Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone by Ina Gielisch (1348827)

“…We report a rapid LC–MS-based method for the relative quantification of targeted metabolome profiling with an additional layer of confidence by applying multiple reaction monitoring (MRM) ion ratios for further identity confirmation and robustness. …”

The increased VACV replication in cultured cells is DUSP1 specific. by Ana Cáceres (50253)

“…Samples were collected at 0, 24 and 48 hours and viral titers were determined by immunostaining plaque assay in DF-1 cell line. Lower panel shows fold decrease of DUSP1 mRNA levels in siRNA-treated cells compared to mRNA levels in scramble siRNA-treated cells. …”

DCA effects on Pluripotency. by Ana Sofia Rodrigues (491559)

“…These results mirror the protein levels regarding CTR w/o LIF and DCA 5 mM. Four independent experiments were performed. …”

Pharmacokinetics and apparent Michaelisconstant for metabolite conversion ofsorafenib in healthy and hepatocellularcarcinoma-bearing rats: Supplementary figure by Hongxin Cai (18257618)

“…Results: Both the maximum serum</p><p dir="ltr">concentrations (2.5-times) and the area under the serum concentration–time curve from 0 h to infinity</p><p dir="ltr">(4.5-times) of SRF were observed to be significantly higher, with a greater than 3.0-fold decrease in</p><p dir="ltr">the clearance rate in the HCC-bearing rats compared with these values in healthy animals. …”

The expression of <i>GCG</i>, <i>NMES-1</i>, <i>LRMP</i>, and <i>FAM161B</i> genes, tested on independent laser microdissected colonic and also on demethylated HT-29 cells by real-... by Sándor Spisák (123726)

“…Genes were considered to be downregulated with values lower than 0.5 (50% decrease, horizontal dotted line), and upregulated with values higher than 2 (two-fold increase). …”

Several diverse DDR factors are differentially important for Alt-EJ relative to an EJ event that is a composite of Alt-EJ and c-NHEJ (Distal-EJ). by Sean M. Howard (687174)

“…(<b>D</b>) Each siRNA shown in C causes a decrease in target mRNA. Shown is the fold depletion of target mRNA after siRNA treatment, as quantified by qRT-PCR (2^ΔΔCt, based on normalization to actin and siCTRL treated cells).…”

Cell death is triggered at nighttime as part of the diurnal synchronized program of <i>D.salina</i>. by Mónica V. Orellana (411329)

“…Red line is Savitsky-Golay smoothed (span of 5) average of two replicate measurements for each time point.…”

Representative correlations between MV and EtCO₂. by Jaideep H. Mehta (3779440)

“…Specifically, a 1 L/min increase in MV led to 2.0 mmHg decrease in EtCO₂ (EtCO₂ instrument sensitivity = 2.0 ^mmHg/_L/min, corresponding with θ_PS = -63.5°).…”

Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs) by Jie Qian (565984)

“…Giving ethanol (5%) in drinking water to WT mice induced an increase in the expression of α5 and β4 mRNAs in circumvallate TRCs with a significant decrease in the expression of α3, α6 and β2 mRNAs. …”

Relative activities of oxidizing enzymes in activated sludge during the stable stage. by Cong Jiang (3175146)

“…The relative activity is less 100% indicating a decrease of enzyme activity (compared to the control). asterisks (*) indicating the statistical difference from the control (<i>p</i> < 0.05).…”

Effect of pulse electrical field on tumor absolute impedance. by Yossi Mandel (289945)

“…Impedance was measured at frequencies of 100 Hz–100 kHz. Pulsed electrical field caused a 4-fold decrease in absolute tumor impedance and loss of frequency relaxation, suggestive of membrane breakdown. …”

Triple-combination therapy for cutaneous leishmaniasis using detergent-free, hyaluronate-coated elastic nanovesicles - Supplementary data set by Kashif Iqbal (6504587)

“…H-ENVs improved</p> <p>the efficacy of paromomycin against promastigote and amastigote models of leishmaniasis by 4- and</p> <p>7.5-fold, respectively. In vivo investigation of H-ENVs demonstrated efficient topical management of</p> <p>cutaneous leishmaniasis. …”

IL1-β effects on protein expression in lipid raft- and non-lipid raft fractions. by Myriam Chentouf (346845)

“…</p><p>Up or down regulated membrane lipid raft and non lipid raft proteins after IL-1β treatment are presented in relative values recorded for the same proteins expressed in raft and non raft fraction in control condition (no IL-1β treatment). A 2-fold increase or decrease (bold) taken as cut-off value (positive or negative) is considered as significant.…”

Volcano plots. by Joe L. Webb (9596478)

“…<p>Genes upregulated (green) or downregulated (red) by WE consumption, correspond to a 1.5 decrease or increase in log fold changes. Each panel corresponds to a tissue in a given genotype: A) lean adipose; B) lean PFC; C) lean kidney; D) lean liver; E) ZDF adipose; F) ZDF PFC; G) ZDF kidney; and H) ZDF liver.…”

Kinase activity. by James W. Bruce (10204626)

“…<p>Kinase activities from the phosphorylation log2 fold changes at 5 min using PhosFate Profiler. PhosFate Profiler computes an enrichment score for kinases using the Kolmogorov–Smirnov statistical test, a p-value, and a kinase activity, where a positive score indicates an increase and a negative score a decrease in kinase activity.…”

Calcitonin inhibits osteoclast apoptosis through Bcl-2 and Erk signaling. by Yi-Jie Kuo (316801)

“…Protein levels were quantified by densitometry, corrected for the sample load based on actin expression, and expressed as fold-increase or decrease relative to the control lane. …”

HuR regulates expression of Eph/ephrins. by Jennifer Winter (87429)

“…Quantification of bands (Against GAPDH) was performed using the Image Quant software 5.2 (lower panel). Fold increase or decrease of expression are depicted.…”

Nuclear progestin receptor is up-regulated by estrogen in both the developing and adult brain. by Nicolas Diotel (338556)

“…<p>Fold induction of <i>pgr</i> expression after treatment of adult zebrafish with an aromatase inhibitor (A, 10⁻⁶ M of ATD) or estradiol (B, 10⁻⁷ M of 17β-estradiol), and larvae with E2 (C, 10⁻⁸ M of 17β-estradiol). …”

Significant changes (P≤0.05, FC ≥2) of fatty acids in <i>Mesorhizobium</i> N₃₃ exposed to cold. by Abdollah Ghobakhlou (503529)

“…Arrows indicate change in concentration: green-increase, red-decrease. FC =  fold changes; NA =  no significant change.…”

DNA binding activity of RegX3. by Gretta Roberts (217668)

“…Panels B-iii, C-v; and D-vii refer to competition experiments carried out in the presence of 100-fold excess non-labeled promoter fragments. …”