Enzyme Replacement in a Human Model of Mucopolysaccharidosis IVA <em>In Vitro</em> and Its Biodistribution in the Cartilage of Wild Type Mice by Melita Dvorak-Ewell (243772)

“…MPS IVA chondrocyte GALNS activity was not detectable and the cells exhibited KS storage up to 11-fold higher than unaffected chondrocytes. MPS IVA chondrocytes internalized rhGALNS into lysosomes, resulting in normalization of enzyme activity and decrease in KS storage. rhGALNS treatment also modulated gene expression, increasing expression of chondrogenic genes <em>Collagen II, Collagen X</em>, <em>Aggrecan</em> and <em>Sox9</em> and decreasing abnormal expression of <em>Collagen I</em>. …”

The Intensity of IUGR-Induced Transcriptome Deregulations Is Inversely Correlated with the Onset of Organ Function in a Rat Model by Daniel Vaiman (83223)

“…We show that (1) expressional alterations are apparently stronger in organs functioning late in foetal or postnatal life than in organs that are functioning early (2) hierarchical classification of the deregulations put together kidney and placenta in one cluster, liver, lungs and heart in another; (3) the epigenetic machinery is set up especially in the placenta, while its alterations are rather mild in other organs; (4) the genes appear deregulated in chromosome clusters; (5) the altered expression cascades varies from organ to organ, with noticeably a very significant modification of the complement and coagulation cascades in the kidney; (6) we found a significant increase in TF binding site for HNF4 proteins specifically for liver genes that are down-regulated in IUGR, suggesting that this decrease is achieved through the action of HNF transcription factors, that are themselves transcriptionnally induced in the liver by IUGR (x 1.84 fold). …”

Involvement of the Clock Gene <i>Rev-erb alpha</i> in the Regulation of Glucagon Secretion in Pancreatic Alpha-Cells by Elaine Vieira (174928)

“…At 0.5 mM glucose, alphaTC1-9 cells exhibited intrinsic circadian <i>Rev-erb alpha</i> expression oscillations that were inhibited by 11 mM glucose. …”

Data_Sheet_1_Improved Microbial Community Characterization of 16S rRNA via Metagenome Hybridization Capture Enrichment.PDF by Megan S. Beaudry (10705500)

“…These baits cover the diversity of all 16S rRNA sequences available in the Greengenes (v. 13.5) database, with no sequence having <78% sequence identity to at least one bait for all segments of 16S. …”

Restructuring the Crystalline Cellulose Hydrogen Bond Network Enhances Its Depolymerization Rate by Shishir P. S. Chundawat (2163151)

“…This rearrangement of the hydrogen bond network within cellulose III_I, which increased the number of solvent-exposed glucan chain hydrogen bonds with water by ∼50%, was accompanied by enhanced saccharification rates by up to 5-fold (closest to amorphous cellulose) and 60–70% lower maximum surface-bound cellulase capacity. …”

Supplementary Material for: Flavonoid Quercetin Enhances Nuclear factor erythroid 2-related factor 2 (Nrf2) Pathway Activation and Reduces Inflammatory Cytokines in Asthmatic Airwa... by figshare admin karger (2628495)

“…Additionally, bulk RNA-seq differential expression testing was performed, where a significant between-group difference was defined by a false discovery rate (FDR) < 0.05 and an absolute value of the log2 fold change > 0.5 Results: Human airway epithelial cells treated with quercetin showed a significant increase in Nrf2 protein levels compared to untreated cells (p=0.008). …”

Restructuring the Crystalline Cellulose Hydrogen Bond Network Enhances Its Depolymerization Rate by Shishir P. S. Chundawat (2163151)

“…This rearrangement of the hydrogen bond network within cellulose III_I, which increased the number of solvent-exposed glucan chain hydrogen bonds with water by ∼50%, was accompanied by enhanced saccharification rates by up to 5-fold (closest to amorphous cellulose) and 60–70% lower maximum surface-bound cellulase capacity. …”

DataSheet_1_Engineered nanoceria alleviates thermally induced oxidative stress in free-living Breviolum minutum (Symbiodiniaceae, formerly Clade B).zip by Liza M. Roger (10652156)

“…A clear ROS scavenging effect of the nanoceria was observed, with a 5-fold decrease in intracellular ROS levels during thermal stress. …”

Correlating Global Gene Regulation to Angiogenesis in the Developing Chick Extra-Embryonic Vascular System by Sophie Javerzat (257199)

“…Seven percent of analyzed genes showed a significant change in expression (>2-fold, FDR<5%) with a peak occurring from E7 to E10, when key morphogenetic and angiogenic genes such as BMP4, SMO, HOXA3, EPAS1 and FGFR2 were upregulated, reflecting the state of an activated endothelium. …”

Image2.JPEG by Muhammad I. Waris (5093375)

