Data_Sheet_1.pdf by Xinyu Wang (341591)

“…The initial PNP increased from 50 to 130 mg L^-1 and the k_PNP decreased from 0.093 ± 0.008 to 0.027 ± 0.001 h^-1. …”

Image1_Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity.tiff by Si Huang (5006288)

“…In vitro, TIZ dose-dependently inhibited the proliferation of U87, U118, and A172 human glioblastoma (GBM) cells at 48 h with IC₅₀ values of 1.10, 2.31, and 0.73 µM, respectively. …”

Iron oxide nanoparticles alleviate salt-alkaline stress and improve growth by modulating antioxidant defense system in cherry tomato by Raheel Shahzad (9700705)

“…SAS conditions decreased biomass and nutrients in untreated plants, a trend reversed by FeONPs. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Chemotherapy Drug Induced Discoordination of Mitochondrial Life Cycle Detected by Cardiolipin Fluctuation by Yu-Jen Chao (665872)

“…These chemotherapy drugs showed significant toxicity and growth inhibition to the cancer cells measured by MTT assay. After treated with a 50% inhibitory dosage for 48 hours, these cancer cells showed significant accumulation of cardiolipin (CL), which was a reverse trend of the nutritional deficiency induced arrest at G1 phase. …”

Data_Sheet_1_Public Database-Driven Insights Into Aging Stress-Associated Defective Gut Barrier With Low SARS-CoV-2 Receptors.PDF by Yuseok Moon (4877827)

“…<p>The novel coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global pandemic, and resulted in high case-fatality rate in the elderly. …”

Particle Imaging Velocimetry Evaluation of Intracranial Stents in Sidewall Aneurysm: Hemodynamic Transition Related to the Stent Design by Pierre Bouillot (668911)

“…<div><p>We investigated the flow modifications induced by a large panel of commercial-off-the-shelf (COTS) intracranial stents in an idealized sidewall intracranial aneurysm (IA). …”

Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by <i>Bacopa monnieri</i> Extract (CDRI-08) in Streptozoto... by Surya P. Pandey (768295)

“…Here, we demonstrate that DM2 mice treated orally with lower dose of CDRI-08 (50- or 100 mg/kg BW) is able to significantly enhance spatial memory in STZ-DM2 mice and this is correlated with a significant decline in oxidative stress and up regulation of the AMPA receptor GluR2 subunit gene expression in the hippocampus. …”

Table3_Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity.docx by Si Huang (5006288)

“…In vitro, TIZ dose-dependently inhibited the proliferation of U87, U118, and A172 human glioblastoma (GBM) cells at 48 h with IC₅₀ values of 1.10, 2.31, and 0.73 µM, respectively. …”

Table4_Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity.docx by Si Huang (5006288)

“…In vitro, TIZ dose-dependently inhibited the proliferation of U87, U118, and A172 human glioblastoma (GBM) cells at 48 h with IC₅₀ values of 1.10, 2.31, and 0.73 µM, respectively. …”

GIT1 and LAR depletion inhibit cell spreading and prevent enhanced spreading by liprin-α1 overexpression. by Claudia Asperti (217787)

“…<p>(A) Specific and control (Luc = luciferase) siRNA duplexes were used to downregulate the expression of endogenous GIT1, GIT2, liprin-α1 and LAR in COS7 cells. …”

Presentation1_Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity.pdf by Si Huang (5006288)

“…In vitro, TIZ dose-dependently inhibited the proliferation of U87, U118, and A172 human glioblastoma (GBM) cells at 48 h with IC₅₀ values of 1.10, 2.31, and 0.73 µM, respectively. …”

Data for the phycosphere pH of unicellular nano- and micro- phytoplankton cells and consequences for iron speciation by Fengjie Liu (12287945)

“…Furthermore, previous modelling work suggests that phycosphere pH of small cells is close to bulk seawater, and this has not been experimentally verified. Here we observe under 140 μmol photons·m-2·s-1 the phycosphere pH of <em>Chlamydomonas concordia</em> (5 µm),  <em>Emiliania huxleyi </em>(5 µm), <em>Coscinodiscus radiatus </em>(50 µm) and <em>C. wailesii </em>(100 µm) are 0.11, 0.20, 0.41 and 0.15 higher than bulk seawater (pH 8.00), respectively. …”

Reappraisal of the Trophic Ecology of One of the World’s Most Threatened Spheniscids, the African Penguin by Maëlle Connan (680842)

“…The world population of the endangered African penguin <i>Spheniscus demersus</i> has decreased from more than 1.5 million individuals in the early 1900s to c.a. 23 000 pairs in 2013. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Table1_Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity.docx by Si Huang (5006288)

“…In vitro, TIZ dose-dependently inhibited the proliferation of U87, U118, and A172 human glioblastoma (GBM) cells at 48 h with IC₅₀ values of 1.10, 2.31, and 0.73 µM, respectively. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Data Sheet 2_Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth.xlsx by Li-Yan Zhang (5091608)

“…</p>Results<p>This study demonstrated that menthone, the primary component of Mentha haplocalyx EO, exhibited notable antifungal activity against Fusarium proliferatum (EC50 = 6.099 mmol/L). The treatment significantly inhibited hyphal growth, reduced spore germination rates from 31.49 to 4.95%, decreased spore viability from 46.88 to 20.91%, and reduced spore production by a factor of 17.92 compared with the control group while simultaneously enhancing cell membrane permeability. …”

Increased Polyamine Intake Inhibits Age-Associated Alteration in Global DNA Methylation and 1,2-Dimethylhydrazine-Induced Tumorigenesis by Kuniyasu Soda (283701)

“…In addition, increased polyamine intake was associated with a decreased incidence of colon tumors in BALB/c mice after 1,2-demethylhydrazine administration; 12 mice (60%) in the low polyamine group developed tumors, compared with only 5 mice (25%) in the high polyamine group (Fisher's exact probability = 0.027, <i>p</i> = 0.025). …”

Drug Absorption Efficiency in <em>Caenorhbditis elegans</em> Delivered by Different Methods by Shan-Qing Zheng (382120)

“…<div><p>Background</p><p><i>Caenorhbditis elegans</i> has being vigorously used as a model organism in many research fields and often accompanied by administrating with various drugs. …”