Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents by Yujuan Li (554062)

“…Among these, Compound <b>13</b>, featuring an oxopropyl group at the <i>ortho</i>-position of quinone group, exhibited the most potent inhibitory effects on HCT116, PC9, and A549 cells, with IC₅₀ values decreasing from 5.27 to 1.18 μM (4.5-fold increase), 6.98 to 0.57 μM (12-fold increase), and 5.88 to 2.25 μM (2.6-fold increase), respectively, compared to compound <b>5</b>. …”

Presentation_1_Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Trea... by Anusha Ande (724831)

“…In the 3DD cell culture setting, sequential dosing of PAC then EVE+DAS showed a 5-fold increase in caspase-3 activity and 8.5-fold decrease in the total cell number compared to the control. …”

Transcriptomics identifies keratin filaments working downstream of mitochondrial Ca²⁺ dynamics to regulate melanogenesis. by Jyoti Tanwar (2230597)

“…Scale from blue to red represents z-score for fold change from −1 to +1. (G) Representative pellet images of siNT control and siKeratin 5 on LD day 6 (<i>N</i> = 3). …”

Table_2_Hypermethylated GRIA4, a potential biomarker for an early non-invasive detection of metastasis of clinically known colorectal cancer.docx by Eva Lukacova (14727829)

“…After tumor removal surgery, average hypermethylation decrease in plasma was 1.6× for primary (p=0.037) and 4.5× for metastatic patients (p=0.023).…”

Table_3_Hypermethylated GRIA4, a potential biomarker for an early non-invasive detection of metastasis of clinically known colorectal cancer.docx by Eva Lukacova (14727829)

“…After tumor removal surgery, average hypermethylation decrease in plasma was 1.6× for primary (p=0.037) and 4.5× for metastatic patients (p=0.023).…”

Table_1_Hypermethylated GRIA4, a potential biomarker for an early non-invasive detection of metastasis of clinically known colorectal cancer.docx by Eva Lukacova (14727829)

“…After tumor removal surgery, average hypermethylation decrease in plasma was 1.6× for primary (p=0.037) and 4.5× for metastatic patients (p=0.023).…”

Differentiation of mammary gland epithelial cells in control (<i>Ctr</i>) and <i>Miz1</i>Δ<i>POZ</i> tissue and in HC11 cells with reduced levels of Miz1. by Adrián Sanz-Moreno (172726)

“…The film was exposed 1 and 5 minutes, respectively. (<b>G</b>) PCR and (<b>H</b>) Western blots revealed a down-regulation of ß-casein when Miz1 concentration is decreased. …”

HCMV-Induced Changes in Glycolytic Metabolites by Joshua Munger (66985)

“…Transcriptional data are depicted graphically at the relevant enzymatic step by the following symbols (shown in red): +, increased and −, decreased ≥1.5-fold in HCMV infection versus mock infection and <i>p</i> < 0.05 based on ANOVA analysis; NC, no change, either not significant by ANOVA or effect of HCMV < 1.5-fold. …”

Astrocytic volume changes in the cortex of GFAP/EGFP and GFAP/EGFP/α-Syn^−/− mice during hypoosmotic stress. by Miroslava Anderova (155561)

“…The changes of astrocytic volume during washout were evaluated in each individual cell and expressed as an average percent of cell volume increase/decrease related to the maximal volume after 30 minutes of aCSF_H-50 (<b>C right</b>) or aCSF_H-100 (<b>D right</b>) exposure; these values were set as 0%. …”

Validation of the primary screen hits with secondary luciferase-based invasion and red-green invasion assays. by Rajshekhar Y. Gaji (417441)

“…The values obtained with non-targeting siRNA controls were set at 100% invasion. A total of 81 genes (red asterisks) showed significant decrease (<i>p</i><0.05, one sample <i>t</i>-test) in parasite invasion compared to NTsiRNA controls. …”

Expression of MMP7 and TIMP1 in wounds. by Katharina Sommer (463202)

“…Septic animals show a significant decrease in MMP7 expression on day 2 and 6 compared to control mice. …”

Characterisation and influence of the content of waste foundry sand on rendering mortars by Juliana Machado Casali (4696111)

“…The results demonstrated that the waste foundry sand had an influence on the properties of the mortars in fresh state (mainly for the mortar with 100% waste foundry sand, which required the use of a larger amount of water to obtain the same consistence) and in the hardened state (decrease in strength, mass density and modulus of elasticity). …”

Ca²⁺ sparklets in DSM are affected by, but not dependent upon, signals from the SR. by Peter Sidaway (190696)

“…In the presence of the VGCC antagonist R-(+)-Bay K 8644 (1 μM) and CPA (10 μM), there was a significant decrease in the frequency (D) but not amplitude (E) of Ca²⁺ sparklets. …”

Glycosylation inhibitors block thrombin-induced sRBC adhesion to HUVECs. by Pushpankur Ghoshal (580530)

“…The level of sRBC adhesion to untreated HUVECs was set to 100%. **, p<0.0001 <b>B</b>. Glycosylation inhibitors decrease thrombin-induced sRBC adhesion to HUVECs. …”

Change in the number of attractors during the learning process. by Tomoki Kurikawa (228085)

“…In the early stages of the learning process, the number of fixed-point attractors increases, while in the later stage (after 5 or 6 learning steps), the number of fixed-point attractors decreases (fixed-point attractors are replaced by limit-cycle attractors).…”

Histology of islet allografts at day 10, 17, 24, and 31 after transplantation in non-diabetic mice. by Jyuhn-Huarng Juang (407970)

“…There was profound immune cell infiltration at day 10 and 17, and a decrease in graft size at day 24 and 31 in the CSPIO-labeled islet graft. …”

Gene expression in primary human skeletal muscle cells after treatment with acylcarnitines. by Rainer Lehmann (141280)

“…<p>mRNA expression of PGC-1α (A), CPT1b (B), CD36 (C), COX1 (D) and AngPL-4 (E) related to β-actin mRNA levels after incubation with 100 µM L-carnitine (L-C), an equimolar mixture of C8:0-, C10:0- and C12:0-acylcarnitine (total 100 µM; AC), 60 µM palmitate (p), or p and AC as indicated. …”

Effect of galactose treatment on oleic acid metabolism. by Eili Tranheim Kase (177084)

“…Suppressibility, defined as the ability of the cells to decrease oleic acid oxidation by acutely added glucose, was calculated as: [(1-(oxidation of oleic acid at 5 mM glucose/oxidation of oleic acid at no glucose added))×100%]. …”

Tarsal platform show after upper eyelid blepharoplasty with or without brassiere sutures by Marisa Novaes de Figueiredo (4703455)

“…We conducted a study to evaluate the efficacy of upper blepharoplasty with or without a technique (brassiere sutures) to increase TPS and decrease BFS. …”

The effect of ribavirin (Rib) and guanosine (Gua) on HCV infectious progeny production and intracellular viral RNA and nucleotide pools. by Ana M. Ortega-Prieto (446894)

“…(c) Left: intracellular amount of the four nucleoside-triphosphates, following 72 h of exposure to either Rib or Gua, as indicated at the bottom. Right: decrease or increase of nucleotide concentration as a result of exposure to Gua or Rib; note that the maximum decrease possible is 100%. …”