Neural activity changes during learning. by Alice Geminiani (6036272)

“…<i>Downbound-preferring MLIs</i>: the SDF progressively increases in the ISI across blocks due to the prevalence of <i>pf</i>-MLI LTP triggered by the US-related IO signal, with a peak before US onset. <i>Upbound-preferring MLIs</i>: the SDF progressively decreases in the ISI across blocks due to the prevalence of <i>pf</i>-MLI LTD triggered by <i>pf</i> spikes uncorrelated with IO activity. …”

Silencing HK2 inhibits glioma cell invasion, migration, and proliferation <i>in vitro</i> and tumorigenesis <i>in vivo</i>. by Hui Liu (33624)

“…Tumor volume was calculated every two days after injection, demonstrating a significant (p = 0.011) decrease in the tumor volume in HK2 silenced stable U87 cells. …”

Data_Sheet_2_SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.PDF by Tatiana E. Deniskova (5527175)

“…In addition, we addressed genetic relationships between local and global goat populations obtained from the AdaptMap project. Russian goats showed a high level of genetic diversity. Although a decrease in historical effective population sizes was revealed, the recent effective population sizes estimated for three generations ago were larger than 100 in all studied populations. …”

Global proteomic changes upon perturbation of Hsp90. by Teresa R. O’Meara (720286)

“…Shading indicates per-gene scaled log-fold change compared with the untreated sample, with blue indicating a decrease and red indicating an increase. …”

IL6/STAT3 modulates estrogen-induced GREB1 transcriptional activity in breast cancer cells. by Mingli Liu (304361)

“…To determine the best efficient concentration for IL-6, hormone-starved MCF-7 cells were treated with various concentrations of IL-6 (0∼100 ng/ml) for 24 h. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046410#pone-0046410-g005" target="_blank">Figure 5E</a> shows that the maximum reduction of E2-mediated GREB1 activity is seen at 10 ng/ml, the inhibitory effects are decreased regardless of whether the doses are further increased or decreased throughout the experiment. …”

Geographic Analysis of Urologist Density and Prostate Cancer Mortality in the United States by Nengliang Yao (760915)

“…</p><p>Findings</p><p>The ordinary least squares (OLS) regression found that, on average, increasing urologist density by 1 urologist per 100,000 people resulted in an expected decrease in prostate cancer mortality of -0.499 deaths per 100,000 men (95% CI -0.709 to -0.289, p-value < 0.001), or a 1.5% decrease. …”

Viral ORF57 inhibits eIF2α phosphorylation through down-regulation of PKR pathway. by Nishi R. Sharma (4543936)

“…The relative levels of p-eIF2α (Ser 51), phospho-PKR (Thr 451), total eIF2α, and total PKR in each sample were determined by Western blot with the corresponding antibodies and are plotted in bar graphs (C), with the expression level in the sample without ORF57 being set to 100% after normalized to GAPDH which served as a loading control. …”

E1 homozygous mutant flies exhibit dramatic motor impairment and reduced lifespan. by Hsiu-Yu Liu (286342)

“…The total number of flies tested for each gender and time point is indicated above each data point. Standard Deviation for each data point based on five replicate trials for each genotype is indicated by error bars for A–B. …”

<i>DDI1/2</i>-deficient effects on the rapamycin-responsive signaling to Nrf1 and proteasome. by Keli Liu (5937368)

“…<p>(A) <i>WT</i> and <i>DDI1</i>^{<i>–∕–</i>}(<i>DDI2</i>^<i>insC</i>) cell lines were transfected with an expression construct for Nrf1-V5 (+) or empty pcDNA3 vector (–) and then examined by Western blotting with V5 antibody (<i>a1</i>, <i>a3</i>); ß-actin acts as a loading control. …”

FoxP is required for dendritic growth and negatively regulates branching of type IV da neurons. by Anna Castells-Nobau (478493)

“…(L) Cumulative branch length and (M) number of endings are decreased. Controls (n = 5), <i>UAS-FoxP</i>-<i>I2</i> (n = 5). …”

Fig 6 - by Laure Bridoux (481118)

“…Correlation plot of differential MEIS binding and differential acetylation (enhancer activity) at intergenic regions (PBA versus BA2). Each point corresponds to a region with MEIS log₂ fold change >1 (FC>2); the corresponding H3K27ac value is plotted. …”

Unrestrained Rac 1 activation in pRb-expressing osteoblasts mimics pRb loss by perturbing cell adhesion. by Bernadette Sosa-García (237746)

“…Bar in (<b>A</b>)  =  20 µm. Each point in (<b>B</b>) represents the mean of 3 independent experiments ± SEM. …”

Silencing of <i>MYCN</i> selectively alters genomic DNA binding of its cofactors. by Zhihui Liu (95891)

“…(<b>B</b>) Metagene plots show that the knockdown of <i>MYCN</i> results in a decrease of average MYCN and WDR5 ChIP-seq signal at the MYCN peak center of the MYCN and WDR5 overlapped binding sites. …”

Concentration-dependence of the transcriptome response to IL-3. by Donald MacGlashan Jr. (736839)

“…Panel B: Fold changes in three groups of transcripts. Two groups were derived from SIL3-51T, those that increased with IL-3 (●, n = 34) and those that decreased with IL-3 (■, n = 17). …”

Ribosomal S6 phosphorylation in whole brain homogenate. by Dominique F. Leitner (12568901)

“…<b>C)</b> Percentage of phospho-S6 (Ser235/236) relative to total S6 indicates an average 1.19-fold decrease when comparing all Active participants to controls (p = 0.67). …”

Y-box-binding protein 1 supports the early and late steps of HIV replication by Caroline Weydert (1316550)

“…Dissection of the replication defects revealed that knockdown of YB-1 is associated with a 2- to 5-fold decrease in virion production due to interference with the viral RNA metabolism. …”

Impact of Protein Stability, Cellular Localization, and Abundance on Proteomic Detection of Tumor-Derived Proteins in Plasma by Qiaojun Fang (211668)

“…Quantitative comparison of large versus small tumors revealed that the abundance of proteins in plasma as measured by spectral count was associated with the tumor size, but the relationship was not one-to-one; a 3-fold decrease in tumor size resulted in a 16-fold decrease in protein abundance in plasma. …”

Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes <i>In Vivo</i> by Sebastian Frese (767071)

“…Comparing muscle biopsies from post- with the pre-competitive seasons a significant 2.25-fold increase of myonuclei/mm fiber, a 2.38-fold decrease of fiber area/nucleus and a 3.1-fold decrease of satellite cells (SCs) occurred. …”

miR-143 binding to the 3′ UTR of PTGS2 mRNA. by Sun Young Kim (91779)

“…In AECs, there is a 58.5% of decrease in luciferase activity following transfection with miR-143 mimic but transfection of miR-143 hairpin inhibitor does not alter luciferase activity. …”

Improving the Yield of Xenocoumacin 1 Enabled by In Situ Product Removal by Yijie Dong (5743814)

“…Relative to the routine fermentation process, the yield of Xcn1 was improved from 42.5 to 73.8 μg/mL (1.7-fold) and 12.9 to 60.3 μg/mL (4.7-fold) in three and ten days, respectively. …”