Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents by Yini Wang (410389)

“…Comparing 8a-treated CCRF-CEM leukemia cells with vehicle control (DMSO), 23 distinct metabolites involved in five metabolic pathways were identified. Metabolites from glutathione (GSH) and glycerophospholipid metabolism were investigated in detail, and results showed that GSH level and the reduced/oxidized glutathione (GSH/GSSG) ratio were significantly decreased in 8a-treated cells, while L-cysteinyl-glycine (L-Cys-Gly) and glutamate were greatly increased. …”

Impact of an Educational Program to Reduce Healthcare Resources in Community-Acquired Pneumonia: The EDUCAP Randomized Controlled Trial by Jordi Adamuz (812449)

“…The frequency of the composite primary end point was 23.5% following the individualized program and 42.9% following the conventional information (difference, -19.4%; 95% confidence interval, -6.5% to -31.2%; P = 0.003).…”

Data_Sheet_1_Revising Incidence and Mortality of Lung Cancer in Central Europe: An Epidemiology Review From Hungary.docx by Krisztina Bogos (7529174)

“…Age-adjusted incidence rates were 115.7–101.6/100,000 person-years among men (ESP 1976: 84.7–72.6), showing a mean annual change of − 2.26% (p = 0.008). …”

Averaged 24 h locomotor rest-activity profiles of control and STZ-diabetic mice (n = 12 for each group) maintained under 12L/12D cycle. by Hasna Lahouaoui (595100)

“…In the first experiment (upper panel), mice were exposed to 3 successive stepwise increases of light intensity (100, 300 lux and 1000 lux) whereas in the second experiment (lower panel), animals were exposed to decreases of light intensity (1000, 300 lux and 100 lux). …”

Supplementary Material for: Global, Regional, and National Burden of Neonatal Encephalopathy Due to Birth Asphyxia and Trauma, Its Attributable Risk Factors, 1990-2021: Results fro... by figshare admin karger (2628495)

“…Low SDI regions experienced a substantial 112.9% increase in NEBAT cases, while high-middle SDI regions witnessed a significant 34.8% decrease. …”

Gene expression profiling, for genes involved in regulating cell cycle, in A549, MCF-7 and HepG2 cells incubated with or without etoposide under normoxic or hypoxic conditions by Jean-Philippe Cosse (37121)

Altered Protein Expression in Post-MI Heart Muscle in GGF2-treated Rats Relative to Vehicle Controls. by Michael F. Hill (380769)

Gene expression profiling, for genes involved in regulating apoptosis, in A549, MCF-7 and HepG2 cells incubated with or without etoposide under normoxic or hypoxic conditions by Jean-Philippe Cosse (37121)

Table_1_Repurposing of Rutan showed effective treatment for COVID-19 disease.DOCX by Shavkat I. Salikhov (17471622)

“…There was no drug accumulation in experimental animals’ organs and tissues. A clinical study demonstrated a statistically significant decrease in the C-reactive protein and a reduction of the viremia period. …”

Data_Sheet_1_Repurposing of Rutan showed effective treatment for COVID-19 disease.docx by Shavkat I. Salikhov (17471622)

“…There was no drug accumulation in experimental animals’ organs and tissues. A clinical study demonstrated a statistically significant decrease in the C-reactive protein and a reduction of the viremia period. …”

ROS induction and survival of deletion mutants <i>cta1</i>Δ/Δ, <i>grx2</i>Δ/Δ and <i>trx1</i>Δ/Δ. by Pedro Miramón (108557)

“…Survival of the wild type strain was set to 100%. (B) a. ROS production in response to <i>trx1</i>Δ/Δ. …”

Image_1_Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis.tif by Jehan Alam (5577734)

“…The percentage of resident conjunctival monocytes (Ly6C⁺CD64^-) significantly decreased while CD64⁺MHCII⁺ macrophages increased over 5 days of DS (P<0.05 for both). …”

Image_2_Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis.tif by Jehan Alam (5577734)

“…The percentage of resident conjunctival monocytes (Ly6C⁺CD64^-) significantly decreased while CD64⁺MHCII⁺ macrophages increased over 5 days of DS (P<0.05 for both). …”

Acute Hypoglycemia Induces Retinal Cell Death in Mouse by Martine Emery (215947)

“…We then isolated retinas from each group at different time-points after the clamp to analyze cells apoptosis and genes regulation. …”

Hydrated Alkali Atoms on Copper(111): A Density Functional Theory Study by Alejandro Pérez Paz (9016370)

“…Beyond 5 coordinated water molecules, the alkali adatom becomes saturated, and water adsorption sets in on the Cu(111) surface with the expected decrease in the work function of the system, as measured in two-photon photoemission spectroscopy (2PPE) experiments. …”

SAP inhibits HMWHA-induced fibrocyte differentiation and potentiates LMWHA-induced fibrocyte inhibition. by Anu S. Maharjan (342245)

“…<p>(<b>A</b>) Human PBMC were cultured in different concentrations of HMWHA with 0, 0.1, 0.3, 1, and 3 µg/ml of SAP. …”

Stable expression of sh1CD81 downregulates surface CD81 expression and increases TCR mediated activation. by Safak Isil Cevik (115279)

“…<p>(<b>a</b>) GFP expression before and after puromycin selection in VL3.3M2 cell lines transfected with pLMP encoding CD81 shRNA (sh1CD81) shows the percentage of cells expressing CD81 shRNA. …”

Evaluation of emerging NASH therapies: the impact of treatment efficacy profiles on long-term health outcomes: Supplementary materials by William L Herring (14039541)

“…Hypothetical efficacy profiles were defined</p> <p>affecting resolution (100%-increase), fibrosis improvement (100% increase), or fibrosis worsening (50%</p> <p>decrease). …”

Effects of Parkia platycephala on feeding behavior, rumen health, blood markers, and physiological responses of lactating goats by Ianete Lima Batista (10446651)

“…At these replacement levels, the goats significantly spent more time feeding and ruminating. There was a significant decrease in the number of chews (number/day and number/min) with an increase in PP inclusion. …”

Image2_Differential modulation of lung aquaporins among other pathophysiological markers in acute (Cl2 gas) and chronic (carbon nanoparticles, cigarette smoke) respiratory toxicity... by Sukanta S. Bhattacharya (13872920)

“…SP-A and MUC5B expression showed a decreasing pattern across all toxicity models except the acute Cl₂ toxicity model, which showed a highly significant upregulation of MUC5B (25.95-fold; p = 0.003). …”