“…The NlugCSP8 mRNA was also highly expressed in the abdomen of unmated 5-day brachypterous males and correlated to the age, gender, adult wing form, and mating status. …”

Identified RNA splice junctions (SJ) with ≥10 splice reads from the KSHV WT or 57KO genome in BCBL-1 cells. by Vladimir Majerciak (485025)

“…<p>The positions of 5′ and 3′ splice sites (SS) are based on the KSHV reference genome GenBank Acc. …”

Data_Sheet_1_A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter bauman... by Sung-Pang Chen (10990884)

“…A D-form peptide, pepdD2, in which the D-enantiomers replaced the L-enantiomers of the Lys(K) and Leu(L) residues, extended the peptide half-life in plasma by more than 12-fold. PepD3 is 3-residue shorter than pepD2. Decreasing peptide length did not affect antimicrobial activity but increased the IC₅₀ to HEK293 cells, thus increased the selectivity index (SI) between A. baumannii and HEK293 cells from 4.7 to 8.5. …”

Restructuring the Crystalline Cellulose Hydrogen Bond Network Enhances Its Depolymerization Rate by Shishir P. S. Chundawat (2163151)

“…This rearrangement of the hydrogen bond network within cellulose III_I, which increased the number of solvent-exposed glucan chain hydrogen bonds with water by ∼50%, was accompanied by enhanced saccharification rates by up to 5-fold (closest to amorphous cellulose) and 60–70% lower maximum surface-bound cellulase capacity. …”

IL‑6 Linkage to Exercise-Induced Shifts in Lipid-Related Metabolites: A Metabolomics-Based Analysis by David C. Nieman (322662)

“…Vastus lateralis muscle biopsy and blood samples were collected before and immediately after running and showed a 33.7 ± 4.2% decrease in muscle glycogen, 39.0 ± 8.8-, 2.4 ± 0.3-, and 1.4 ± 0.1-fold increases in plasma IL-6, IL-8, and MCP-1, respectively, and 95.0 ± 18.9 and 158 ± 20.6% increases in cortisol and epinephrine, respectively (all, <i>P</i> < 0.001). …”

Nafion-Mediated Proton Transfer Facilitates the Electroreduction of SO₂ to H₂S by Hui Liu (33624)

“…It was observed that Nafion shortens the hydrogen bonds with water molecules in the electrolyte via its sulfonic acid groups, benefiting the proton transfer and consequently increasing the proton density on the electrode surface by 5-fold. With the Nafion-modified catalyst, the H₂S partial current density and separation efficiency reached 205.9 mA·cm^–2 (1.01 mmol·cm^–2·h^–1) and 87.8%, which were 1.34 and 1.22 times that on unmodified Cu, respectively. …”

Data_Sheet_1_A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter bauman... by Sung-Pang Chen (10990884)

“…A D-form peptide, pepdD2, in which the D-enantiomers replaced the L-enantiomers of the Lys(K) and Leu(L) residues, extended the peptide half-life in plasma by more than 12-fold. PepD3 is 3-residue shorter than pepD2. Decreasing peptide length did not affect antimicrobial activity but increased the IC₅₀ to HEK293 cells, thus increased the selectivity index (SI) between A. baumannii and HEK293 cells from 4.7 to 8.5. …”

Restructuring the Crystalline Cellulose Hydrogen Bond Network Enhances Its Depolymerization Rate by Shishir P. S. Chundawat (2163151)

“…This rearrangement of the hydrogen bond network within cellulose III_I, which increased the number of solvent-exposed glucan chain hydrogen bonds with water by ∼50%, was accompanied by enhanced saccharification rates by up to 5-fold (closest to amorphous cellulose) and 60–70% lower maximum surface-bound cellulase capacity. …”

Quantitative real-time PCR analysis of <i>B</i>. <i>burgdorferi</i> load in mice co-inoculated with 1–10 μM of <i>rIxs</i>S17. by Thu-Thuy Nguyen (9325402)

“…<i>burgdorferi</i> only (10⁴ spirochetes) with or without different amounts of <i>rIxs</i>S17 (1-2-5-10 μM). At 21 days post inoculation, <i>B</i>. …”

Data Sheet 1_Development of an LC-MS/MS method for astaxanthin quantification in shrimp tissues and its application to detect astaxanthin variations during ovary development stages... by Shuo Diao (1967698)

“…However, a significant redistribution of astaxanthin was observed during the post-developmental stage, characterized by a substantial decrease to 5.74 μg/g in the hepatopancreas, concomitant with an increase to 7.47 μg/g in ovarian tissue.…”

Table1.DOCX by Muhammad I. Waris (5093375)

“…The NlugCSP8 mRNA was also highly expressed in the abdomen of unmated 5-day brachypterous males and correlated to the age, gender, adult wing form, and mating status. …”