<i>CS</i> silencing affects AMPK/P38 MAPK pathway in ovarian cancer cell lines. by Lilan Chen (563264)

“…<p>(<b>A</b>) mRNA and <b>(B)</b> protein expression level of CS by real-time PCR and western blot in SKOV3 and A2780 cells after <i>CS</i> siRNA (100 nM) for 24 h and 48 h after transfection, respectively. …”

Thapsigargin versus glucose deprivation and F7 mRNA expression. by Katherine R. Cronin (146594)

“…<p>(<b>A-C</b>) HepG2 cells were treated in parallel for 24 hr in medium with 25 mM, 5 mM or 0 mM glucose (white bars, with the direction of arrows indicating decreasing concentration) or for 6 hr at 5 mM glucose without (-) or with (+) 500 nM TG (grey bars), and qRT-PCR was performed as described. …”

ENMD-1198 inhibits c-Src-mediated STAT3 activation. by Saad Yousuf (541082)

“…Densitometry was performed and the relative intensity when compared to Actin for lanes 1-8, respectively, were: RKIP (top band): 0.225, 0.32, 0.81, 0.22, 0.85, 0.22, 1.02, 0.76; RKIP (bottom band): 0.42, 0.5, 0.4, 0.73, 0.4, 0.59, 0.68, 0.6; STAT3 pY⁷⁰⁵: 0.41, 1.3, 0.31, 0.10, 0.81, 0.74, 0.20, 0.70; STAT3: 0.075, 0.048, 0.059, 0.049, 0.042, 0.044, 0.033, 0.071; c-Src pY⁴¹⁶: 0.22, 1.15, 0.59, 0.34, 0.75, 0.72, 0.16, 0.29; c-Src: 0.24, 0.37, 0.24, 0.31, 0.55, 0.31, 0.49, 0.5. …”

Table 1_Bevacizumab and anlotinib combination therapy acts via HIF-1α suppression to exert synergistic anti-angiogenic and anti-tumor effects in non-small cell lung cancer.docx by Nafeisha Simayi (22262161)

“…B+A inhibited cell viability by 78%, colony formation by 90%, and invasion by 75% in NSCLC cell lines A549 and H1299; downregulated N-cadherin 5.34-fold, vimentin 6.46-fold, and α-SMA 4.35-fold; and upregulated E-cadherin 3.75-fold. …”

Supplementary file 1_ZnO nanoparticles induce acute arrhythmia and heart failure in mice by disturbing cardiac ion channels.pdf by Xuexue Liu (3271641)

“…</p>Methods<p>Two different sizes of ZnO NPs (40 nm and 100 nm) were selected and their in vivo effects on mouse heart were evaluated by echocardiography and electrocardiograms. …”

shRNA-mediated knockdown of <i>Tsc2</i> expression in 3T3-L1 preadipocytes leads to enhanced mTORC1-dependent adipocyte differentiation. by Hui H. Zhang (262186)

“…<p>(A) 3T3-L1 preadipocytes with stable shRNA-mediated knockdown of <i>Tsc2</i> expression display elevated basal mTORC1 signaling and attenuation of insulin-stimulated Akt phosphorylation. 3T3-L1 preadipocytes stably expressing shRNAs targeting <i>Tsc2</i> (shTsc2), or firefly luciferase (shLuc) as a control, were serum-starved for 16 h and, where indicated, were pretreated with rapamycin for 15 min prior to stimulation with 100-nM insulin for 15 min. …”

Presentation1_Impact of the Southern Ecuadorian Andes on Oxygen and Hydrogen Isotopes in Precipitation.pdf by Aude Gébelin (10889514)

“…The results for the two domains show a decrease of δ¹⁸O with elevation which fits a linear regression with a slope of −0.18‰/100 m (R² = 0.73, n = 83). …”

Presentation_1_Hormetic effect of 17α-ethynylestradiol on activated sludge microbial community response.pdf by Phumudzo Budeli (5066495)

“…Although environmental concentrations showed a slight decrease in microbial counts (5.6 × 10⁶ to 4.6 × 10⁶ CFU/ml) after a 24-h incubation for the culturable approach, the predictive elevated concentrations (5 to 100 mg/L) revealed a drastic microbial counts reduction (5.6 × 10⁶ to 8 × 10² CFU/ml). …”

S4 Fig - by James M. Burke (14041162)

“…IGV trace scale was decreased 2.5x after autoscaling. (E) RNAs that are upregulated (padj < 0.5, Log2Fold Change > 1). …”

Relative expression of the oxygen stress-induced Hif1a, Sod1 and Nf-kB genes in S334ter-4 Rho retinas at different ages. by Vishal M. Shinde (178347)

