Showing 901 - 920 results of 99,883 for search '(( 5 ((ht decrease) OR (we decrease)) ) OR ( 5 ((a decrease) OR (nn decrease)) ))', query time: 1.36s Refine Results
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    Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

    Published 2021
    “…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”
  17. 917

    Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

    Published 2021
    “…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”
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    Performance in the full reversal, perseverance and learned non-reward tests in the SB242084 (a–b) and 5-HT<sub>2C</sub>R KO experiments (c–d). by Simon R. O. Nilsson (477987)

    Published 2013
    “…(b) Significant main effects of test condition (F<sub>2, 61</sub> = 9.65, p<.0001) and drug × test interactions (F<sub>2, 61</sub> = 3.46, p = .037) on incorrect responses to criterion. SB242084 decreased incorrect responses to criterion in the perseverance test (F<sub>1,20</sub> = 5.96, p = .024). …”
  20. 920

    Image_5_GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis.png by Jan Nagenborg (14771194)

    Published 2023
    “…</p>Methods and results<p>Here, we demonstrate reciprocal expression regulation of STAT5A and STAT5B in human atherosclerotic lesions. …”