Cullin1/5/4A degradation is mediated by caspase-1 during <i>Eh</i>-macrophage contact. by Attinder Chadha (11414273)

Subjects:

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

Renal (urea and creatinine) (a, b) and Liver function (ALT and AST) (c, d) test in serums of different experimental groups and body weight changes (e) on day 10. by Omid Mehrpour (9385929)

Rhodium Catalysts Based on Polyphenyl-Substituted Cp Ligands for Regioselective Annulation of Aryl Hydroxamates with Terminal Alkenes by Vladimir B. Kharitonov (5550077)

“…The use of the overloaded pentaphenylcyclopentadienyl ligand Cp^Ph5 or its less bulky pentabenzyl analog Cp^Bn5 resulted in a dramatic decrease in the efficiency or regioselectivity, respectively. …”

Inhibition of Rac1 decreases lamellipodia formation and increases endothelial permeability. by Jerome W. Breslin (548352)

Bilateral common carotid artery occlusion decreased percentage of freezing behavior in a non-vision dominant cued fear conditioning test. by Xue Song Tian (589186)

Effect of anthocyanin-rich fraction, as compared with 5-ASA, on body weight and on macroscopic colonic damage in rats with TNBS-induced colitis. by Sónia R. Pereira (3854467)

CARD9 deficiency results in a striking absence of neutrophils from the infected CSF that is not caused by peripheral neutropenia or decreased neutrophil survival. by Rebecca A. Drummond (437635)

Astrocytes increase contact with vessels and expression of AQP4 following Mtb infection, which is decreased in cytosis⁺ animals. by Amanda S. Latham (12093638)

“…Representative images of the frontal cortex (A–D), cerebral nuclei (G–J), brain stem (M–P), thalamus (S–V), and hippocampus (Y–BB) 15 days post-infection are shown. …”

Sox5 is a target of miR-194. by Jun Xu (45543)

Hydrogen peroxide-induced ROS formation is decreased in IRP1- cells. by Kurtis J. Haro (119844)

Nitrate and nitrite treatment did not adversely affect multiple parameters of health but nitrate treatment significantly decreased movement following a startle. by Manuel García-Jaramillo (9930572)

JM from Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts <i>in vitro</i> by Thomas Stahnke (3775621)

Fibrosis from Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts <i>in vitro</i> by Thomas Stahnke (3775621)

New research shows a link between Arctic organochlorine pollution and decreased bone mineral density in East Greenland polar bears by David J. Tenenbaum (27256)

In vitro characterization of MAb-1D8 activity. by Nanae Nagata (3916574)

“…<p>(A) MAb-1D8-mediated inhibition of 0.5 nM [³H]PGD₂ binding to mDP2 (B and C) Effects of MAb-1D8 on cAMP-production detected by CRE-mediated luciferase activity in mDP2- and CRE-expressing CHO cells. …”

File S1 - The Muscle Oxidative Regulatory Response to Acute Exercise Is Not Impaired in Less Advanced COPD Despite a Decreased Oxidative Phenotype by Ilse G. M. Slot (529297)

Liquid–Liquid Phase Separation of Peptide/Oligonucleotide Complexes in Crowded Macromolecular Media by Qingwen Bai (5221280)

“…Our study provides a further step toward a deeper understanding of the kinetics of MLOs in crowded living cells.…”

Liquid–Liquid Phase Separation of Peptide/Oligonucleotide Complexes in Crowded Macromolecular Media by Qingwen Bai (5221280)

“…Our study provides a further step toward a deeper understanding of the kinetics of MLOs in crowded living cells.…”

Liquid–Liquid Phase Separation of Peptide/Oligonucleotide Complexes in Crowded Macromolecular Media by Qingwen Bai (5221280)

“…Our study provides a further step toward a deeper understanding of the kinetics of MLOs in crowded living cells.…”