Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function by Elie Simard (481523)

“…We demonstrated that RAGE is expressed and functional in the A7r5 VSMC model, and its activation by AGE significantly increased NF-κB activity, which is known to interfere with the contractile phenotype of VSMC. …”

Changes on the silicosis profile in underground gold mining in Minas Gerais, Brazil by Leandro Liberino Silva (5500478)

“…The prevalence among those who worked underground was 3.8% for the group up to 5 years and 44,2% for the group that worked over 20 years. …”

Table_1_Hesperidin alleviates zinc-induced nephrotoxicity via the gut-kidney axis in swine.docx by Qingwen Yang (119119)

“…Thus, the exploration of effective natural antagonists to reduce the toxicity caused by Zn has become a major scientific problem.</p>Methods<p>Here, we found that hesperidin could effectively alleviate the renal toxicity induced by Zn in pigs by using hematoxylin-eosin staining, transmission electron microscope, immunohistochemistry, fluorescence quantitative PCR, and microfloral DNA sequencing.…”

Data_Sheet_1_Deciphering Microbial Community Dynamics and Biochemical Changes During Nyons Black Olive Natural Fermentations.PDF by Marine Penland (9472886)

“…During the first 7 days, phase I, a fast decrease of filamentous fungal and bacterial populations was observed. …”

Table_1_[18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity.docx by Maria I. Menendez (11935274)

“…Beagles (n = 9) were administered three different [¹⁸F]NaF doses: 111 MBq (n = 5), 20 MBq (n = 5), and 1.9 MBq (n = 9). Imaging started ≃45 min post-injection for ≃30 min total acquisition time. …”

Presentation_1_[18F] Sodium Fluoride Dose Reduction Enabled by Digital Photon Counting PET/CT for Evaluation of Osteoblastic Activity.PPTX by Maria I. Menendez (11935274)

“…Beagles (n = 9) were administered three different [¹⁸F]NaF doses: 111 MBq (n = 5), 20 MBq (n = 5), and 1.9 MBq (n = 9). Imaging started ≃45 min post-injection for ≃30 min total acquisition time. …”

Soluble CD73 in Critically Ill Septic Patients – Data from the Prospective FINNAKI Study by Suvi T. Vaara (2504209)

“…</p><p>Conclusions</p><p>Compared to normal population, the sCD73 levels were generally low at 0h, showed a decrease to 24h, and later an increase by day 5. …”

The effective half-saturation concentration of ABC transport. by Noele Norris (10826554)

“…(For a plot showing how we calculate the effective half-saturation concentration, see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009023#pcbi.1009023.s010" target="_blank">S7 Fig</a>).…”

Evolution of hnRNPA1 IDR. by Simon M. Lichtinger (11326846)

“…S1-b). <b>(C)</b> Amino-acid composition before and after using a genetic algorithm to increase the phase diagram width for hnRNPA1, revealing the appearance of hydrophobic amino acids, while no bias against charged or polar amino acids is observed. …”

Nbs1, Xrcc4, and Brca1 play distinct roles during individual repair events. by Nicole Bennardo (93380)

“…(E) Xrcc4-deficient cells show a decrease in S+DEJ. Shown are amplification products using the same primers and annotation as shown in C, from sorted GFP+ cells derived from I-SceI transfection of EJ5-GFP-containing WT cells, <i>Xrcc4−/−</i> cells, and <i>Xrcc4−/−</i> cells transiently complemented with Xrcc4 as in D. …”

<i>Vg</i> expression regulates Lp-mediated accumulation of lipids via TOR signaling. by Iryna Stryapunina (17867390)

“…(B) Fold change in protein levels, measured by Bradford assay of the fat body are increased in ds<i>Vg</i> females; each dot is representative of three fat bodies; N = number of samples of three tissues, pooled from three biological replicates (REML variance component analysis by timepoint: **** = p < 0.0001). (C) Western blot quantification from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011145#pgen.1011145.g003" target="_blank">Fig 3D</a> showing a decrease in phospho-S6K levels in the fat body upon rapamycin treatment; samples of five tissues, three biological replicates (ANOVA). …”

Fis binding site modifications, Langevin dynamics simulations of DNA breathing, and EMSA experiments, the first set. by Kristy Nowak-Lovato (101951)

“…FIS1 and FIS1S oligonucleotides were constant at 100 nM, and Fis protein ranged from 0 to 1.5 µM. (C) Langevin dynamics simulations demonstrating enhanced FIS2m2 local DNA breathing dynamics (compare to FIS2 in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002881#pcbi-1002881-g002" target="_blank">Figure 2</a>). …”

Urban morpho-material parameters in cities and their correlation with summer air temperatures by Noelia Liliana Alchapar (5863067)

“…The increase in vegetation could decrease the average temperature in Mendoza by up to 2.0 ºC, while in Campinas by up to 5.0 ºC. …”

Table_1_Impulsive choice in two different rat models of ADHD—Spontaneously hypertensive and Lphn3 knockout rats.DOCX by Monica S. Carbajal (14506454)

Table1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.docx by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Image2_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Image3_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Image1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Gamma radiation treatment applied to microbial decontamination of products derived from eggs collected from the retail market in São Paulo by S. Aquino (4770153)

“…The bacterial count was performed by the most probable number (MPN) and the fungal counts by serial dilution after plating surface. It was observed a decrease in the humidity and water activity (Aw) values of irradiated whole egg powder and white egg powder samples (p<0.05), but there was no significant change in the pH of the same samples irradiated with 5 and 10 kGy (p>0.05). …”

Table_1_Bacteraemia, Malaria, and Case Fatality Among Children Hospitalized With Fever in Dar es Salaam, Tanzania.docx by Sabrina J. Moyo (9358742)

“…</p>Methods<p>From March 2017 to July 2018, we enrolled 2,226 children aged 0–5 years hospitalized due to fever in four major public hospitals of Dar es Salaam, namely, Amana, Temeke, and Mwananyamala Regional Hospitals and Muhimbili National Hospital. …”