SC-1 Inhibited RSK2 Kinase Activity <i>in vitro</i> and an RSK2 Inhibitor Increased Colony Formation. by Susan D. Mertins (380936)

“…<p>COLO 205 tumor cell line was treated with SL0101 (1.25 µM) and SC-1 (0.1 µM) for 24 hrs prior to soft agar cloning, lysate preparation, and immunoblotting. A. SC-1 inhibited RSK2 N-terminal domain <i>in vitro</i> kinase activity with an EC₅₀ of 2.5±1.8 µM (mean±SD, n = 5) but not in other like assays for Aurora kinase B, CHK1, or CHK2 kinases. …”

Stimulation of Type III Nrg1 signaling enhances response to capsaicin in WT sensory axons. by Sarah E. Canetta (46254)

“…The maximum percent change in intracellular calcium ([(F−F₀)/F₀]*100) in response to capsaicin decreased between the 4^th and 5^th capsaicin applications under control conditions (left), but increased when Type III Nrg1 signaling was stimulated by sErbB4-ECD application during that interval (right). …”

Supplementary Material for: Healthcare Costs and Utilization among Patients Hospitalized for Malignant Pleural Effusion by Shafiq M. (8553936)

“…<b><i>Results:</i></b> We analyzed 92,034 hospital discharges spanning a decade (2004–2014). Yearly hospitalizations steadily decreased from 38,865 to 23,965 during this time frame, the mean LOS decreased from 7.7 to 6.3 days, and the adjusted hospital mortality decreased from 7.9 to 4.5% (<i>p</i> = 0.00 for all trend analyses). …”

DataSheet1.pdf by Vincent Portero (518206)

“…Using computer simulations employing a multicellular in silico model, we furthermore demonstrate that the experimentally observed increase in K_V4.3 current and concurrent decrease in Na_V1.5 current may result in a loss of conduction, underlining the potential functional relevance of our findings. …”

Flow cytometry-based assay for rECD-binding. by Anna Gaertner (127899)

“…The ratio_rECD-bound was significantly (p<0.01) decreased from 1.21±0.03 for samples incubated in 5 mM CaCl₂ (1) to 1.05±0.03 for samples incubated with 2 mM EGTA (2) showing that rECD-wt has a Ca²⁺-dependent binding to HT1080 cells. …”

Effect of Glucose Concentration on Life Span and Sir2 Activity in Respiratory-Deficient Mutants by Matt Kaeberlein (12437)

“…<div><p>(A) Mean replicative life span is significantly increased in PSY316 AUT <i>cyt1</i>Δ and rho⁰ cells as the glucose concentration is decreased to either 0.5% or 0.05%, relative to life span on 2% glucose. …”

The disorganized nature of SP8⁺ interneurons in GL and the expression level of SP8⁺ interneurons. by Zhenzu Li (3108309)

“…Lgl1 conditional mice exhibited severe disorganization in OB interneurons and an almost complete loss of interneurons in the GL at P21. There was a noticeable decrease of SP8⁺ interneurons in the GL of Lgl1 mutants (f^,) compared to WT controls (f). …”

<em>Lutzomyia longipalpis</em> Saliva or Salivary Protein LJM19 Protects against <em>Leishmania braziliensis</em> and the Saliva of Its Vector, <em>Lutzomyia intermedia</em> by Natalia M. Tavares (219014)

“…These alterations were associated with a significant decrease in the expression levels of IL-10 and TGF-β. …”

Data_Sheet_1_Psychological and Brain Connectivity Changes Following Trauma-Focused CBT and EMDR Treatment in Single-Episode PTSD Patients.docx by Emiliano Santarnecchi (382232)

“…Results point to a similar, beneficial psychological impact of EMDR and TF-CBT for treatment of natural-disaster PTSD patients. …”

Table_2_Association of Metabolic Syndrome With Prevalence of Obstructive Sleep Apnea and Remission After Sleeve Gastrectomy.XLSX by Yufei Chen (206648)

“…Then we performed a retrospective study, which was registered at ClinicalTrials.gov (ref. …”

Secondary screening and ‘hit’ validation. by Ilona Tkachyova (343715)

“…Treatment with 1.2 μM of SAHA resulted in a ~ 40% decrease in NDST enzyme activity. Experiments were conducted in triplicates. …”

Table_1_Association of Metabolic Syndrome With Prevalence of Obstructive Sleep Apnea and Remission After Sleeve Gastrectomy.XLSX by Yufei Chen (206648)

“…Then we performed a retrospective study, which was registered at ClinicalTrials.gov (ref. …”

Computational Investigation of the Lewis Acidity in Three-Dimensional and Corresponding Two-Dimensional Zeolites: UTL vs IPC-1P by Ho Viet Thang (1755028)

“…The adsorption and catalytic properties of three-dimensional zeolite UTL were investigated computationally along with properties of its two-dimensional analogue IPC-1P that can be obtained from UTL by a removal of D4R units. Adsorption properties and Lewis acidity of extra-framework Li⁺ sites were investigated for both two- and three-dimensional forms of UTL using the carbon monoxide as a probe molecule. …”

The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance <i>In Vitro</i> and <i>In Vivo</i> Derived from Human Breast MCF-7/ADR Cells by Long Wu (655081)

“…Multidrug resistance reversal by 3-Bromopyruvate occurred through at least three approaches, namely, a decrease in the intracellular level of ATP and HK-II bioactivity, the inhibition of ATPase activity, and the slight decrease in P-glycoprotein expression in MCF-7/ADR cells.…”

Mixed Solid Municipal Waste-Based Biochar for Soil Fertility and Greenhouse Gas Mitigation by Bansode, Rishipal

“…Municipal solid waste management is one of the major challenges facing Qatar with more than 2.5 million tons of municipal solid waste each year, a very high waste generation rate in a country with small land mass. …”
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Low salt project by Thananda Trakarnvanich (10066099)

“…The intervention group was provided a salt diet (1.5 gm/day) for 3 months. The control group consumed their usual diet; daily food intake was recorded. …”

Dapagliflozin suppresses oxidative stress and inflammatory gene expression in cultured proximal tubular epithelial cells. by Naoto Terami (512415)

“…ROS production was not increased by mannitol (b) compared with normal glucose (a), but was increased by high glucose (c). High-glucose-induced ROS production was decreased by dapagliflozin pretreatment in a dose-dependent manner (d: 0.2 nM; e: 2.0 nM; f: 20.0 nM). …”

Effectiveness of nutritional intervention in overweight women in Primary Health Care by Nathália Luíza Ferreira (12821193)

Place avoidance parameters in SC and GST-PRW rats. by Jeffrey M. Sequeira (2580553)

Preparation of glycosylated hydrolysate by liquid fermentation with Cordyceps militaris and characterization of its functional properties by Shuang YANG (8618355)