The conserved phenylalanine residue in PRMT5 is critical for inhibition by the five compounds. by Gui-Mei Kong (4353751)

“…D, The F225M mutation in PRMT5 decreased the IC₅₀ values of the compounds, as determined by quantitation and analysis of methylation assay results.…”

Lithiation of 2,4,5,7-Tetrabromo-1,8-bis(dimethylamino)naphthalene: Peculiarities of Directing Groups’ Effects and the Possibility of Polymetalation by Artyom A. Yakubenko (11602733)

“…It was demonstrated that the first exchange occurs in position 4 due to the significant decrease of a steric strain of the molecule. The second exchange takes place in either position 5 or 7 due to the even more negative charge distribution in the naphthalene core. …”

<i>In vivo</i> effects of DJ-V-159. by Min Pi (375625)

“…<p>(A) The effects of DJ-V-159 on GPRC6A-mediated regulation of insulin secretion in mouse β-cells, MIN-6. …”

Effectiveness of interventions to decrease hesitancy. by Maximilian Nicolaus Burger (12969212)

GCase substrate levels are altered in the brain and liver of homozygous <i>GBA1</i> D409V KI mice. by Nicole K. Polinski (10947787)

Dopamine turnover, but not total dopamine levels or nigral dopamine neuron numbers, are altered in aged homozygous <i>GBA1</i> D409V KI mice as compared to controls. by Nicole K. Polinski (10947787)

Relationship between the decrease in hunting licences and excess mortality, in each province: Relationship in 2020–2021 (a), in 2021–2022 (b) and between 2021–2022 licences and 202... by Jacopo Cerri (6271958)

Decreased levels of glycosylated α-DG and laminin levels distal to the glial dome in <i>POMGnT1</i>-KO and <i>Large</i>^{<i>myd/myd</i>} mice. by Shigefumi Morioka (8893511)

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease by Christine M. LaPash Daniels (796881)

“…Here we tested whether lithium treatment would decrease levels of GFAP in a mouse model of Alexander disease. …”

Trichopsistides A and B: Two Highly Oxygenated Pentacyclic Polyketides with Promising Inhibitory Effects on the NF-κB Signaling Pathway from the Fungus <i>Trichoderma koningiopsis<... by Li Feng (77923)

“…Among them, <b>1</b> represented the first example of an unprecedented 5/6/6/6/5 pentacyclic ketal-containing polyketide pyridine alkaloid, and <b>2</b> possessed a novel 6/6/6/6/5 pentacyclic ketal-containing polyketide scaffold fused with an α-pyrone. …”

Purmorphamine decreases FSK-directed cAMP production in a cilium-independent manner. by Lan Ho Wei (5688020)

Epidemiologic Trends of Incidence, Death, and Disability-Adjusted Life-Years (DALYs) Rates in five Sociodemographic Index (SDI) Regions of iNTS from 1990 to 2021. by Yunjuan He (7107446)

Absence of LFA-1 results in decreased numbers of NKT cells within the regenerating liver. by Ann-Kathrin Jörger (3559358)

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Depletion of DOM-A, but not DOM-B affects s-LN_vs maintenance and PDF accumulation. by Zhenxing Liu (399809)

“…Cell number of sLN_vs (marked as square brackets), PDF, PER and TIM levels in sLN_vs were decreased in <i>dom</i> and <i>domA</i> downregulation flies brains (Top right and bottom left panels), while only affected PER and TIM levels in <i>domB</i> downregulation flies (Bottom right panel). …”

Table_1_Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.XLSX by Masahiro Yoshikawa (379956)

Image_2_Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.TIF by Masahiro Yoshikawa (379956)

Image_3_Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.TIF by Masahiro Yoshikawa (379956)

Image_1_Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.TIF by Masahiro Yoshikawa (379956)