Image_2_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.TIF by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

ICD-10 version 2015. by Arnauld Kaufman (12731976)

“…Our results demonstrated a significant increase in the AAPC in Brazil’s less than 1-year-old age group and a decrease in children from 5 to 19 years old. …”

CKDMR in Brazil. by Arnauld Kaufman (12731976)

“…Our results demonstrated a significant increase in the AAPC in Brazil’s less than 1-year-old age group and a decrease in children from 5 to 19 years old. …”

Image_1_Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated Ca2 + Channels in Adult Rat Cardiomyocytes.JPEG by Raúl Sampieri (8297634)

“…Previously, we reported that pharmacological preconditioning (PPC) leads to a decrease in the amplitude of L-type calcium channel current in the heart. …”

Real-Time Cytotoxicity Assay for Rapid and Sensitive Detection of Ricin from Complex Matrices by Diana Pauly (170378)

“…Upon incubation with toxin the cell status and the cytotoxic effect were visualized using a characteristic cell index–time profile. For ricin, tested in concentrations of 0.06 ng/mL or above, a concentration-dependent decrease of cell index correlating with cytotoxicity was recorded between 3.5 h and 60 h. …”

Data_Sheet_1_Impact of Alcohol Outlet Density on Reported Cases of Child Maltreatment in Japan: Fixed Effects Analysis.docx by Yuna Koyama (7462883)

“…Also, a negative association was observed between a change in the incidence of total child maltreatment by father and a change in alcohol outlet density (coefficient = −3.03, 95% confidence interval: −5.78, −0.28).…”

DataSheet_1_Regulation of SPDEF expression by DNA methylation in advanced prostate cancer.pdf by Mousa Vatanmakanian (15171089)

“…</p>Results<p>In this report, we observed that: a) there is a gradual decrease in SPDEF expression with a concomitant increase in methylated CpG sites within the SPDEF gene during prostate cancer progression from lower to higher Gleason grade; b) Expression of DNMT’s (DNMT1, 3a and 3b) is increased during prostate cancer progression, and there is an inverse correlation between SPDEF and DNMT expression; c) SPDEF levels are decreased in RC77/T, a line of PCa cells from African American origin similar to PC3 and DU145 cells (CRPC cells), as compared to LNCaP cells , a line of androgen dependent cells,; d) the 5′ CpG island of SPDEF gene are hypermethylated in SPDEF-negative CRPC ( PC3, DU145 and RC77/T) cell lines but the same regions are hypomethylated in SPDEF-positive castrate sensitive (LNCaP) cell line ; (e) expression of SPDEF in PCa cells lacking SPDEF decreases cell migration and invasion, but has no significant effect on cell proliferation, and; (f) treatment with the demethylating agent, 5-aza-2′-deoxycytidine, or silencing of the DNMT’s by siRNA, partially restores SPDEF expression in SPDEF-negative PCa cell lines, and decreases cell migration and invasion.…”

Gene expression profiles of ECs derived from mES and miPS cells. by Erin E. Kohler (503429)

“…Data represent mean +S.E.M., n=5. Experiments were repeated at least 5 times with quadruplicates.…”

<i>tph(RNAi)</i> animals lacking eye pigment are slower to orient to light. by Bramwell G. Lambrus (240053)

“…Triangles indicate the orientation of the light gradient, with the light source on the right. All points are color-coded for time, as shown by color bar legends. …”

Growth states before drug exposure affect survival. by Akihisa Seita (10063260)

“…In these experiments, MMC exposure started at 96 h (vertical broken line). Blue points represent the result of exposure to 50 nM MMC and green points represent the result of exposure to 200 nM MMC. …”

Flow cytometry-based assay for rECD-binding. by Anna Gaertner (127899)

“…The ratio_rECD-bound was significantly (p<0.01) decreased from 1.21±0.03 for samples incubated in 5 mM CaCl₂ (1) to 1.05±0.03 for samples incubated with 2 mM EGTA (2) showing that rECD-wt has a Ca²⁺-dependent binding to HT1080 cells. …”

Effect of Glucose Concentration on Life Span and Sir2 Activity in Respiratory-Deficient Mutants by Matt Kaeberlein (12437)

“…<div><p>(A) Mean replicative life span is significantly increased in PSY316 AUT <i>cyt1</i>Δ and rho⁰ cells as the glucose concentration is decreased to either 0.5% or 0.05%, relative to life span on 2% glucose. …”

HCMV-Induced Changes in Glycolytic Metabolites by Joshua Munger (66985)

“…Average fold change in the metabolite level (relative to the mock 4-h sample) is plotted on a log₂ axis. Error bars show ± 1 SE of the mean. …”

Extended Stochastic Model (Ten Cells): Robustness Analysis of the Period and Amplitude of the Internal cAMP Oscillations with Respect to Perturbations in the Model Parameters and I... by Jongrae Kim (36310)

“…The distributions of the amplitudes show a similar tendency, i.e., the mean decreases and the standard deviation increases as the magnitude of the perturbation increases. …”

Developmental trends of children's social play from 2 to 6 years. by Stéphanie Barbu (231438)

“…<p>Interactions with adults (Adu), unoccupied behavior (Uno), solitary play (Sol), onlooker behavior (Onl) and parallel play (Par) decreased significantly over the preschool years while associative play (Aso), cooperative play (Cop) and interactions with peers (Int) increased, notably with an abrupt change at 4–5 years with the predominance of associative play, and thereafter of cooperative play at 5–6 years. …”

Table4_Circadian Pharmacological Effects of Paeoniflorin on Mice With Urticaria-like Lesions.xlsx by Li Peng (83452)

“…Moreover, PF decreased the serum levels of IgE, LTB4, and HIS, and PF administration at ZT10 produced relatively superior effectiveness. …”

Table6_Circadian Pharmacological Effects of Paeoniflorin on Mice With Urticaria-like Lesions.xlsx by Li Peng (83452)

“…Moreover, PF decreased the serum levels of IgE, LTB4, and HIS, and PF administration at ZT10 produced relatively superior effectiveness. …”

Table1_Circadian Pharmacological Effects of Paeoniflorin on Mice With Urticaria-like Lesions.xlsx by Li Peng (83452)

“…Moreover, PF decreased the serum levels of IgE, LTB4, and HIS, and PF administration at ZT10 produced relatively superior effectiveness. …”

Table2_Circadian Pharmacological Effects of Paeoniflorin on Mice With Urticaria-like Lesions.xlsx by Li Peng (83452)

“…Moreover, PF decreased the serum levels of IgE, LTB4, and HIS, and PF administration at ZT10 produced relatively superior effectiveness. …”

Table3_Circadian Pharmacological Effects of Paeoniflorin on Mice With Urticaria-like Lesions.xlsx by Li Peng (83452)

“…Moreover, PF decreased the serum levels of IgE, LTB4, and HIS, and PF administration at ZT10 produced relatively superior effectiveness. …”