Directed Evolution of Human Heavy Chain Variable Domain (V_H) Using <i>In Vivo</i> Protein Fitness Filter by Dong-Sik Kim (113849)

“…With further screening of combinatorial framework mutation library of MG2x1, we found a consistent bias toward substitution with tryptophan at the position of 50 and 58 in V_H. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

A decreased yield of RNP1, RNP2 and RNP5 formation in the presence of protein aGAR1 is counteracted by RNA-S by Bruno Charpentier (9519)

Whole sample storing experiment: Mean FECs of day 0, day 1 and day 2 for hookworm, <i>A</i>. <i>lumbricoides</i> and <i>T</i>. <i>trichiura</i>. by Felix Bosch (10024550)

Inhibition of ILK Decreases Bipolar and Multipolar Cytokinesis while Increasing Survival of Multinucleated Cells. by William K. A. Sikkema (574881)

Modeled structures of C1-RhoGAP domain of WT PARG1, I845V and T622M mutants. by Zen Kouchi (14898435)

Total BAL cell numbers and cell differential counts. by Ana Fernandez-Bustamante (766266)

Definitions of social influence metrics (i.e., betweenness centrality or age category) network level indices (weighted (W) diameter, global efficiency and modularity, as well as un... by Maggie Wiśniewska (11965538)

Measurements of HO-1 and dephosphorylated p38-MAPK concentrations in alveolar macrophages. by Ana Fernandez-Bustamante (766266)

Lung injury features. by Ana Fernandez-Bustamante (766266)

Quantification of CD163+ BAL cells by flow-cytometry. by Ana Fernandez-Bustamante (766266)

S2 File - by Yosuke Kameno (342665)

“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”

S1 File - by Yosuke Kameno (342665)

“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”

The Minimal Data Set contains data used in this study. by Ana Fernandez-Bustamante (766266)

Lytic <i>CBP1</i> alleles cause a decrease in phospho-Akt levels in infected macrophages. by Bevin C. English (4474726)

Characteristics of EF1-driven single copy NR1I2, NR4A1, or RORA stably-transfected cells. by Yoshinori Hasegawa (308240)

Heteroplasmy evolution of cybrid clone V_50. by Anton K. Raap (109844)

“…<p>(A) Average cellular mutation load decreases with increasing passage number of clone V_50. …”

Loneliness at 50+: The role of demographic and socioeconomic factors. by Sophie Guthmuller (9955408)

“…<p>Note: The figure displays odds ratios of individual socioeconomic and demographic variables at age 50+ for three different specifications. Specification (3) includes D, a set of individual socioeconomic and demographic variables at age 50+; P, a vector of the five scores of personality traits (extraversion, agreeableness, conscientiousness, neuroticism, openness); C, a vector of childhood circumstances (wealth; health; quality of the relationship with mother, father, and friends; importance of religion), and I, country-specific fixed effects. …”

Effects of TGF-β1 on the expression of fibrosis indicators in HBdSMCs and the effects of MEL on the expression of fibrosis indicators in HBdSMCs induced by TGF-β1. by Yang Zhang (30734)