Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT_2B) stimulates the apoptosis of activated hepatic stellate cells and inhibits their proliferation while concurrently regressing hepatocyte proliferation. …”

CCN3 protein decreases β-cell proliferation. by Renée Paradis (326111)

<i>Neisseria meningitidis</i> Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation by Joseph Gault (427444)

“…Unlike class I pilins that carry a single glycan, we found that class II pilins display up to 5 glycosylation sites per monomer on the pilus surface. …”

Intracameral injections of ATX inhibitor decreases IOP in rabbits. by Padma Iyer (141117)

“…Drug treated eyes showed a significant decrease in IOP from the baseline (by 6–7 mm Hg) at 24 and 48 hrs based on paired t-test. …”

Decreased cell stiffness after dissociation of intercellular adhesion. by Kristina Seiffert-Sinha (627059)

“…Cell stiffness was measured before and after the nanorobotic surgery and decreases from 30.0±1.5 kPa to 20.5±2.8 kPa, respectively. …”

Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis by Raj Vuppalanchi (458660)

“…In this study, we examined if certain microRNAs (miRNA) are associated with decreased hepatic CYP3A activity in cirrhosis.…”

For most sites, observed abundance decreases with size class. by Sarah L. Becker (6631253)

A. We randomly selected 20 mutually exclusive groups of protein complexes that contained exactly five subunits; we mapped the corresponding gene pairs to SINaTRA scores, and plotte... by Alexandra Jacunski (5665486)

“…A SINaTRA cutoff of 0.95 has approximately half of its pairs associated with the same complex; however, a decrease in the cutoff shifts this balance. …”

Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study by Sérgio Aparecido Cleto (3143949)

“…We previously demonstrated that early initiation of sustained low-efficiency dialysis (SLED) followed by daily SLED significantly decreases mortality. …”

Decreased health-related quality of life in angiodysplasia patients: A cross-sectional cohort by Karina V. Grooteman (4050388)

Deterioration of the anammox process at decreasing temperatures and long SRTs by Maaike Hoekstra (3915545)

Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer by Giorgia Urbinati (554921)

“…Two of the five siRNAs tested were found to efficiently inhibit mRNA of both <i>TMPRSS2-ERG</i> variants and to decrease ERG protein expression. …”

Propagation of an action potential through ephaptic coupling is achieved for a decreased extracellular conductivity. by Karoline Horgmo Jæger (6785450)

Reversion to susceptibility was consistent with decreasing relative <i>vanA</i> copy number. by Samuel E. Blechman (19506884)

A Functional 12T-Insertion Polymorphism in the <i>ATP1A1</i> Promoter Confers Decreased Susceptibility to Hypertension in a Male Sardinian Population by Victoria L. Herrera (383897)

“…To test the effects of decreased α1Na,K-ATPase expression on blood pressure, we measured blood pressure by radiotelemetry in three month-old, highly inbred heterozygous knockout <i>ATP1A1+/−</i> male mice with resultant 58% reduction in ATP1A1 protein levels. …”

Effect of iron mining tailings as a red ceramic additive for decreased sintering temperature by Igor Brumano Coelho Amaral (10472061)

Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein by Jianhua Zhao (531939)

Subjects:

A model on the roles of p33-mediated recruitment of Rab5-positive endosomes in the formation of large tombusviral replication compartments. by Kai Xu (122914)

TGFβ1 expression was increased, and RASAL1 expression was decreased in NTM cells in response to a hypoxic environment. by Fiona McDonnell (2636635)

“…A 0hr Control was set to 100%, and the normoxic and hypoxic results were presented as a percentage of this; Normoxic = 95.5%, Hypoxic = 159.4% (P<0.01). n = 3 *P<0.05, **P<0.01. …”

Glia-targeted 5-HT_2A receptor expression in adults reopens experience-dependent synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…There is a significant decrease in the Or42a OSN innervation volume with glial-targeted <i>Gal80</i>^<i>ts</i><i>-5-HT</i>_<i>2A</i><i>R</i> OE at 28°C (<i>n</i> = 20/condition, <i>p</i> = 1.00 × 10⁻¹⁵). …”