The <i>AtTIFY10a/b</i> knockout mutant <i>Arabidopsis</i> showed decreased alkaline tolerance at the seed germination stage. by Dan Zhu (139675)

Classification and regression tree: CYP3A5 phenotype discriminates between cases and tolerants (EM = normal metabolizers, IM and PM = decrease function, UM and UMH = increase function). by Luciana Kase Tanno (785410)

“…<p>Classification and regression tree: CYP3A5 phenotype discriminates between cases and tolerants (EM = normal metabolizers, IM and PM = decrease function, UM and UMH = increase function).…”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody–drug conjugate (ADC). …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody–drug conjugate (ADC). …”

<i>Fkbp5</i> DNA methylation decreases with age in mice. by Jonathan J. Sabbagh (626366)

Image 1_A COP1-HY5-ABI5 module regulates ABA-mediated post-germination developmental arrest.pdf by Deeksha Singh (11009626)

“…Together, our results support a model in which a double-negative feedback loop between HY5 and ABI5 contributes to ABA-mediated post-germination growth arrest.…”

Fig 5 - by Christophe Verbist (6104075)

Exploring reopening strategies for a high range in disease transmission <i>v</i>_<i>r</i> with high testing capacity. by Mackenzie Dalton (14093874)

PI3K activity is required for induction of cerebellar LTP. by Claire Jackson (362873)

Table_1_When and Why Did Human Brains Decrease in Size? A New Change-Point Analysis and Insights From Brain Evolution in Ants.XLSX by Jeremy M. DeSilva (7247009)

“…<p>Human brain size nearly quadrupled in the six million years since Homo last shared a common ancestor with chimpanzees, but human brains are thought to have decreased in volume since the end of the last Ice Age. …”

S5 Table - by Marisa R. Pinson (11659514)

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

General laboratory tests and specific coagulation test in PCR SARS-CoV-2 negative and positive patients. by B. de Laat (12475632)

Excessive LF4A kinase activity shortens cilia and decreases IFT. by Yu-Yang Jiang (7036916)

Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues by Lindsay B. Tulloch (1266861)

“…<div><p>Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising trypanocidal activity of <b>compound 1</b>, a bis-tetrahydropyran 1,4-triazole (B-THP-T) inhibitor. …”

Unclustered ephrin-A5-Fc and EphA4-Fc partially reduce astrocytic gliosis. by Yona Goldshmit (205708)

“…<p>(A–C) Immunohistochemical analysis of GFAP expression 4 days after spinal cord hemisection and following 3 days administration of Fc fusion protein indicated that, (A) compared to PBS treatment (<i>n</i> = 6), ephrin-A5-Fc (<i>n</i> = 3) and EphA4-Fc (<i>n</i> = 3) treatment decreased astrocytic gliosis. …”

Pathway-Express (PE) performs a pathway level impact analysis and orders the affected pathways in the decreasing order of their expected importance for the given condition (panel 1... by Purvesh Khatri (19219)

Rabex-5 interacts with Notch in the wing. by Theresa A. Reimels (19959368)

“…<p>(A) Control <i>FRT80B/+</i> wing (genotype <i>w</i>^<i>1118</i><i>; FRT80B/+</i>). …”