 95% CI (−5.07, −2.54), p < 0.00001] and thyroglobulin antibody (TgAb) [SMD = −4.73, 95% CI (−6.86, −2.61), p < 0.00001] compared to a low-iodine diet. …”

Data_Sheet_1_Impacts of Internet-Based Interventions for Veterans With PTSD: A Systematic Review and Meta-Analysis.xlsx by Yang Zhou (65942)

“…The subgroup analysis demonstrated that scores of PTSD outcome measured by a PCL (PTSD Checklist) decreased to an average score of 0.38 (95% CI –0.60 to −0.15, p=0.001). …”

Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa by Sixin Tian (7026710)

“…Here, we engineered the native biosynthetic cyclization loop of MCoTI-II (loop 6) to generate improved FXIIa inhibitors. Decreasing the loop length led to gains in potency up to 7.7-fold, with the most potent variant having five residues in loop 6 (<i>K</i>_i = 25 nM). …”

S2 Fig - Transcriptome profiling of <i>L. infantum</i>-infected human macrophages reveals sex-specific type I interferon induction by Annika Bea (17686341)

Image_1_Cellular and Humoral Immune Responses and Breakthrough Infections After Two Doses of BNT162b Vaccine in Healthcare Workers (HW) 180 Days After the Second Vaccine Dose.TIFF by Alessandra Mangia (626370)

“…SARS-CoV-2-spike protein-specific T-cell response was determined by a commercial IFN-γ release assay.…”

Image_2_Cellular and Humoral Immune Responses and Breakthrough Infections After Two Doses of BNT162b Vaccine in Healthcare Workers (HW) 180 Days After the Second Vaccine Dose.TIFF by Alessandra Mangia (626370)

“…SARS-CoV-2-spike protein-specific T-cell response was determined by a commercial IFN-γ release assay.…”

Trypsin and TMPRSS2 cleave SARS S at the same site but process different SARS S glycoforms. by Lennart Michel Reinke (4164577)

“…<p>(A) 293 T cells were cotransfected with expression plasmids for SARS S and decreasing amounts TMPRSS2 encoding plasmid and treated with trypsin or PBS. …”

Table1_Constructing more comprehensive pollination networks: integrating diurnal and nocturnal pollen data with visitation in a subalpine wetland community.xlsx by Yue Teng (621662)

“…Given that the diurnal pollen data showed new links that were preferentially attached to highly connected nodes, the level of asymmetric specialization did not decrease; however, nestedness increased 1.3-fold, and mean pollinator connectivity from 3.1 to 5.1. …”