Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders by Katrin Linda (4245613)

“…Starting from KANSL1-deficient human induced-pluripotent stem cells, both from KdVS patients and genome-edited lines, we identified SOD1 (superoxide dismutase 1), an antioxidant enzyme, to be significantly decreased, leading to a subsequent increase in oxidative stress and autophagosome accumulation. …”

Expression of a misfolded protein changes the landscape of HSC70 binding partners. by Seung W. Ryu (9143069)

“…Summary of proteins identified that increased, decreased, or were statistically indistinguishable in aggregate fraction with SOD1(A4V) expression. …”

Degradation of aggregate-prone αA-crystallin mutant, R116C. by Ilangovan Raju (333566)

“…After 24 h transfection, cells were treated with 20 µg/ml of cycloheximide and lysed with lysis buffer at indicated time points. For each of the sample, 5 µg of total protein was loaded and western blot probed with an anti-αA-crystallin (rabbit polyclonal, Enzo Life Sciences Inc., Catalog # SPA-221). …”

HH-responding cells are lost from circumvallate papilla epithelium but remain in stroma after epithelial Gli2 deletion, and taste bud size, and SHH expression, decrease with durati... by Alexandre N. Ermilov (3365972)

Effects of As₂O₃ on A431 cell EGFR expression. by Lingbo Zhang (132359)

“…Interestingly, cell numbers decreased as the arsenic trioxide concentration increased from 0 µM to 5 µM in both fluorescent and immunostained images, indicating that As₂O₃ induced a dose-dependent inhibition on tumor cell proliferation as previously reported <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046255#pone.0046255-Kumar1" target="_blank">[31]</a>.…”

Functional characterization of <i>CsYAB5</i> in cucumber. by Shuangshuang Yan (798064)

“…<p>(A–D) RNA in situ hybridization analysis of <i>CsYAB5</i> in the cucumber shoot apex and flower buds. …”

The Role of <em>AtMUS81</em> in Interference-Insensitive Crossovers in A. thaliana by Luke E Berchowitz (33566)

“…To examine its role in meiosis, we employed a pollen tetrad–based visual assay. Data from genetic intervals on Chromosomes 1 and 3 show that <em>Atmus81</em> mutants have a moderate decrease in meiotic recombination. …”

Resource consumption of multi-substance users in the emergency room: A neglected patient group by Laurence Klenk (7434560)

“…</p><p>Results</p><p>The analysis includes 867 ED consultations of multi-substance users compared to 4,335 age-matched controls (5:1). Multi-substance users needed more total resources (median tax points [medical currency] (IQR): 762 (459–1226) vs. 462 (196–833), p<0.001), especially physician, radiology, and laboratory resources. …”

PG increased the number of necrotic cells in HepJ5 cells. by Po-Li Wei (292225)

“…<p>The percentage of viable and necrotic cells was measured by high-content analysis at specific time intervals. (A) PG exposure caused a dramatic decrease in HepJ5 cell viability after 24 h. …”

DataSheet_1_Actin Beta-Like 2 as a New Mediator of Proliferation and Migration in Epithelial Ovarian Cancer.docx by Nicole Elisabeth Topalov (11470822)

“…In vitro analyses upon siRNA knockdown of ACTBL2 displayed a significantly reduced cellular viability, proliferation and migration. siRNA knockdown of NFAT5 proved a significant molecular interplay by inducing a downregulation of ACTBL2 with a thus resulting concordant alteration in cellular functions, predominantly reflected in a decreased migratory potential of EOC cells. …”

DataSheet_1_Effects of Alcohol and Cocaine in a Mutant Mouse Model of Predisposition to Post-Traumatic Stress Disorder.pdf by Eleni Paizanis (302275)

“…The spontaneous chronic consumption of either alcohol or cocaine under a 3-week free-choice progressive paradigm of alcohol (3/6/10%) or cocaine (0.2/0.4/0.6 mg/ml), was assessed in VGV transgenic mice, having full 5-HT_2C receptor editing and displaying PTSD-like behaviors. …”

Image_1_A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages.pdf by Jiawen Zhang (586977)

“…In vitro, carvedilol decreased TLR2 expression in RAW 264.7 cells, further reducing KLK5 secretion and LL-37 expression and ultimately inhibiting rosacea-like inflammatory reactions. …”

Image_2_A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages.pdf by Jiawen Zhang (586977)

“…In vitro, carvedilol decreased TLR2 expression in RAW 264.7 cells, further reducing KLK5 secretion and LL-37 expression and ultimately inhibiting rosacea-like inflammatory reactions. …”

Dynamic Lab values under 5 background colors.xlsx by yibo zhang (13821997)

“…Furthermore, the dynamic change characteristics and adaptive mechanism of body color in different background colors was studied in a black-white background conversion model. The results showed that the greyscale color decreased from 72.33 ± 2.55 to 38.22 ± 2.33, the melanocytes changed from dendritic to mass, and the L* value of the back skin increased significantly (<em>P</em> < 0.05) after transferring the loach from a black background to a white background. …”

Synthesis, Structure, and Magnetic Properties of a [Mn22] Wheel-like Single-Molecule Magnet by Muralee Murugesu (1431817)

“…Variable-temperature direct current (dc) magnetic susceptibility data were collected for complex <b>1</b> in the 1.8−300 K temperature range in a 1 T applied field. The χ_M<i>T</i> value steadily decreases from 56 cm³ K mol^-1 at 300 K to 48.3 cm³ K mol^-1 at 30 K and then increases slightly to reach a maximum value of 48.6 cm³ K mol^-1 at 15 K before dropping rapidly to 40.3 cm³ K mol^-1 at 5 K. …”

Image5_The impacts of the “4+7” pilot policy on the volume, expenditures, and daily cost of Serotonin-Specific Reuptake Inhibitors (SSRIs) antidepressants: A quasi-experimental stu... by Xiaotong Wen (336520)

DataSheet1_Impact of the COVID-19 Pandemic on the Intensity of Health Services Use in General Practice: A Retrospective Cohort Study.pdf by Yael Rachamin (6161423)

“…</p><p>Results: During the shutdown, weekly consultation counts were lower than predicted by −17.2% (total population), −16.5% (patients with hypertension), −17.5% (diabetes), −17.6% (cardiovascular disease), −15.7% (patients aged <60 years), −20.4% (60–80 years), and −14.5% (>80 years). …”

Relationship between immune response to pneumococcal conjugate vaccines in infants and indirect protection after vaccine implementation by Ron Dagan (57723)

Cell response when mutated Ste5 are recruited to the membrane. by Frédéric Pincet (79656)

“…Ste5* (respectively Ste5**) is a scaffold protein where the docking site for Ste11 (respectively Ste7) has been disrupted. …”

Hyperbolic Tension-Velocity (T-V) relationship under KCl exposure. by Yves Lecarpentier (636443)

“…In this example, the hyperbolic T-V relationship was derived from the velocity (V) of 7 isotonic afterloaded contractions, plotted against the isotonic tension level, according to the classic A.V. …”