Pathways identified by IPA connects Bacopa to memory, neuroprotection and AD. by How-Wing Leung (4385896)

“…Explanation of the numbered connections: (1) ATF4 and NRF2 functionally interact with each other [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref040" target="_blank">40</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref043" target="_blank">43</a>]. (2) ATF4 is implicated in memory [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref059" target="_blank">59</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref062" target="_blank">62</a>]. (3) NRF is implicated in memory [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref063" target="_blank">63</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref067" target="_blank">67</a>]. (4) Translation initiation factor eIF2-alpha stimulates translation of ATF4 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref068" target="_blank">68</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref071" target="_blank">71</a>]. (5) eIF2-alpha is implicated in memory formation [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref072" target="_blank">72</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref073" target="_blank">73</a>]. (6) ATF4 has been implicated in Alzheimer’s disease (AD) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref074" target="_blank">74</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref078" target="_blank">78</a>]. (7) NRF2 has also been linked to AD [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref063" target="_blank">63</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref065" target="_blank">65</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref067" target="_blank">67</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref079" target="_blank">79</a>]. (8) NRF2 plays a critical role in neuroprotection [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref080" target="_blank">80</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref083" target="_blank">83</a>]. (9) FOXO3 mediates oxidative stress-induced neuronal cell death [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref084" target="_blank">84</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref087" target="_blank">87</a>]. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Slow Proton Exchange in Aqueous Solution. Consequences of Protonation and Hydration within the Central Cavity of Preyssler Anion Derivatives, [|M(H₂O)|⊃P₅W<su... by Kee-Chan Kim (2537014)

“…The rates increased as the pH was lowered, while the rate decreased to a limit of no observable exchange at pH 7. …”

Changes in RMSF induced by ATP and Gsα binding. by Elisa Frezza (1404622)

“…AC5 and AC5+ATP for the top line and AC5 and ACT+Gsα for the bottom line) on a scale of -1.2 Å → +1.2 Å.…”

Data_Sheet_1_Transgenic Kalanchoë blossfeldiana, Containing Individual rol Genes and Open Reading Frames Under 35S Promoter, Exhibit Compact Habit, Reduced Plant Growth, and Altere... by Bruno Trevenzoli Favero (10368357)

“…The anthesis timing showed that WT opened the first flower at 68.9 ± 0.9 days and the overexpressing lines showed similar or up to 24 days delay in flowering. In general, a single or low relative gene copy insertion was correlated to higher gene expression, ca. 3 to 5-fold, in rolB and ΔORF13a lines, while in ORF14 such relation was not directly linked. …”

Bayesian estimate of the CYD14 vaccine efficacy for hospitalized dengue cases in children unde 9 years of age. by Maíra Aguiar (3597134)

The profiles of subsets of CD4⁺ T cells. by Kunihiko Kotake (11986157)

Markers of prostatic budding in cultured UGS tissues. by Melissa Gamat (802437)

“…Testosterone induced the expression of <i>Nkx3</i>.<i>1</i> (A), <i>Sox9</i> (B), <i>Wif1</i> (C), <i>Notch1</i> (H) and <i>Srd5a2</i> (J). …”

Possible cell fate under oxidative stress. by Jan Balvan (710551)

Systemic 5-FU treatment caused delayed increases in auditory brainstem response (ABR) inter-peak latencies P2-P1 and P3-P1 by Ruolan Han (35102)

“…Baseline ABR hearing tests were performed on each animal one day before initiation of treatment with 5-FU (as for Figure 4). After treatment ended, follow-up ABR tests were conducted on each animal at various points during a time course of 56 days. …”

A model of R by Ken-ichi Miyazono (29881)

Table4_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.DOCX by Long Yang (139573)

“…In a mouse model of LPS-induced early pregnancy loss, the uterine SEC5 expression level and the number of M2-Mϕs at the maternal-fetal interface were significantly reduced. …”

Table2_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.DOCX by Long Yang (139573)

“…In a mouse model of LPS-induced early pregnancy loss, the uterine SEC5 expression level and the number of M2-Mϕs at the maternal-fetal interface were significantly reduced. …”

Table3_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.DOCX by Long Yang (139573)

“…In a mouse model of LPS-induced early pregnancy loss, the uterine SEC5 expression level and the number of M2-Mϕs at the maternal-fetal interface were significantly reduced. …”

Image6_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.JPEG by Long Yang (139573)

“…In a mouse model of LPS-induced early pregnancy loss, the uterine SEC5 expression level and the number of M2-Mϕs at the maternal-fetal interface were significantly reduced. …”

Table1_SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion.DOCX by Long Yang (139573)

“…In a mouse model of LPS-induced early pregnancy loss, the uterine SEC5 expression level and the number of M2-Mϕs at the maternal-fetal interface were significantly reduced. …”