The Type 2 Diabetes Risk Allele of <i>TMEM154</i>-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes by Marie Neergaard Harder (232759)

“…Significant associations between <i>TMEM154</i>-rs6813195 and the beta cell measures insulinogenic index and disposition index and between <i>FAF1</i>-rs17106184 and 2-hour serum insulin levels were selected for further investigation in additional Danish studies and results were combined in meta-analyses including up to 6,486 Danes.</p><p>Results</p><p>We confirmed associations with type 2 diabetes for five of the seven SNPs (<i>TMEM154</i>-rs6813195, <i>FAF1</i>-rs17106184, <i>POU5F1/TCF19</i>-rs3130501, <i>ARL15</i>-rs702634 and <i>ABCB9/MPHOSPH9</i>-rs4275659). …”

Tunicamycin produces a concentration- and time-dependent decrease in cell viability in SH-SY5Y cells concomitant with caspase-3 activation. by Arindam P. Ghosh (317870)

“…<p>(A) Treatment of SH-SY5Y cells with tunicamycin (0.1–5µM) for 24 h caused a progressive decrease in cell viability as measured by Calcein AM cleavage assay. …”

Production of O₂^ꜙ, NO and cyclic GMP by 5-HT. by Marie Billaud (261506)

“…<p>A, O₂^░ production was measured by EPR spectrometry in the absence or in the presence of 5-HT 100 µM (black column and white column respectively). …”

S1 File - by Yonghui Zhang (279832)

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Detailed information on field experiments. by Yonghui Zhang (279832)

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List of symbols used in this study. by Yonghui Zhang (279832)

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Data sources for calibration and evaluation. by Yonghui Zhang (279832)

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CcnA mutation of Loop A decreases the interaction with the 5′ UTR of P2-<i>ctrA</i> mRNA and 5′ UTR of <i>gcrA</i> mRNA. by Wanassa Beroual (5314028)

Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria by Patricia A. Reis (109310)

5-HT₇Dro knock-down results are consistent with pharmacological studies. by Jaime Becnel (218896)

“…C) The activity of male flies carrying either the 5-HT₇Dro-GAL4 element (GAL4, white bar), the UAS-sym-p5-HT₇RNAi element (UAS-RNAi, black bar), or both (F1, gray bar) was measured using the DAMS system for five days. …”

A Y45F mutation in hepatitis C virus NS4A causes a decrease in infectious viral titer. by Allison E. Roder (6312761)

The novel <i>carboxylesterase 1</i> variant c.662A>G may decrease the bioactivation of oseltamivir in humans by Jaeseong Oh (3947381)

“…A novel <i>CES1</i> c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease CES1 enzymatic activity in an <i>in silico</i> analysis. …”

Decreased pulmonary cell inflammatory response in FI-A2 and G-A2 peptide vaccinated mice after RSV challenge. by Gertrud U. Rey (501694)

Psychological stress in aged female mice causes acute hypophagia independent of central serotonin 2C receptor activation by Chinami Matsumoto (4585549)

“…The administration of a serotonin 2C receptor (5-HT_2CR) antagonist suppressed plasma corticosterone but did not affect the reduction in food intake. …”

<i>btuE</i> expression results in decreased intracellular ROS. by Felipe A. Arenas (23050)

(R)-albuterol decreases cytokine mRNA levels in activated T cells by Marcela A Ferrada (41716)

“…</p><p></p> (R)-albuterol, (S)-albuterol or racemic albuterol (R + S) at a dose (10M) were added to T (EL-4) cells pre-activated with mitogens Concanavalin A (Con A, 5 μg/ml) and phorbol myristate acetate (PMA, 100 ng/ml) (CP). …”

CC-1⁺ immunostained cell numbers decrease by 2 days after TBI and return to control levels by 5 weeks. by Krista A. Dent (709531)

“…Panels show contralateral (Contra) and ipsilateral (Ipsi) external capsule (EC) at (A,B) 2 days (2d), (C,D) 2 weeks (2w) and (E,F) 5 weeks (5w) (G) In the external capsule numbers of CC-1⁺ oligodendrocytes were decreased by 2d after injury, remained decreased at 2 weeks and returned to normal levels by 5 weeks. …”

Levels of the antioxidant enzyme, MnSOD are decreased in the cortical and hippocampal microvessels. by Susan A. Austin (768265)

UGGT activity decreases in <i>uggt-1(RNAi)</i> worms but no decrease was observed in <i>uggt-2 (RNAi)</i> worms. by Lucila I. Buzzi (198284)

LC-IMS-CID-MS CKO vs K5Cre results. by Kevin J. Mills (9270966)

“…<div><p>CCAAT/enhancer binding protein- (C/EBP) is a basic leucine zipper transcription factor that is abundantly expressed in epidermal keratinocytes of skin. …”