Treatment with a TRPV agonist reduces the ability of mf to establish infection in mosquitoes. by Nicolas J. Wheeler (8947214)

“…(B) Replication of blood-feeding experiments with 5 mM and 25 mM showed a significant increase in the proportion of blood-fed mosquitoes when blood was supplemented with 5 or 25 mM NAM. …”

Cisd2KO mice exhibit cardiac electromechanical dysfunctions that are similar to those observed in the naturally aged WT mice. by Chi-Hsiao Yeh (7474556)

“…Mouse number <i>n</i> ≥ 5 for each group. Values for each data point can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000508#pbio.3000508.s001" target="_blank">S1 Data</a>. 3M, 3 months old; 6M, 6 months old; 26M, 26 months old; APC, atrial premature complex; AV, atrioventricular; Cisd2KO, CDGSH iron-sulfur domain-containing protein 2 KO; ECG, electrocardiography; KO, knockout; MRI, magnetic resonance imaging; QTc, corrected QT; VPC, ventricular premature complex; WT, wild type.…”

File S1 - Deficiency of the Transcriptional Repressor B Cell Lymphoma 6 (Bcl6) Is Accompanied by Dysregulated Lipid Metabolism by Christopher R. LaPensee (571785)

“…B – Weights of male Bcl6 KO mice were significantly lower than WT littermates at 3, 4, and 5 weeks of age. Each point represents mean+SE for 4 WT (solid line) and 3 KO (dotted line) male mice. …”

Neuritin restores the reduction in the dendritic spine density and the maturity of individual spines in Tg2576 neurons. by Yoori Choi (611187)

“…Tg2576 neurons revealed a significant decrease particularly in type II spines (mushroom type; mature spines with a large head, >0.6 µm, and a short neck), but yielded a slightly higher density of type I spines (stubby type; less mature spines, relatively small spine head, <0.6 µm, and short neck, <0.3 µm) compared to the other groups. …”

Functional Characterization of AbeD, an RND-Type Membrane Transporter in Antimicrobial Resistance in <i>Acinetobacter baumannii</i> by Vijaya Bharathi Srinivasan (148478)

“…</p><p>Results</p><p>The <i>abeD</i> mutant displayed ~ 3.37 fold decreased survival and >5-fold reduced growth in hostile osmotic (0.25 M; NaCl) and oxidative (2.631 μM–6.574 μM; H₂O₂) stress conditions respectively. …”

Reproductive traits and body condition. by Mary Hagedorn (319120)

“…<b>A)</b> Body condition (K) did not correlate with sperm volume or <b>B)</b> motility, but <b>C</b>) increasing body condition (K) correlated with a decreasing sperm concentration. …”

Stochastic pulsing mediated by interlinked positive and negative feedback and tuned by inducer levels. by Javier Garcia-Bernardo (463578)

“…The salicylate-responsive variants (<i>Wildtype</i> and <i>Only Negative</i>) show a decrease in CV upon induction. (D) Noise strength (var/mean) of MarA as a function of salicylate. …”

Huntingtons Disease Mice Infected with <i>Toxoplasma gondii</i> Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality by David W. Donley (3111198)

“…Prior to death, infected HD mice demonstrated decreased CD8+ T-lymphocyte proliferation in brain and spleen compared to wild-type infected mice. …”

Steady-State Spectroscopic Analysis of Proton-Dependent Electron Transfer on Pyrazine-Appended Metal Dithiolenes [Ni(pdt)₂], [Pd(pdt)₂], and [Pt(pdt)<sub>2</s... by Steven R. Kennedy (2920332)

“…For all three complexes, protonation results in severe attenuation of the electronic coupling, as measured by the IVCT band. We find nearly 5-fold decreases in electronic coupling for both Ni and Pt, while, for the Pd complex, the electronic coupling is reduced to the point that the IVCT band is no longer observable. …”

<b>Concurrent initiation of treadmill exercise protects against angiotensin II-induced renal injury by modulating oxidative stress and autophagy in mice</b> by Ji-Seok Kim (21287672)

