GJ inhibition is the key driver of single-cell Ca²⁺ spike activity. by Dharsan K. Soundarrajan (11632145)

“…<b>(B-E)</b> <i>K</i>_<i>PLC</i> is increased left-to-right (red bar), and gap junction communication is decreased left-to-right (blue bar). An increase in <i>K</i>_<i>PLC</i> results in a decrease in frequency, while decrease in gap junction communication results in single-cell Ca²⁺ spikes (red arrows).…”

Silibinin and SIL inhibit HCVpp-mediated fusion. by Jessica Wagoner (148829)

“…After a 2 min-equilibration, lipid mixing was initiated by decreasing the pH to 5.0 with diluted HCl, and R₁₈ dequenching was recorded. …”

<i>Drosophila</i> peroxisomal gene networks. by Michael F. Wangler (544124)

“…These <i>Drosophila</i> peroxisomal genes are clustered in 5 co-regulated gene clusters that were subsequently used to identify the top 1000 genes for each cluster that has a similar expression pattern from <i>Drosophila</i> gene expression data-sets. …”

Aerofoil Design for Unmanned High-Altitude Aft-Swept Flying Wings by Ahmad Abdulkarim Alsahlan (4659976)

“…The second part contains the optimisation code using a genetic algorithm. The primary target here was to design a number of aerofoils with low pitching moment, suitable for an aft-swept flying wing configuration operating at low Reynolds number in the range of about 0.5 × 106. …”

SCS Designs 6, 7, and 8. by Matthew R. Lakin (649454)

“…We tested various lengths for the substrate binding arms of the upstream DNAzyme (denoted as 5′/3′ in the Figure). These results showed that longer substrate binding arms decrease the effect on activation rate by reducing the rate of product dissociation. …”

Data_Sheet_1_SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine.doc by Lin-nan Zhu (5681939)

“…Levels of the ubiquitin-proteasome system (UPS)-related makers ubiquitin (Ub) and UbE1, as well as the autophagy-lysosome pathway (ALP)-related markers LC3, P62 and lysosomal associated membrane protein 2A (LAMP2A), were also measured in SH-SY5Y cells transfected with lentivirus and mice injected with adenovirus. …”

Image_2_P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells.JPEG by Alwin de Jong (4012250)

“…Expression of FoxP3 by systemic CD4⁺ T cells decreased 1.8 fold in ApoE3^*LeidenxPCAF^−/− after 5 months HFD and remained significantly reduced after 5 months of HFD. …”

Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP) by Jamileh Hashemi (131207)

“…Using Nexus software analysis we combined the array-CGH data with data from gene expression profilings and identified genes that were altered in both inputs. A subset of genes identified as downregulated (<em>ALDH1A3</em>, <em>ANXA1</em>, <em>TLR4</em> and <em>RAB5A</em>) or upregulated (<em>COX6A1</em>, <em>NFIX</em>, <em>ME1</em>, <em>MAPK</em> and <em>TAP2</em>) were validated by siRNA in the tolerant or parental cells to alter sensitivity to PPP and confirmed to alter sensitivity to PPP in further cell lines.…”

Metabolomics raw data and table of extracted peak areas for BT478, BT530 and NHA cells cultured in the presence of MPA, Compound 3 (IC80) or vehicle control, for 6 hours. by Agata Monika Kieliszek (14650298)

“…The linear gradient employed was as follows: 0–2.5 min 99% A, 2.5–7.5 min decrease to 80% A, 7.5–13 min to 55% B 652 and finally 13–15 min to 99% B and held for 1 min. …”

Table_1_Regulation of miRNA expression in the prefrontal cortex by fecal microbiota transplantation in anxiety-like mice.docx by Simin Chen (9549665)

“…MiRNA analysis identified five key miRNAs affecting GAD pathogenesis, including mmu-miR-10a-5p, mmu-miR-1224-5p, mmu-miR-218-5p, mmu-miR-10b-5p, and mmu-miR-488-3p. …”