“…Expression of the Hif1α and Sod1 genes was significantly induced in P10 S334ter-4 Rho compared to SD retinas (1.5- and 1.4-fold, respectively, <i>P</i><0.05, *). …”

Figure 7 by Joanna J. Moser (239569)

“…MRNA expression in U-87 astrocytoma cells were normalized to primary astrocytes mRNA expression. All mRNAs had a fold change >2.5 and were significantly expressed (p<0.01). …”

The coevolution of effort and replication, replicated and corrected by Florian Kohrt (13918527)

“…At this point the decline of effort has made low-effort novel research more attractive than low-effort replications (because publishing a novel positive result is associated with a higher payof than publishing a replication) and consequently the replication rate decreases again. …”

Image_2_Asymptomatic Bacterial Vaginosis Is Associated With Depletion of Mature Superficial Cells Shed From the Vaginal Epithelium.jpeg by D. Elizabeth O'Hanlon (8552298)

“…However, we observed that aBV smears contained significantly fewer shed cells (median 35/100X field) than no BV smears, p = 22.0e−16. …”

Table_1_Asymptomatic Bacterial Vaginosis Is Associated With Depletion of Mature Superficial Cells Shed From the Vaginal Epithelium.XLSX by D. Elizabeth O'Hanlon (8552298)

“…However, we observed that aBV smears contained significantly fewer shed cells (median 35/100X field) than no BV smears, p = 22.0e−16. …”

Image_1_Asymptomatic Bacterial Vaginosis Is Associated With Depletion of Mature Superficial Cells Shed From the Vaginal Epithelium.jpg by D. Elizabeth O'Hanlon (8552298)

“…However, we observed that aBV smears contained significantly fewer shed cells (median 35/100X field) than no BV smears, p = 22.0e−16. …”

Quantitative Venn diagram of proteins expressed in sera of patients with clinically significant portal hypertension (CSPH) and non-CSPH group. by Frane Pastrovic (18349349)

“…Abbreviations: ATX–Autotaxin; BPI–Bactericidal permeability increasing protein; CAT–Catalase; CD44 –Cluster of differentiation 44; FN1 –Fibronectin; HIST1H2BN–Histone H2B; HIST1H4A –Histone H4; LYVE1 –Lymphatic vessel endothelial hyaluronic acid receptor 1; MPO–Myeloperoxidase; NPNT–Nephronectin; PAI-1 –Plasminogen activator inhibitor 1; PRDX2 –Peroxiredoxin-2; S100-A9—Protein S100-A9.…”

Image_3_Compound small peptide of Chinese medicine alleviates cyclophosphamide induced immunosuppression in mice by Th17/Treg and jejunum intestinal flora.JPEG by Yuqing Cui (1529068)

“…<p>The aim of this study was to explore the efficacy of Compound small peptide of Chinese medicine (CSPCM) on cyclophosphamide (CTX) induced immunosuppression in mice. The 100 male Kunming mice were divided into 5 groups: group A (control group), group B (model group), group C (100 mg/kg.bw CSPCM), group D (200 mg/kg.bw CSPCM) and group E (400 mg/kg.bw CSPCM). …”

Effects of the mutant L29Q cTnC and SD cTnI determined by Molecular Dynamics simulations. by Alison Y. Li (486146)

“…The Ca²⁺ ion bound in site II is shown as a black sphere. (C) shows the largest movement caused by the L29Q mutation in the presence of the pseudo-phosphorylated cTnI, which is the re-orientation of helix A and helix B of cNTnC accompanied by a decrease of interhelical angle of 13°.…”

Small-diameter sensory neurons from mutant mice have relatively few deficits in chemical activation. by Katherine J. Zappia (3178827)

“…<p>(<b>A</b>) Calcium imaging of small-diameter DRG neurons revealed no difference in the percentage of neurons responding to the 100 μM of the TRPA1 agonist, cinnamaldehyde, when comparing control and mutant neurons. …”

Image_1_Compound small peptide of Chinese medicine alleviates cyclophosphamide induced immunosuppression in mice by Th17/Treg and jejunum intestinal flora.JPEG by Yuqing Cui (1529068)

“…<p>The aim of this study was to explore the efficacy of Compound small peptide of Chinese medicine (CSPCM) on cyclophosphamide (CTX) induced immunosuppression in mice. The 100 male Kunming mice were divided into 5 groups: group A (control group), group B (model group), group C (100 mg/kg.bw CSPCM), group D (200 mg/kg.bw CSPCM) and group E (400 mg/kg.bw CSPCM). …”