Unpaired adenosines exclusive to Bacteria 16S rRNAs. by Chaitanya Muralidhara (223748)

“…<p>The 100 positions identified in the A nucleotide segment of the second 16S eigenorganism with the largest decrease in relative nucleotide frequency include all 50 positions (red) in the alignment with unpaired A nucleotides exclusively conserved in the Bacteria. …”

Characterization of cribriform PIN/CIS lesions in the Lo-MYC mouse model. by Tsuyoshi Iwata (252556)

“…Yellow arrowhead shows intact smooth muscle layer around a PIN gland (C–D, original magnification 100×). …”

Constitutive promoter activity in long term culture of undifferentiated hESCs. by Karin Norrman (242990)

“…Intensity was measured by FACS analysis and EF1α promoter showed a significant decrease in intensity of eGFP expression from day 0 to day 50 (*p<0,014 students t'test). …”

Effects of transcriptional or translational inhibition on GRK6 mRNA expression. by Maike Stegen (8578665)

“…<p>(A) Treatment with actinomycin D causing an inhibition of transcriptional activity in serum starved Jurkat cells over 6 hours led to an increase in mRNA expression in comparison to treatment with 100 nM PMA only. …”

(-)-Oleocanthal treatment inhibits HGF-induced Met activation, stabilizes the epithelial phenotype, and reduces mesenchymal phenotype in breast cancer cells. by Mohamed R. Akl (566987)

“…SU11274 was used as a positive control. (<b>B</b>) Western blot analysis. (-)-Oleocanthal resulted in a marked increase in the level of epithelial markers E-cadherin and Zo-1 in MDA-MB-231, MCF-7, and BT-474 cells and a decrease of mesenchymal marker vimentin expression (in MDA-MB-231 cells) compared to the vehicle-treated control groups. (-)-Oleocanthal treatment resulted in downregulation of β-catenin in MCF-7 and BT-474 cells. …”

Nutrient supply shifts the relationship between RNA/Protein ratio and growth rate in chemostat. by Zhiyuan Li (205620)

“…Starting from the P-limited condition, data for decreasing the supply concentration of nitrogen by 2, 5, and 10-fold are shown as solid dots and corresponding best-fit lines. …”

CD45⁺ cells, including T cells, infiltrate skeletal muscle after CTX injury. by Alessandra Castiglioni (748889)

“…(B) The number of CD45⁺ cells in skeletal muscle peaks at day 3 and rapidly decreases thereafter (n ≥ 3 mice per time point, mean ± SEM). …”

Ketogenic compensation in <i>ATP6¹</i> animals. by Alicia M. Celotto (203614)

“…D) Quantitation of beta-hydroxybutyrate shows a marked increase in young animals with a decreasing trend with age compared with wildype. N = 9 wildtype day1–2, N = 5 wildtype days 13 and 20. …”

Functional Characterization of AbeD, an RND-Type Membrane Transporter in Antimicrobial Resistance in <i>Acinetobacter baumannii</i> by Vijaya Bharathi Srinivasan (148478)

“…</p><p>Results</p><p>The <i>abeD</i> mutant displayed ~ 3.37 fold decreased survival and >5-fold reduced growth in hostile osmotic (0.25 M; NaCl) and oxidative (2.631 μM–6.574 μM; H₂O₂) stress conditions respectively. …”

Co-culture assays of human bronchial epithelial cells (HBEC) and human lung microvascular endothelial cells (HMVEC-L). by Duy T. Dao (5349254)

“…HMVEC-L treated with VEGF₁₆₅ show upregulation of proteases such as cathepsin B and V, matrix metalloprotease (MMP)-7, CD10, and kallikrein 13 (B) as well as a more than 6-fold increase in HB-EGF concentration in the conditioned medium (C). …”

Huntingtons Disease Mice Infected with <i>Toxoplasma gondii</i> Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality by David W. Donley (3111198)

“…Prior to death, infected HD mice demonstrated decreased CD8+ T-lymphocyte proliferation in brain and spleen compared to wild-type infected mice. …”

Steady-State Spectroscopic Analysis of Proton-Dependent Electron Transfer on Pyrazine-Appended Metal Dithiolenes [Ni(pdt)₂], [Pd(pdt)₂], and [Pt(pdt)<sub>2</s... by Steven R. Kennedy (2920332)