Image_1_P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells.JPEG by Alwin de Jong (4012250)

“…Expression of FoxP3 by systemic CD4⁺ T cells decreased 1.8 fold in ApoE3^*LeidenxPCAF^−/− after 5 months HFD and remained significantly reduced after 5 months of HFD. …”

The Experimental Task and Typical Single-Participant Data by R. Chris Miall (86030)

“…(B and D) show the finger trajectory viewed from behind and from the right of the subject (C and E). In all panels, TMS trials are plotted in red and non-TMS trials are in blue. …”

Data_Sheet_1_Gut community alterations associated with Clostridioides difficile colonization in hospitalized gastroenterological patients with or without inflammatory bowel disease... by Aleksander Mahnic (6107273)

“…Compared to non-IBD C. difficile-non-colonized patients, IBD and C. difficile-colonized patients shared multiple common bacterial community characteristics including decreased diversity and reduced abundance of strict anaerobic bacteria. …”

Demography of normoxic and hypoxic flies by Paul Vigne (373124)

“…</p> <p>(A) Survivorship analysis.</p> <p>Hypoxia decreased the mean life span from 33.6±0.8 days (n = 79) to 6.3±0.1 days (n = 282).…”

The STIM2-TM domain activates the cytosolic region of STIMs less efficiently than that of STIM1. by Sisi Zheng (1574473)

“…Left: average time course of whole-cell I_CRAC currents measured at –100 mV. Currents mediated by STIM1121-ΔK developed significantly more slowly than control (time to peak, 72 ± 7 s versus 147 ± 9 s, <i>n</i> = 7, ****<i>P</i> < 0.0001, <i>t</i> test), with the maximal current density also reduced (–5.5 ± 0.8 pA/pF versus –1.5 ± 0.1 pA/pF, <i>n</i> = 7, *****<i>P</i> < 0.0004, <i>t</i> test). …”

Sequential responses of channel 10 in the frontal area to constant or increasing pain intensities. by Chih-Hung Lee (188177)

“…The traces are from channel 10 in the frontal area of subject M-1. (D) Mean (n = 4 subjects) peak responses in [HbO2] in channel10 in the frontal area when pain stimulation intensity was gradually increased (**<i>p</i><0.05, vs the response in the first stimulation (0.5 N)). …”

“A Cigarette a Day Keeps the Goodies Away”: Smokers Show Automatic Approach Tendencies for Smoking—But Not for Food-Related Stimuli by Alla Machulska (5662063)

“…During the AAT, 92 smokers and 51 non-smokers viewed smoking-related vs. non-smoking-related pictures and pictures of natural rewards (i.e. highly palatable food) vs. neutral pictures. …”

Disrupted elncRNA splicing impacts <i>cis</i>-gene regulation. by Jennifer Yihong Tan (11933872)

“…(D-H) Distribution of the log10 modulus fold difference in splicing (PSI), relative to the median of samples with reference genotype, between individuals that carry alternative or reference alleles at elncRNA splice site of ENSG00000205786, of all directly affected splicing events of (D) the elncRNA and (E) all splicing events of its target protein coding genes (5 targets); as well as fold difference in expression levels (RPKM) of (F) targets, (G) non-targets and (H) the elncRNA. …”

Correlation between intraocular pressure (IOP) and axial globe length biometric parameters in the various subgroups of the ED cohort. by Thomas Boillot (656368)

“…The linear regression analysis (hatched lines) demonstrated the non-linear status of the correlations, because <i>r</i>²<0.5 in all cases (a-c). …”

DNA Repair and Cell Cycle Biomarkers of Radiation Exposure and Inflammation Stress in Human Blood by Helen Budworth (121329)

“…Radiation exposure significantly modulated the transcript expression of 12 genes of 40 tested (2.2E-06CDKN1A, FDXR, BBC3, PCNA, GADD45a, XPC, POLH and <em>DDB2</em>). …”