SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress by Mengli Zhang (6331172)

“…As a result, SIRT5 deficiency decreases mitochondrial ATP production, increases AMP/ATP ratio, and subsequently activates AMP-activated protein kinase (AMPK) in cultured cells and mouse hearts under energy stress conditions. …”

Raw data 1–5. by Fateme Khorramroo (18086501)

Panel (a) shows ensemble mean global mean near-surface air temperature in historical and RCP simulations from CanESM2 by Nathan P Gillett (557010)

“…Shaded bands show estimates of the 5–95% uncertainty ranges in the ensemble mean ratios, derived by taking the standard deviation of the ratio from each of the five independent pairs of simulations with and without aerosol changes, dividing by the square root of five (the ensemble size), and multiplying by a Student-<em>t</em> statistic with a cutoff value of 0.05 and four degrees of freedom (one less than the ensemble size). …”

Selective downregulation of SR Ca²⁺ handling proteins and decreased SR Ca²⁺ uptake in TG mice hearts. by Mayilvahanan Shanmugam (691549)

“…For each atrial Ca²⁺ uptake experiment, atria from four mice were pooled. n = 4 for each group. The V_max of Ca²⁺ uptake was obtained at pCa 5.5.…”

Ratanasampil is more effective than flunarizine in relieving migraine by Aiqin Zhu (11580439)

“…The serum levels of biomarkers, including 5-HT, BDNF, NGF and β-EP, significantly elevated after eight weeks of treatment with RNSP, whereas the level of CGRP significantly decreased. …”

Decreased hypotaurine levels within cells lacking the ADO gene in U251 cells. by Hong Tian (169626)

Changes after 45 minutes in the proportion of LTP, LTD or no plasticity responses observed in L5PyNs population induced by the HFS protocol in the presence of D1R agonist or antago... by Claire Nicole Jeanne Meunier (703124)

“…<p>(A and D) Percentages of L5PyNs displaying LTP, LTD or no plasticity in 129/Sv mice and 5-HT_1AR-KO mice in control conditions. …”

Propensity-score matched open aortic group. by Tomi Obafemi (12328433)

“…Patients who underwent open aortic procedures experienced an improvement in 30-day mortality (7% to 3.5%, p = 0.012), decrease in median ICU LOS (91.7 hours to 69.6 hours, p<0.001), and a decrease in duration of mechanical ventilation (79.3 hours to 46.3 hours, p = 0.003). …”

Pre-match open aortic group. by Tomi Obafemi (12328433)

“…Patients who underwent open aortic procedures experienced an improvement in 30-day mortality (7% to 3.5%, p = 0.012), decrease in median ICU LOS (91.7 hours to 69.6 hours, p<0.001), and a decrease in duration of mechanical ventilation (79.3 hours to 46.3 hours, p = 0.003). …”

Pre-match CABG/Valve group. by Tomi Obafemi (12328433)

“…Patients who underwent open aortic procedures experienced an improvement in 30-day mortality (7% to 3.5%, p = 0.012), decrease in median ICU LOS (91.7 hours to 69.6 hours, p<0.001), and a decrease in duration of mechanical ventilation (79.3 hours to 46.3 hours, p = 0.003). …”

Propensity-score matched CABG/Valve group. by Tomi Obafemi (12328433)

“…Patients who underwent open aortic procedures experienced an improvement in 30-day mortality (7% to 3.5%, p = 0.012), decrease in median ICU LOS (91.7 hours to 69.6 hours, p<0.001), and a decrease in duration of mechanical ventilation (79.3 hours to 46.3 hours, p = 0.003). …”

Rac and PKB activities are required for a late phase of cerebellar LTP. by Claire Jackson (362873)

“…<p><b>A</b>) Addition of the Rac inhibitor EHT1864 (50 µM; n = 7) to pipette solution decreases LTP duration. …”

Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage by Lucia Reh (546554)

“…To enable this, properties that render HIV-1 envelopes (Env) capable of eliciting bnAb responses need to be defined. Here, we followed the evolution of the V2 apex directed bnAb lineage VRC26 in the HIV-1 subtype C superinfected donor CAP256 to investigate the phenotypic changes of the virus populations circulating before and during the early phases of bnAb induction. …”

Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients by Bai-Wei Gu (740949)

“…Here we describe the production of iPS cells from DC patients with <i>DKC1 </i>mutations <i>Q31E</i>, <i>A353V </i>and <i>ΔL37</i>. …”

Kcnk5b requires CaMKK for growth and SHH/<i>shha</i> expression. by Xiaowen Jiang (8291814)

Patients’ histories are presented in decreasing length of observation and colour coded as red for the days of use or referred use and green for abstinence days. by Francesco Lolli (2530471)

<i>MMP-1</i> OE restores <i>5HT</i>_<i>2A</i><i>R</i>-deficient experience-dependent pruning. by Vanessa Kay Miller (19775496)

“…<p><b>A</b>, Or42a OSN innervation of VM7 glomeruli shown as a color-coded Z-stack (scale, top right) with 24-hour exposure from 0 to 1 dpe to the mineral oil vehicle control (<u>left</u>) and EB odorant (<u>right</u>) in astrocyte-like glia control (<u>top</u>: <i>w</i>^<i>1118</i>;<i> Or42a-mCD8::GFP/+; GMR86E01-Gal4/+</i>), the astrocyte-like glia <i>5-HT</i>_<i>2A</i><i>R</i> RNAi alone (<u>middle</u>: <i>w</i>^<i>1118</i>;<i>Or42a-mCD8::GFP/+; GMR86E01-Gal4/UAS-5-HT</i>_<i>2A</i><i>R RNAi</i>), and with <i>MMP-1</i> overexpression (<u>bottom</u>: <i>w</i>^<i>1118</i>;<i>Or42a-mCD8::GFP/UAS-MMP1; GMR86E01-Gal4/UAS-5-HT</i>_<i>2A</i><i>R RNAi</i>). …”

NR4A1 expression does not decrease after inhibition of p38, JNK and Src pathways. by Glenda Eger (636934)

Five homogeneous climate zones of Pakistan. by Firdos Khan (10987974)

Cell viability of U-87 MG cell cultures treated with Ser/5-HT or fluoxetine. by Glaucia Vilar-Pereira (686134)