Y-27632 collaborated with BA to attenuate the increase in the integrity and decrease in the permeability of epithelial barrier injury induced by LPS in Caco2 monolayers. by Luqiong Liu (11537092)

Y-27632 synergized with BA to alleviate the decrease in the expression of and abnormal localization of ZO-1 and Occludin in LPS-induced Caco2 cells. by Luqiong Liu (11537092)

Inhibition of the mitochondrial fission decreases mtROS production. by Dong Ma (584680)

Subjects:

NaSal increased the excitability of 5-HTergic neurons, but decreased that of GABAergic neurons in the DRN of the ChR2 transgenic mouse. by Yan Jin (143500)

“…(D) Sample traces (left panel) and group data (right panel, paired Student’s <i>t</i>-test) showing that NaSal suppressed the firing of GABAergic neurons evoked by laser light (1 s, 5.5 mW, 473 nm). (E) Sample recordings from a GABAergic neuron showing that NaSal decreased voltage responses to a series of hyperpolarizing currents (-10 to -60 pA, -10 pA/step, duration: 500 ms). …”

Serotonin (5HT) levels are elevated in <i>Ube3a</i> deficient mice in the striatum and cortex and decreased in paternal 7p duplication animals. by M. Febin Farook (142138)

Ablation of Tph1 gene in dams decreased circulating serotonin and calcium on day 1 and 10 of lactation. by Jimena Laporta (383836)

Hormone therapy decreased β-amyloid load and improved cognitive performance in early middle-aged mice. by Amy Christensen (4062937)

Specificity of ChR2-YFP expression in DRN 5-HT neurons and efficiency of photostimulation <i>in vitro</i>. by Guillaume P. Dugué (620333)

U87MG glioma cells transduced with gal-3 shRNA demonstrate decreased tumor size and growth. by Rafael Yamashita Ikemori (698128)

“…The inoculation of U87MG gal-3 shRNA cells in the flank of nuce mice (n = 5) demonstrated a decrease in tumor size and growth compared to the U87MG scramble shRNA (n = 6). …”

Heterogeneous distribution of 5-HTR subtypes as measured by PET. by Yukiko Hori (299784)

Subjects:

hESCs-CM decreased cancer cells growth. by Shufeng Zhou (398572)

Gene expression of 5-HT transporter (5-HTT), 5-HT_1A receptor (5-HT_1AR) and tryptophan hydroxylase-2 (TPH2) in the raphe. by Thibault Renoir (348572)

“…<p>Measuring mRNA levels of several genes encoding proteins that regulate 5-HT homeostasis, we found significant genotype-sex interactions for both mRNA levels of (A) 5-HTT and (B) TPH2 but not for (C) 5-HT_1AR gene expression. …”

Sildenafil decreases intestinal transit time in a DSS-recovery model of IBS. by Sarah K. Sharman (3966476)

Brain 5-HT. by Caroline Sarah Biskup (163085)

“…<p>Brain 5-HT content in ng/mg tissue in (a) prefrontal cortex (b) frontal cortex and (c) hippocampus. …”

Expression of 5-HT_4(b), 5-HT_2A, 5-HT_2B and 5-HTT mRNA in left ventricular myocardium. by Trond Brattelid (290970)

“…(A) 5-HT_4(b) mRNA levels decreased with foetal and neonatal development and the level in adult myocardium was one tenth of that at day -3 but reappeared in HF; (B) 5-HT_2A mRNA expression increased at birth (day 1), decreased during neonatal development and was unaltered in HF; (C) 5-HT_2B mRNA expression was transiently increased at birth (day 1) compared to adult (day 113) and not changed in HF; (D) 5-HTT mRNA expression was lower in foetal hearts compared to neonatal, adult, Sham and HF which all showed a similar expression level. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Mean Decrease in Margin (MDM) variable importance. by Yuliya V. Karpievitch (259460)

HC-070 decreases anxiety in a standard EPM. by Stefan Just (4811358)

Concentrations of 5-HT and 5-HIAA in brain tissue. by Thibault Renoir (348572)

“…Both 5-HT and 5-HIAA concentrations were decreased in the hippocampus (A/B), the cortex (C/D) and the striatum (E/F) in female HD mice when compared to WT animals. …”