Clinical Response and Remission Results During the 12-Week Induction Period. by Satish Keshav (65388)

“…a<p>Clinical response is defined as a decrease in CDAI score from baseline ≥70.…”

Effect of supression of adiponectin receptor gene expression on androstenedione production by bovine theca cells. by Fabio V. Comim (486376)

“…After 24-h treatment with adiponectin (3 μg/mL), a relative decrease in androstenedione secretion was observed in the control group (adiponectin alone) and the scrambled RNA group, whereas an increase over 100% (dotted line) was detected in all siRNA groups. …”

Genus and phylum composition of the feline faecal microbiome. by Oliver Deusch (497048)

“…The central circular plot illustrates the community structure at the phylum level (five most abundant phyla shown) allowing for quick inference of phylum level composition at a given age as well as temporal distribution of a phylum. …”

TRPS1 redistributes ER binding to modulate ER target gene transcription. by Thomas G. Scott (4092892)

“…B: Violin and box and whisker plots for ER binding intensity fold change upon TRPS1 depletion at ER ChIP-seq peaks within 100kb of the TSS of each gene, grouped by gene class defined by change in expression upon TRPS1 depletion. …”

Effects of miR-143 on PTGS2 expression in AECs and AMCs. by Sun Young Kim (91779)

“…In AECs, PTGS2 protein expression was 1.5-fold decreased in transfection with miR-143 mimic (p = 0.014), but no changes in transfection with miR-143 inhibitor. …”

Fas2 interacting partner IgCAMs Fipi and Elff are required for imaginal disc development. by Luis Garcia-Alonso (152388)

“…While the fas2 RNAi produces a strong decrease in MAPK activation with respect to the control siblings (see also [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309891#pone.0309891.ref008" target="_blank">8</a>]), the combined expression of fipi and elff RNAis produces a significant increase.…”

Supplementary Material for: High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy by Li J. (2831522)

“…Bioinformatic analysis revealed that circ-EFCAB2 binds to miR-485-5p to increase the expression level of the ion channel CLCN6, while circ-DROSHA interacts with miR-1252-5p to decrease the expression level of ATP1A2. …”

DataSheet_1_Glutaredoxin 2 Reduces Asthma-Like Acute Airway Inflammation in Mice.pdf by Eva-Maria Hanschmann (740672)

“…The Grx2 Cys-X-X-Ser mutant that facilitates de-/glutathionylation, but does not catalyze dithiol/disulfide exchange lost the ability to protect from airway hyper reactivity and to decrease NO release by macrophages, however, it reduced the number of infiltrating immune cells and IL-5 release. …”

Serology for Trachoma Surveillance after Cessation of Mass Drug Administration by Diana L. Martin (300642)

“…Among 1–9 year olds, TF prevalence was 6.5%, whereas only 3.5% were seropositive. Force of infection modelling indicated a 10-fold decrease in seroconversion rate at a time corresponding to MDA commencement. …”

AmB-resistant strains critically depend on high levels of Hsp90 function for survival. by Benjamin Matteson Vincent (477570)

“…<p>(A) Mild inhibition of Hsp90 not only reverses AmB resistance but selectively kills AmB-resistant isolates. Spot assays (5-fold serial dilutions) of wild-type (SC5314), fluconazole-resistant (Isolate #2, <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001692#pbio.1001692-White2" target="_blank">[61]</a>), and AmB-resistant (ATCC 200955) <i>C. albicans</i> on RPMI media containing antifungals and/or Hsp90 inhibitors at the indicated concentrations. …”

Portrait of Ependymoma Recurrence in Children: Biomarkers of Tumor Progression Identified by Dual-Color Microarray-Based Gene Expression Analysis by Matthieu Peyre (241074)

“…Conversely, ASPM expression was more frequently positive at relapse (87.5% vs 37.5%, p = 0.03). Loss or deletion of the MT genes cluster was never observed at relapse. …”

Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study by Antoine Rachas (197007)

“…Their mortality rate between the ages of 14 and 21 years was 20.9/10,000 person-years (13.7–32.1) <i>versus</i> 1.9 (1.5–2.5) for adolescents without a LTD. Mortality was higher in males than females in youths without a LTD, but not in those with a LTD. …”

RAD21 is necessary for ERα binding within the <i>MYC</i> locus but not an exogenous ERE. A) RAD21 silencing abrogates ERα binding upstream of <i>MYC</i>. by Miranda V. McEwan (121381)

“…MCF7 cells were transfected for 48 hours with Control, RAD21 or ESR1 siRNA and either a negative control (NEG) plasmid, a positive control plasmid (POS) or a plasmid encoding the firefly luciferase reporter gene under the control of 5 EREs. Cells were treated with vehicle (V) or estradiol (E) for 24 hours before luciferase activity was measured. …”

A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling by Susama Chokesuwattanaskul (5813888)

“…Cell number and number of scans (NS) were optimised as >3.6 million cells and 512 NS. 327 spectral bins were defined in the neutrophil spectra, of which 287 (87.7%) were assigned to 110 metabolites that included: amino acids, peptides and analogues; carbohydrates, carbonyls and alcohols; nucleotides, nucleosides and analogues; lipids and lipid-like molecules; benzenoids; and other organic compounds. 43 metabolites changed at least 1.5 fold (increase or decrease) after the addition of PMA for 5 or 15 min. …”

2′-<em>O</em> Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo by Kristy J. Szretter (165885)

“…In comparison, WNV-E218A was virulent after intracranial infection as judged by increased infection in different regions of the central nervous system (CNS) and a greater than 16,000-fold decrease in LD₅₀ values in <em>Ifit1</em>^−/− compared to wild type mice. …”

Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools by Jun Ding (80820)

“…Both homoplasmies and heteroplasmies show 5-fold higher transition/transversion ratios than variants in nuclear DNA. …”

Table1_In utero arsenic exposure and early childhood motor development in the New Hampshire Birth Cohort Study.docx by Erin E. Butler (15428729)

“…In models adjusted for potential confounders, each doubling of urine tAs decreased overall motor proficiency by –3.3 points (95% CI: –6.1, –0.4) for tAs concentrations greater than the change point of 9.5 µg/L and decreased fine motor integration by –4.3 points (95% CI: –8.0, –0.6) for tAs concentrations greater than the change point of 17.0 µg/L.…”

Image1_In utero arsenic exposure and early childhood motor development in the New Hampshire Birth Cohort Study.tiff by Erin E. Butler (15428729)

“…In models adjusted for potential confounders, each doubling of urine tAs decreased overall motor proficiency by –3.3 points (95% CI: –6.1, –0.4) for tAs concentrations greater than the change point of 9.5 µg/L and decreased fine motor integration by –4.3 points (95% CI: –8.0, –0.6) for tAs concentrations greater than the change point of 17.0 µg/L.…”

K_eq and Φ of the α subunit. by Pallavi A. Bafna (271514)

“…Φ-values of 55 different residues plotted as a function of sequence position (≥2 mutants and >5-fold range in K_eq). Subunit domains are shown along the x-axis. …”

Image_1_Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis.JPEG by Gerjan J. Dekkema (7375049)

“…Overexpression of miR-142-3p significantly decreased cAMP levels (p = 0.02) and tended to decrease the mRNA levels of a predicted target gene, adenylate cyclase 9 (ADCY9; p = 0.06). …”