Table_1_Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups.DOC by Jie-Jie Shen (5600129)

“…In Streptomycestsukubaensis YN06, we found that AT4_FkbB [an AT in the fourth module of tacrolimus (FK506) PKS] transferred both allylmalonyl (allmal) and emthylmalonyl (ethmal) units to ACPs, which was supposed responsible for the production of both FK506 and its analog FK520, respectively. Mutations of five residues in AT4_FkbB (Q119A, L185I-V186D-V187T, and F203L) caused decreased efficiency of allmal transfer, but a higher ratio of ethmal transfer, supposedly due to less nucleophilic attacks between Ser599 in the active site of AT4_FkbB and the carbonyl carbon in the allmal unit, as observed from molecular dynamics simulations. …”

<i>S100a4-Cre; Ext1</i>^<i>f/f</i> mice enhanced tumor growth in subcutaneous engrafted colon and pancreatic cancer cells. by Ayumi Niwa (6256790)

Data_Sheet_1_Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA.DOCX by Yuri Furusawa (5546819)

Aberrant CpG methylation of the <i>TFAP2A</i> gene constitutes a mechanism for loss of <i>TFAP2A</i> expression in human metastatic melanoma by Andrea R Hallberg (686570)

Description of biomarkers, gene, primer sequences and NCBI accession numbers. by Conceição S. Martins (468492)

Effect of topical application of GSNO/HPMC formulation on histopathologic score of rat maxillae. by Conceição S. Martins (468492)

Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model by Genmin Lu (5029949)

“…</p><p>Materials and methods</p><p><i>In vitro</i> studies characterized the interaction of andexanet with edoxaban and its ability to reverse edoxaban-mediated anti-FXa activity. In a rabbit model of surgically induced, acute hemorrhage, animals received edoxaban vehicle+andexanet vehicle (control), edoxaban (1 mg/kg)+andexanet vehicle, edoxaban+andexanet (75 mg, 5-minute infusion, 20 minutes after edoxaban), or edoxaban vehicle+andexanet prior to injury.…”

Structural−Electronic Correlation in the First-Order Phase Transition of [FeH₂L^2-Me](ClO₄)₂ (H₂L^2-Me = Bis[((2-met... by Nicolas Bréfuel (2519947)

“…Variable-temperature magnetic susceptibility measurements show the occurrence of a steep spin crossover centered at 171.5 K with a hysteresis loop of ca. 5 K width ( =174 K and = 169 K, for increasing and decreasing temperatures, respectively). …”

Structure–Activity Relationships and Discovery of (<i>S</i>)‑5‑(<i>tert</i>-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2′,1′:2,3]imidazo[4,5‑<i>h</i>]quin... by Dimitar Gotchev (1893928)

“…Optimization of a novel series of PAPD5/7 inhibitors that decrease HBsAg levels led to the tetracyclic 2-pyridone <b>AB-161</b>, which was similarly potent to <b>AB-452</b> <i>in vitro</i> and <i>in vivo</i> but showed dramatically higher rodent liver-to-plasma ratios. …”

Performance of the model with the inhibitory V0_D pathways removed. by Yaroslav I. Molkov (542831)

“…Decreasing <i>α</i> causes two bifurcations: (i) transition from symmetric alternations of flexor activity, i.e. with a phase difference of Δ<i>φ</i> = 0.5, to alternations with a phase difference of Δ<i>φ</i> ≠0.5 at X₇ and then (ii) from alternation to synchronization of flexor activity at X₆. …”

Effect of <i>slc43a3</i> deletion on the diurnal cycle of oxygen consumption (VO₂) in male and female mice. by Aaron L. Sayler (19797446)

Rapid clearance of <i>Schistosoma mansoni</i> circulating cathodic antigen after treatment shown by urine strip tests in a Ugandan fishing community – Relevance for monitoring trea... by Anna O. Kildemoes (4588861)

“…The current study aims to investigate, whether antigen clearance as a proxy for decreasing worm numbers is reflected in decreasing CCA levels in urine shortly after praziquantel treatment. …”

DataSheet_1_Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide... by Eliel Nham (13847299)

“…When Delta PRNT was estimated using the correlation equation, protective immunity at the 6-month waning point was markedly decreased (28.3% for ChAd group, 52.5% for BNT, and 66.7% for ChAd-BNT).…”

Effect of Fe and Cd interaction on root and shoot biomass (g). by Babar Hussain (9756385)

<i>elt-2</i> silencing causes decreased intestinal integrity on Bt679 but increased intestinal integrity on Bt247, while pathogen load remains the same as in controls. by Alejandra Zárate-Potes (9415842)

Dependence of the SIPAct level on the flow rate for two multimer sizes in patient-specific AVFs. by Tatiana Yu Salikhova (13899409)

Stay duration (means ± SEM, in minutes) in quinpirole-treated and in saline-treated rats exposed first to elastic and then to symmetrical object-setting (a) and rats exposed first... by Pazit Zadicario (25211)

“…</p><p></p> For each group five times (bars) are shown: the time spent in the spaces between objects (clear bar) and the time at four objects with the longest duration (dark bars; ranked from left to right in decreasing order). * indicates a significant difference between the time spent between the objects (clear bar) and the first-ranked object in each inset (the left dark bar in each inset) as revealed in a Paired t-test comparison in each test group. …”

Do ecological characteristics drive the prevalence of <i>Panulirus argus</i> virus 1 (PaV1) in juvenile Caribbean spiny lobsters in a tropical reef lagoon? by Charlotte E. Davies (8506347)

“…<div><p>PaV1 is a pathogenic virus found only to infect Caribbean spiny lobsters <i>Panulirus argus</i>, a major fishing resource. …”

Fluctuations in airway bacterial communities associated with clinical states and disease stages in cystic fibrosis by Lisa A. Carmody (330117)

“…We sequenced the V3-V5 hypervariable region of the bacterial 16S rRNA gene in DNA derived from 631 sputum specimens collected from 111 CF patients over 10 years. …”

Haller’s organ is the key sensor for cinnamaldehyde repellency in ticks. by Ceyan Kuang (8554557)