Treatment with the antioxidant <i>N</i>-Acetyl-L-Cysteine (NAC) or with the p53 inhibitor, Pifithrin-α (PFT), prevents ROS formation in hMp84-overexpressing A375 cells. by Daniele Moretti (379766)

Treatment with the antioxidant <i>N</i>-Acetyl-L-Cysteine (NAC) or with the p53 inhibitor, Pifithrin-α (PFT), prevents cell death in hMp84-overexpressing A375 cells. by Daniele Moretti (379766)

Production of O₂^ꜙ, NO and cyclic GMP by 5-HT. by Marie Billaud (261506)

“…<p>A, O₂^░ production was measured by EPR spectrometry in the absence or in the presence of 5-HT 100 µM (black column and white column respectively). …”

Rate-limiting enzymes tyrosine hydroxylase (catecholamines) and tryptophan hydroxylase (5-HT) post-stress. by C. Brad Wilson (468614)

“…<p>Tyrosine hydroxylase elevation in the PFC (A) and hippocampus (B) substantiated the findings of elevated levels of NE and DA, while down-regulated tryptophan hydroxylase in the PFC (C) and hippocampus (D) confirmed decreased levels of 5-HT. …”

5-HT-induced cardiomyocyte injury required the presence GC or NE <i>in vitro</i>. by Wang Xinxing (523139)

“…<b>A.</b> The cell viability of cardiomyocytes treated with 10⁻⁸ M 5-HT and 10⁻⁶ M GC decreased significantly compared with the control. …”

5-HT₇Dro knock-down results are consistent with pharmacological studies. by Jaime Becnel (218896)

“…C) The activity of male flies carrying either the 5-HT₇Dro-GAL4 element (GAL4, white bar), the UAS-sym-p5-HT₇RNAi element (UAS-RNAi, black bar), or both (F1, gray bar) was measured using the DAMS system for five days. …”

Psychological stress in aged female mice causes acute hypophagia independent of central serotonin 2C receptor activation by Chinami Matsumoto (4585549)

“…The administration of a serotonin 2C receptor (5-HT_2CR) antagonist suppressed plasma corticosterone but did not affect the reduction in food intake. …”

Shoot-to-root translocation of GmNN1/FT2a regulates soybean nodulation. by Xinxin Li (281237)

Table_1_Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling.DOCX by Jianxin Li (158332)

“…Background<p>Major depressive disorder (MDD) is a severe mental disorder related to the deficiency of monoamine neurotransmitters, particularly to abnormalities of 5-HT (5-hydroxytryptamine, serotonin) and its receptors. …”

Developmental change in 5-HT_1A binding in known cause of death controls (predischarge and postdischarge combined). by Hannah C. Kinney (10280975)

“…Binding in these nuclei are visually (top row) and quantitatively (bottom row) decreasing with PC age, the latter shown with plots of 5-HT_1A binding vs PC age. …”

Stress responses after knockdown of octopamine receptor OAMB and serotonin receptor 5-HT_1A in IPCs. by Jiangnan Luo (218899)

“…In an earlier study it was shown that 5-HT_1A knockdown decreased starvation resistance <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099732#pone.0099732-Luo1" target="_blank">[22]</a>. …”

5-HT2A and Foxo are required in R2/R4 neurons to mediate the effects of death perception on lifespan. by Christi M. Gendron (14200157)

“…<p>Knock-down of <i>5-HT2A</i> mRNA expression in R2 alone (A), in R4d alone (B), or in R2/R4 inhibited lifespan differences due to death perception. …”

Glial 5-HT_2a receptors are necessary and rate limiting for experience-dependent synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…The Or42a OSN innervation volume with glial <i>5-HT</i>_<i>2A</i><i>R</i> OE is very significantly decreased in comparison to the control EB condition (<i>p</i> = 4.64 × 10⁻¹⁰). …”

Effect of perfusion with VEGF121 on outflow facility. by Tomokazu Fujimoto (709192)

eIF5a is up-regulated in unruptured AAAs and decreased in ruptured AAAs. by Dong Ma (584680)

Subjects:

hESCs-CM decreased cancer cells growth. by Shufeng Zhou (398572)

Data_Sheet_1_5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model.docx by Xujiao Zhou (6661499)

“…In addition, the high expression of GS and EAAT2 induced by glaucoma was downregulated by the 5-HT1A receptor agonist 8-OH-DPAT and the 5-HT1A receptor antagonist WAY-100635, respectively. …”

Decreased number of cilia in partially formed KV lumen. by Jeong-gyun Kim (4330168)

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT_2B) stimulates the apoptosis of activated hepatic stellate cells and inhibits their proliferation while concurrently regressing hepatocyte proliferation. …”

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT_2B) stimulates the apoptosis of activated hepatic stellate cells and inhibits their proliferation while concurrently regressing hepatocyte proliferation. …”