Huntingtons Disease Mice Infected with <i>Toxoplasma gondii</i> Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality by David W. Donley (3111198)

“…Prior to death, infected HD mice demonstrated decreased CD8+ T-lymphocyte proliferation in brain and spleen compared to wild-type infected mice. …”

Steady-State Spectroscopic Analysis of Proton-Dependent Electron Transfer on Pyrazine-Appended Metal Dithiolenes [Ni(pdt)₂], [Pd(pdt)₂], and [Pt(pdt)<sub>2</s... by Steven R. Kennedy (2920332)

“…For all three complexes, protonation results in severe attenuation of the electronic coupling, as measured by the IVCT band. We find nearly 5-fold decreases in electronic coupling for both Ni and Pt, while, for the Pd complex, the electronic coupling is reduced to the point that the IVCT band is no longer observable. …”

<b>Concurrent initiation of treadmill exercise protects against angiotensin II-induced renal injury by modulating oxidative stress and autophagy in mice</b> by Ji-Seok Kim (21287672)

“…The 4-week AngII group exhibited significantly increased fibrosis (~2-fold vs. Veh, p < 0.01), elevated TGF-β and iNOS expression, and disrupted autophagic flux, including increased LC3-II/I ratio and ATG expression, alongside decreased p62 levels. …”

The Putative C₂H₂ Transcription Factor MtfA Is a Novel Regulator of Secondary Metabolism and Morphogenesis in <i>Aspergillus nidulans</i> by Vellaisamy Ramamoorthy (459033)

“…However, in this case, over-expression of <i>mtfA</i> enhanced the transcription of penicillin genes, increasing penicillin production more than 5 fold with respect to the control. Importantly, in addition to its effect on secondary metabolism, <i>mtfA</i> also affects asexual and sexual development in <i>A. nidulans.…”

Steady-State Spectroscopic Analysis of Proton-Dependent Electron Transfer on Pyrazine-Appended Metal Dithiolenes [Ni(pdt)₂], [Pd(pdt)₂], and [Pt(pdt)<sub>2</s... by Steven R. Kennedy (2920332)

“…For all three complexes, protonation results in severe attenuation of the electronic coupling, as measured by the IVCT band. We find nearly 5-fold decreases in electronic coupling for both Ni and Pt, while, for the Pd complex, the electronic coupling is reduced to the point that the IVCT band is no longer observable. …”

Time to Definitive Health-Related Quality of Life Score Deterioration in Patients with Resectable Metastatic Colorectal Cancer Treated with FOLFOX4 versus Sequential Dose-Dense FOL... by Zeinab Hamidou (563982)

“…The TUDD was defined as the time interval between randomization and the first decrease in HRQoL score ≥ 5-point with no further improvement in HRQoL score ≥ 5 points or any further HRQoL data. …”

Treatment with a TRPV agonist reduces the ability of mf to establish infection in mosquitoes. by Nicolas J. Wheeler (8947214)

“…(B) Replication of blood-feeding experiments with 5 mM and 25 mM showed a significant increase in the proportion of blood-fed mosquitoes when blood was supplemented with 5 or 25 mM NAM. …”

Cisd2KO mice exhibit cardiac electromechanical dysfunctions that are similar to those observed in the naturally aged WT mice. by Chi-Hsiao Yeh (7474556)

“…Mouse number <i>n</i> ≥ 5 for each group. Values for each data point can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000508#pbio.3000508.s001" target="_blank">S1 Data</a>. 3M, 3 months old; 6M, 6 months old; 26M, 26 months old; APC, atrial premature complex; AV, atrioventricular; Cisd2KO, CDGSH iron-sulfur domain-containing protein 2 KO; ECG, electrocardiography; KO, knockout; MRI, magnetic resonance imaging; QTc, corrected QT; VPC, ventricular premature complex; WT, wild type.…”

File S1 - Deficiency of the Transcriptional Repressor B Cell Lymphoma 6 (Bcl6) Is Accompanied by Dysregulated Lipid Metabolism by Christopher R. LaPensee (571785)

“…B – Weights of male Bcl6 KO mice were significantly lower than WT littermates at 3, 4, and 5 weeks of age. Each point represents mean+SE for 4 WT (solid line) and 3 KO (dotted line) male mice. …”