“…For all three complexes, protonation results in severe attenuation of the electronic coupling, as measured by the IVCT band. We find nearly 5-fold decreases in electronic coupling for both Ni and Pt, while, for the Pd complex, the electronic coupling is reduced to the point that the IVCT band is no longer observable. …”

<b>Concurrent initiation of treadmill exercise protects against angiotensin II-induced renal injury by modulating oxidative stress and autophagy in mice</b> by Ji-Seok Kim (21287672)

“…The 4-week AngII group exhibited significantly increased fibrosis (~2-fold vs. Veh, p < 0.01), elevated TGF-β and iNOS expression, and disrupted autophagic flux, including increased LC3-II/I ratio and ATG expression, alongside decreased p62 levels. …”

The Putative C₂H₂ Transcription Factor MtfA Is a Novel Regulator of Secondary Metabolism and Morphogenesis in <i>Aspergillus nidulans</i> by Vellaisamy Ramamoorthy (459033)

“…However, in this case, over-expression of <i>mtfA</i> enhanced the transcription of penicillin genes, increasing penicillin production more than 5 fold with respect to the control. Importantly, in addition to its effect on secondary metabolism, <i>mtfA</i> also affects asexual and sexual development in <i>A. nidulans.…”

Steady-State Spectroscopic Analysis of Proton-Dependent Electron Transfer on Pyrazine-Appended Metal Dithiolenes [Ni(pdt)₂], [Pd(pdt)₂], and [Pt(pdt)<sub>2</s... by Steven R. Kennedy (2920332)

“…For all three complexes, protonation results in severe attenuation of the electronic coupling, as measured by the IVCT band. We find nearly 5-fold decreases in electronic coupling for both Ni and Pt, while, for the Pd complex, the electronic coupling is reduced to the point that the IVCT band is no longer observable. …”

Time to Definitive Health-Related Quality of Life Score Deterioration in Patients with Resectable Metastatic Colorectal Cancer Treated with FOLFOX4 versus Sequential Dose-Dense FOL... by Zeinab Hamidou (563982)

“…The TUDD was defined as the time interval between randomization and the first decrease in HRQoL score ≥ 5-point with no further improvement in HRQoL score ≥ 5 points or any further HRQoL data. …”

Treatment with a TRPV agonist reduces the ability of mf to establish infection in mosquitoes. by Nicolas J. Wheeler (8947214)

“…(B) Replication of blood-feeding experiments with 5 mM and 25 mM showed a significant increase in the proportion of blood-fed mosquitoes when blood was supplemented with 5 or 25 mM NAM. …”

Cisd2KO mice exhibit cardiac electromechanical dysfunctions that are similar to those observed in the naturally aged WT mice. by Chi-Hsiao Yeh (7474556)

“…Mouse number <i>n</i> ≥ 5 for each group. Values for each data point can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000508#pbio.3000508.s001" target="_blank">S1 Data</a>. 3M, 3 months old; 6M, 6 months old; 26M, 26 months old; APC, atrial premature complex; AV, atrioventricular; Cisd2KO, CDGSH iron-sulfur domain-containing protein 2 KO; ECG, electrocardiography; KO, knockout; MRI, magnetic resonance imaging; QTc, corrected QT; VPC, ventricular premature complex; WT, wild type.…”

File S1 - Deficiency of the Transcriptional Repressor B Cell Lymphoma 6 (Bcl6) Is Accompanied by Dysregulated Lipid Metabolism by Christopher R. LaPensee (571785)

“…B – Weights of male Bcl6 KO mice were significantly lower than WT littermates at 3, 4, and 5 weeks of age. Each point represents mean+SE for 4 WT (solid line) and 3 KO (dotted line) male mice. …”

Neuritin restores the reduction in the dendritic spine density and the maturity of individual spines in Tg2576 neurons. by Yoori Choi (611187)

“…Tg2576 neurons revealed a significant decrease particularly in type II spines (mushroom type; mature spines with a large head, >0.6 µm, and a short neck), but yielded a slightly higher density of type I spines (stubby type; less mature spines, relatively small spine head, <0.6 µm, and short neck, <0.3 µm) compared to the other groups. …”