Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

S5 Table - by Yong-Rae Kim (19797278)

“…They (i) took a rest while viewing a gray screen for one minute; (ii) viewed a randomly displayed image of one of the three ECDs’ images for one minute; (iii) filled out questionnaires (using the semantic differential method and a profile of mood states) for five minutes; and (iv) took a rest to wash out residual sensitivity for five minutes. …”

A decrease in the amount of HBV nucleocapsids occurs when there is overexpression of singly-spliced2.2 kb RNA <i>in vivo</i>. by Yi-Ling Wang (704612)

Ni causes a decrease in membrane sterols in A549 lung epithelial cells. by Amber R. Matha (19681603)

Pairwise correlations of excitatory neurons in APP/PS1 mice are decreased in dCA1, but increased in vCA1. by Udaysankar Chockanathan (18510288)

Leptin Decreases FoxO3a Activity and Increases PGC-1α Protein in Gastrocnemius Muscle. by Neira Sáinz (260167)

RcbA and RcbB co-operatively decrease motility independent of CaCl₂ concentration. by Shobnom Mustaree (21728815)

TUDCA decreases ER stress in HOX neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…(<b>C</b>) In IHC stain, P-IRE1α levels are decreased (40.8±3.5 A.U. …”

B-factor values of Ca_V3.3 M1425 substitutions. by Yousra El Ghaleb (22075892)

Subjects:

Deletion of <i>sagA</i> alone results in a decrease in nasopharyngeal infection. by Blake A. Shannon (14197601)

Knockdown of 1A6/DRIM results in a decrease in 47S rRNA. by Qunhui Peng (358982)

RhoA-induced suppression of the HSR decreases cell stress resistance and induces cell death via apoptosis. by Roelien A. M. Meijering (217816)

Decrease in CLPs, NKPS and Block in NKP progression. by John Richards (53768)

Lack of SPI-14 decreased <i>S</i>. Typhimurium virulence in mice by affecting intestinal invasion. by Lingyan Jiang (4063771)

Decreased epithelial PGR expression in <i>Arid1a</i>^<i>d/d</i> mice. by Tae Hoon Kim (128536)

Decreased expression of xenoantigen Neu5Gc in hiPSCs adapted under defined culture conditions. by Yohei Hayashi (236734)

On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells by Aleksey V. Zholobenko (4491667)

Sirt5 KO induces increased lysine succinylation and decreased ATP synthase activity in mouse heart mitochondria. by Mengli Zhang (6331172)