Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image_1_Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression.jpeg by Damariz Marín-Palma (5392466)

“…</p>Results<p>HIV-1-infected individuals showed a significant decrease in HDL levels, particularly those subjects with higher viral load and lower CD4+ T-cell counts. …”

Localisation and quantification of NL2 immunoreactivity within the hippocampus of WT and dystrophin-deficient mice, reacted and imaged under identical conditions. by Elżbieta Krasowska (635317)

“…*<i>P</i><0.05; ANOVA with Tukey’s posthoc test; N = 3 animals. Scale bars (A1, B1, C1) 50 µm; (A2, B2, C2) 10 µm; (A3, B3, C3) 5 µm.…”

Image_1_Ten-Year Legacy Effects of Three Eight-Month Exercise Training Programs on Cardiometabolic Health Parameters.JPEG by Johanna L. Johnson (6591113)

“…Original participation in either the moderate intensity exercise or control group resulted in a 10.5% decrease in peak VO₂ over the ensuing 10 years. …”

Table_1_Keeping an Eye on Wild Brown Trout (Salmo trutta) Populations: Correlation Between Temperature, Environmental Parameters, and Proliferative Kidney Disease.XLSX by Aurélie Rubin (3185349)

“…<p>Proliferative kidney disease (PKD) is an emerging disease of salmonids caused by the myxozoan parasite Tetracapsuloides bryosalmonae, which plays a major role in the decrease of wild brown trout (Salmo trutta) populations in Switzerland. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Localization of anti-TG2 scFvs after intraventricular delivery and footprint analysis. by Sabrina Boscolo (251883)

“…Mice injected with monoclonal antibody class2 showed indistinguishable forelimb and hindlimb stride length from those produced by negative control mice (H) a little decrease in the fore and hind-base width (I) while showed a significant different overlap measurement compared to the negative control mice (J). …”

Table_1_Trends in the Epidemiology of Leishmaniasis in the City of Barcelona (1996–2019).DOC by David Palma (4968895)

“…There was an increase of foreign origin cases, and a decrease in the number of cases associated to any immunosuppression.…”

Only 52 of the 256 possible genotypes between PfCRT^3D7 and the CQ-transporting PfCRT^Dd2 isoform have measured phenotypes. by Zachary R. Sailer (4025459)

“…This trajectory passes through the PfCRT^{China e} and PfCRT^K1 isoforms. Five of the eight steps increase CQ transport activity, two have no effect, and the final step causes a decrease.…”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image 1_Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice.pdf by Yan Gong (103494)

“…Additionally, MA notably inhibited osteoclast activity, as evidenced by a decrease in the number of osteoclasts and a significant suppression of F-actin formation. …”

Defining Hypo-Methylated Regions of Stem Cell-Specific Promoters in Human iPS Cells Derived from Extra-Embryonic Amnions and Lung Fibroblasts by Koichiro Nishino (219736)

“…Thus, a group of genes becomes active through a decrease of methylation in their promoters. …”

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation by Daniela De Stefano (131144)

Supplementary Material for: The 20-year trends in caries and associated determinants among adults in “post-Soviet” Lithuania: repeated cross-sectional studies by Stangvaltaite-Mouhat L. (9382166)

“…The 1997/1998 survey (first survey) recruited a stratified random sample of 570 individuals from 10 selected areas in Lithuania (response rate 52%) and the 2017/2019 survey (second survey) recruited a stratified random sample of 723 individuals from 5 biggest Lithuanian cities and one randomly selected peri-urban/rural area from each of 10 Lithuanian counties (response rate 53%). …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image_1_Addition of Fibroblast-Stromal Cell Markers to Immune Synovium Pathotypes Better Predicts Radiographic Progression at 1 Year in Active Rheumatoid Arthritis.tif by Xue-Pei Zhang (10650773)

“…The primary outcome was radiographic progression defined as a minimum increase of 0.5 units of the modified total Sharp score from baseline to 1 year.…”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image_1_Therapy With Different Dose Regimens of Rituximab in Patients With Active Moderate-To-Severe Graves’ Orbitopathy.tif by Irene Campi (10531166)

“…Primary endpoint was disease inactivation, measured as a decrease of the Clinical Activity Score (CAS) of at least two points. …”

The number of infiltrated ANGPTL2-positive macrophages increases in ischemic brain. by Toshihiro Amadatsu (3352955)

“…After ligation of the right common carotid artery (CCAO), we observed a 40% drop in CBF. MCA occlusion promoted a further decrease to less than 80–90% of baseline CBF. …”

Alterations in tone and FM sweeps evoked activity during repetitive stress. by Ghattas Bisharat (20706928)

“…Activity rates decreased at moderate sound intensities, while activity at high intensities remained comparable to baseline intensities (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003012#pbio.3003012.g002" target="_blank">Fig 2D</a>, 2-way ANOVA, condition F = 16.1, <i>p</i> = 6.02 × 10⁻⁰⁵, nested ANOVA (mouse nested within session) F = 16.1, <i>p</i> = 5.9 × 10⁻⁰⁵, mean ± SE). …”