“…The 4-week AngII group exhibited significantly increased fibrosis (~2-fold vs. Veh, p < 0.01), elevated TGF-β and iNOS expression, and disrupted autophagic flux, including increased LC3-II/I ratio and ATG expression, alongside decreased p62 levels. …”

The Putative C₂H₂ Transcription Factor MtfA Is a Novel Regulator of Secondary Metabolism and Morphogenesis in <i>Aspergillus nidulans</i> by Vellaisamy Ramamoorthy (459033)

“…However, in this case, over-expression of <i>mtfA</i> enhanced the transcription of penicillin genes, increasing penicillin production more than 5 fold with respect to the control. Importantly, in addition to its effect on secondary metabolism, <i>mtfA</i> also affects asexual and sexual development in <i>A. nidulans.…”

Steady-State Spectroscopic Analysis of Proton-Dependent Electron Transfer on Pyrazine-Appended Metal Dithiolenes [Ni(pdt)₂], [Pd(pdt)₂], and [Pt(pdt)<sub>2</s... by Steven R. Kennedy (2920332)

“…For all three complexes, protonation results in severe attenuation of the electronic coupling, as measured by the IVCT band. We find nearly 5-fold decreases in electronic coupling for both Ni and Pt, while, for the Pd complex, the electronic coupling is reduced to the point that the IVCT band is no longer observable. …”

Unraveling the Conformations of Backbone and Side Chains in Thermosensitive Bottlebrush Polymers by Karteek K. Bejagam (1609663)

“…The BBPs with 9, 36, and 72 bead backbones suggest that, with a decrease in the backbone length, even at 100% grafting density, PNIPAM chains exhibit a coil-like and a globule-like state at 290 and 320 K, respectively. …”

DataSheet1_Eluxadoline Versus Antispasmodics in the Treatment of Irritable Bowel Syndrome: An Adjusted Indirect Treatment Comparison Meta-analysis.PDF by Di Qin (107446)

“…The secondary efficacy outcome was the relief of global IBS symptoms, defined by a composite response of a decrease in abdominal pain and improvement in stool consistency on the same day for at least 50% of the days assessed. …”

Unraveling the Conformations of Backbone and Side Chains in Thermosensitive Bottlebrush Polymers by Karteek K. Bejagam (1609663)

“…The BBPs with 9, 36, and 72 bead backbones suggest that, with a decrease in the backbone length, even at 100% grafting density, PNIPAM chains exhibit a coil-like and a globule-like state at 290 and 320 K, respectively. …”

Normal learning and extinction in the model. by Remus Osan (3639754)

“…Freezing increases after learning of memory 2 (red bar), but decreases again (blue bar) after extinction learning (corresponding to a single reexposure session with <i>t</i> = 10). …”

The role of PKCδ in thrombin-induced endothelial barrier disruption. by Lishi Xie (232227)

“…<p><b>(A)</b> Cells were treated with thrombin (1 U/ml, 15 min) or PMA (100 nM, 30 min) with unstimulated cells (Unstim) used as controls. …”

Regulation of macroscopic Cx46 currents by external Ca and Mg by Vytas K. Verselis (53583)

“…(A) Representative current–voltage (I-V) relationships (top) at different external Ca concentrations ranging from nominal (0 added) to 1.8 mM were obtained by applying slow (3 min) voltage ramps from +50 to −100 mV to a Cx46-expressing oocyte. …”

VEGF knockdown mouse model. by Delma Veron (151378)

“…(E) Low magnification VEGF immunohistochemistry shows absence of VEGF in some glomeruli in VEGF knockdown mice (right), (scale bar = 40 µm). (F) Glomerular VEGF-A (VEGF⁺ area/glomerular area x100) in VEGF knockdown mice (n = 135) decreases to ∼30% of controls (n = 118). …”

Flood return intervals for different scenarios of land cover and climate change. by Jeanne L. Nel (560902)

“…For example, the return period of a flood with a daily flow of 150 mm (similar to the May 1981 flood in this area) would decrease from a baseline of more than 100 years to 70 years under future climate (scenario 5).…”