Telomere Lengths, Pulmonary Fibrosis and Telomerase (<em>TERT</em>) Mutations by Alberto Diaz de Leon (248766)

“…Family members within kindreds who do not inherit the <em>TERT</em> mutation have shorter telomere lengths than controls, demonstrating epigenetic inheritance of a shortened parental telomere length set-point.…”

Downregulation of <i>let-7</i> miRNAs is associated with <i>C. parvum</i>-induced exosome release from epithelial cells. by Guoku Hu (186912)

“…H69 monolayers were treated with a non-specific anti-miR control or anti-<i>let-7i</i> or <i>let-7i</i> precursor, followed by exposure to <i>C. parvum</i> infection for 24 h. …”

Activation of the UPR can override the inhibition of NF-κB by IKK inhibitors in cancer cells with elevated IKK activity. by Arvin B. Tam (124164)

“…A reduction in P-IκBα and increase in total IκBα were seen corresponding to a decrease in IKK activity. …”

Effects of autophagic regulation on cardiac function. by Rong Xiao (130656)

“…Continuous K-H buffer perfusion without medication was used as a negative control. <b>A and B.</b> The left ventricular systolic pressure (LVSP) and the maximal rate of the rise/drop of left ventricular pressure (± dp/dt max) decreased in the hearts perfused with the autophagy activator rapamycin. …”

Pre-seeded scaffolds promote more effective tissue regeneration. by Paul P. Bonvallet (708039)

“…*Represents p<0.01 for all treatment groups that are significantly different from each other within the same time point. Also, all treatment groups significantly decreased over time (p<0.001).…”

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Figure bi demonstrates the increase in Rh123 fluorescence at 1 minute, 6 minutes and 12 minutes that reflects mitochondrial membrane depolarisation in PINK1 ko cells. c, d: Single cell traces of PINK1 ko neurons demonstrating that dopamine induced decrease in ΔΨ_m occurs independently of any change in [Ca²⁺]_c in some cells (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1c</a>), whereas in other cells dopamine induced decrease in ΔΨ_m co-incides with a rise in [Ca²⁺]_c (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1d</a>). e: Incubation with D1/D5 receptor antagonist SCH23390 (20 µM) did not alter the dopamine induced calcium signal or mitochondrial depolarisation in PINK1 ko neurons. f: Dopamine induced mitochondrial depolarisation was prevented by application of the PTP inhibitor 1 µM cyclosporine A.…”

Physical activity levels determine exercise-induced changes in brain excitability - Fig 3 by Tea Lulic (3369371)

“…<p>SICI: (A) Group-averaged unconditioned MEPs (i.e. MEP_TS) (with standard errors) for both groups (LOW: N = 13; HIGH: N = 11) at both time points. …”

Cholesterol is required for expression of Shh on the cell surface. by Vandana K. Grover (215181)

“…Internal staining was measured in cells that were pretreated with a saturating level of unlabeled 5E1 antibody prior to permeabilization and staining with 5E1-Alexa 647. …”

Corneal Sensitivity and Dry Eye Symptoms in Patients with Keratoconus by Lóránt Dienes (641222)

“…Tear film dynamics was assessed by Schirmer I test and by the non-invasive tear film breakup time (NI-BUT). All eyes were examined with a rotating Scheimpflug camera to assess keratoconus severity.…”

Behavioral Logic for Operant Training and Discrimination Testing by Samar B Mehta (274037)

“…As this behavior was established, <i>N</i> was increased from 0.063 s to 1.5 s.</p> <p>(C) Stimulus training. All trials in this stage were initiated by a 1.5-s nose poke. …”

Effects of ligand stimulation and targeted therapeutics on IGF1R and IR expression and phosphorylation. by Jurriaan Brouwer-Visser (578686)

“…Measured by RT-qPCR (n = 5 independent experiments each done in triplicate) IR-A and IR-B mRNA levels in HEY-T30 are significantly decreased when compared to HEY, while similar levels are observed when comparing A2780-T15 to A2780. …”

Comparison of the short-term results of nasal and temporal 180° selective laser trabeculoplasties for open-angle glaucoma by Jayter Silva Paula (10366568)

Comparison of the short-term results of nasal and temporal 180° selective laser trabeculoplasties for open-angle glaucoma by Jayter Silva Paula (10366568)

Data_Sheet_1_Data-Driven Modeling of Global Storm Surges.PDF by M. Tadesse (8762661)

“…For extreme events, the average correlation decreases to 0.54 (0.33) and RMSE increases to 14.5 (13.1) cm for extratropical (tropical) regions. …”

DataSheet_1_Membrane estrogen receptor-α contributes to female protection against high-fat diet-induced metabolic disorders.pdf by Aurélie Fabre (288323)

“…</p>Methods<p>Male and female C451A-ERα mice, harboring a point mutation which results in the abolition of membrane localization and MISS-related effects of the receptor, and their wild-type littermates (WT-ERα) were maintained on a normal chow diet (NCD) or fed a high-fat diet (HFD). …”

Chemical LTP (cLTP) stimulation induces the exodus and re-entry of DA-actin. by Toshiyuki Mizui (513144)

“…<p>(<b>A</b>) Neurons (21 DIV) were stimulated with a buffer containing 0 µM Mg²⁺, 200 µM glycine, 20 µM bicuculline, 1 µM strychnine and 0.5 µM TTX (cLTP stimulation) for 3 min and then fixed 5 or 30 min after stimulation. …”

Data_Sheet_10_Global burden of multiple sclerosis and its attributable risk factors, 1990–2019.PDF by Saeid Safiri (3713035)

“…In 2019, females exhibited a higher global point prevalence and a greater total number of prevalent MS cases than males across all age groups. …”

Data_Sheet_2_Global burden of multiple sclerosis and its attributable risk factors, 1990–2019.PDF by Saeid Safiri (3713035)

“…In 2019, females exhibited a higher global point prevalence and a greater total number of prevalent MS cases than males across all age groups. …”

Data_Sheet_14_Global burden of multiple sclerosis and its attributable risk factors, 1990–2019.PDF by Saeid Safiri (3713035)

“…In 2019, females exhibited a higher global point prevalence and a greater total number of prevalent MS cases than males across all age groups. …”

Image_1_Global burden of multiple sclerosis and its attributable risk factors, 1990–2019.JPEG by Saeid Safiri (3713035)

“…In 2019, females exhibited a higher global point prevalence and a greater total number of prevalent MS cases than males across all age groups. …”