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    Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity by Elizabeth S. Childress (2116453)

    Published 2017
    “…Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with its five G-protein coupled receptors (S1P<sub>1–5</sub>) to regulate cell growth and survival and has been implicated in a variety of diseases including cancer and sickle cell disease. …”
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