Neuritin restores the reduction in the dendritic spine density and the maturity of individual spines in Tg2576 neurons. by Yoori Choi (611187)

“…Tg2576 neurons revealed a significant decrease particularly in type II spines (mushroom type; mature spines with a large head, >0.6 µm, and a short neck), but yielded a slightly higher density of type I spines (stubby type; less mature spines, relatively small spine head, <0.6 µm, and short neck, <0.3 µm) compared to the other groups. …”

Reproductive traits and body condition. by Mary Hagedorn (319120)

“…<b>A)</b> Body condition (K) did not correlate with sperm volume or <b>B)</b> motility, but <b>C</b>) increasing body condition (K) correlated with a decreasing sperm concentration. …”

Stochastic pulsing mediated by interlinked positive and negative feedback and tuned by inducer levels. by Javier Garcia-Bernardo (463578)

“…The salicylate-responsive variants (<i>Wildtype</i> and <i>Only Negative</i>) show a decrease in CV upon induction. (D) Noise strength (var/mean) of MarA as a function of salicylate. …”

DataSheet_1_Non-destructive quantification of key quality characteristics in individual grapevine berries using near-infrared spectroscopy.pdf by Lucie Cornehl (18977426)

“…This study focusses on predicting essential quality parameters like sugar and acid content in Vitis vinifera (L.) varieties ‘Chardonnay’, ‘Riesling’, ‘Dornfelder’, and ‘Pinot Noir’. A small near-infrared spectrometer was used measuring non-destructively in the wavelength range from 1 100 nm to 1 350 nm while the reference contents were measured using high-performance liquid chromatography. …”

Unraveling the Conformations of Backbone and Side Chains in Thermosensitive Bottlebrush Polymers by Karteek K. Bejagam (1609663)

“…The BBPs with 9, 36, and 72 bead backbones suggest that, with a decrease in the backbone length, even at 100% grafting density, PNIPAM chains exhibit a coil-like and a globule-like state at 290 and 320 K, respectively. …”

DataSheet1_Eluxadoline Versus Antispasmodics in the Treatment of Irritable Bowel Syndrome: An Adjusted Indirect Treatment Comparison Meta-analysis.PDF by Di Qin (107446)

“…The secondary efficacy outcome was the relief of global IBS symptoms, defined by a composite response of a decrease in abdominal pain and improvement in stool consistency on the same day for at least 50% of the days assessed. …”

Unraveling the Conformations of Backbone and Side Chains in Thermosensitive Bottlebrush Polymers by Karteek K. Bejagam (1609663)

“…The BBPs with 9, 36, and 72 bead backbones suggest that, with a decrease in the backbone length, even at 100% grafting density, PNIPAM chains exhibit a coil-like and a globule-like state at 290 and 320 K, respectively. …”

Normal learning and extinction in the model. by Remus Osan (3639754)

“…Freezing increases after learning of memory 2 (red bar), but decreases again (blue bar) after extinction learning (corresponding to a single reexposure session with <i>t</i> = 10). …”

Regulation of macroscopic Cx46 currents by external Ca and Mg by Vytas K. Verselis (53583)

“…(A) Representative current–voltage (I-V) relationships (top) at different external Ca concentrations ranging from nominal (0 added) to 1.8 mM were obtained by applying slow (3 min) voltage ramps from +50 to −100 mV to a Cx46-expressing oocyte. …”

Table_1_How Listeria monocytogenes Shapes Its Proteome in Response to Natural Antimicrobial Compounds.XLSX by Rosalba Lanciotti (6190814)

“…The survival of L. monocytogenes cells was not affected by the antimicrobials at the concentrations assayed, with the exception of ethanol (1% v/v) and thyme essential oil (100 mg/L), which decreased cell viability from 8.53 ± 0.36 to 7.20 ± 0.22 log CFU/mL (P = 0.04). …”

Table_2_How Listeria monocytogenes Shapes Its Proteome in Response to Natural Antimicrobial Compounds.docx by Rosalba Lanciotti (6190814)

“…The survival of L. monocytogenes cells was not affected by the antimicrobials at the concentrations assayed, with the exception of ethanol (1% v/v) and thyme essential oil (100 mg/L), which decreased cell viability from 8.53 ± 0.36 to 7.20 ± 0.22 log CFU/mL (P = 0.04). …”