Estimating the NIH Efficient Frontier by Dimitrios Bisias (167004)

“…</p> <h3>Conclusions</h3><p>Our analysis is intended to serve as a proof-of-concept and starting point for applying quantitative methods to allocating biomedical research funding that are objective, systematic, transparent, repeatable, and expressly designed to reduce the burden of disease. …”

Image1_Lavandula viridis L´Hér. Essential Oil Inhibits the Inflammatory Response in Macrophages Through Blockade of NF-KB Signaling Cascade.jpg by Monica Zuzarte (11995493)

“…From a pharmacological point of view, the essential oil showed a potent antioxidant effect and inhibited nitric oxide production through down-modulation of nuclear factor kappa B-dependent Nos2 transcription and consequently iNOS protein expression as well as a decrease in proteasomal activity. …”

Early life malaria exposure and academic performance by Ninja Ritter Klejnstrup (5439704)

“…In addition, we use sibling variation in birth-year exposure to malaria to strengthen our identification. A ten percentage-point decrease in malaria prevalence in birth year is associated with a 0.06 standard deviation (p = 0.000) increase in English literacy achievement. …”

Datasheet1_Low total cholesterol predicts early death in children with hemophagocytic lymphohistiocytosis.zip by Li Xiao (307908)

“…TC ≤ 3.11 mmol/L and BUN ≥ 7.14 mmol/L were the independent risk factors for 30-day mortality [HR(95%CI): 2.85(1.46, 5.57) and 2.90(1.48, 5.68), respectively]. The presence of one of these risk factors increased the 30-day mortality rate by 6-fold [HR = 6.24, 95%CI: (3.18, 12.22)] and the presence of two risk factors by nearly 10-fold [HR = 9.98, 95%CI: (4.23, 23.56)] compared with the patients with no risk factors.…”

Table1_Low total cholesterol predicts early death in children with hemophagocytic lymphohistiocytosis.xlsx by Li Xiao (307908)

“…TC ≤ 3.11 mmol/L and BUN ≥ 7.14 mmol/L were the independent risk factors for 30-day mortality [HR(95%CI): 2.85(1.46, 5.57) and 2.90(1.48, 5.68), respectively]. The presence of one of these risk factors increased the 30-day mortality rate by 6-fold [HR = 6.24, 95%CI: (3.18, 12.22)] and the presence of two risk factors by nearly 10-fold [HR = 9.98, 95%CI: (4.23, 23.56)] compared with the patients with no risk factors.…”

Image_1_Quantitative late gadolinium enhancement cardiac magnetic resonance analysis of the relationship between ablation parameter and left atrial tissue lesion following pulmonar... by Qian Wang (32718)

“…A tissue lesion point was defined when the LGE-CMR IIR was > 1.2.…”

Increase of MLF knock down efficiency during vegetative growth using strategy 2 compared to strategy 1. by Zi-Qi Lin (6444350)

“…The ratio of each target protein over the loading control RAN is calculated. Fold change is calculated as the ratio of the difference between MLFkoSC cell line and the MLFko cell line, to which a value of 1 was assigned. …”

(CASE 1) quantitative development of model properties with time. by Xiao Fu (74654)

“…<p>(A) Average oxygen tension decreased with increasing occlusion events despite occasional small increases, and had an overwhelming drop near the end of simulation. …”

Inhibition of CSF1R, IL-8, and IL-34 reduces T cell anergy in PortalBMC <i>ex vivo</i> cultures. by Juan Pablo Arnoletti (12275290)

“…After incubation, cells were collected and analyzed for identification of T cell subpopulations by flow cytometry and culture supernatant conditioned media were analyzed in duplicate by ELISA for comparison of IFNγ levels relative to untreated PortalBMC cultures. (<b>A</b>) Though the limited sample number precluded analysis of statistical significance, a strong trend for decreasing T cell anergy with antibody treatments was seen. …”

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca²⁺ Release via ROS-Stimulated Ryanodine Receptors by Paola Llanos (750250)

“…Inhibitory ryanodine significantly decreased H₂O₂-stimulated insulin secretion and prevented the 4.5-fold increase of cytoplasmic [Ca²⁺] produced by incubation of dissociated β-cells with H₂O₂. …”

Spatial regulation of platelet spreading. by Ashley Kita (200234)

“…On stripes of protein thinner than 5–6 µm, only a fraction of a platelet's final spread area is on protein. …”

Comparison of root growth and development of Col seedlings grown in different concentrations of glucose containing medium. by Bhuwaneshwar S. Mishra (267264)

“…<p>(A) Root growth, lateral roots, seedling morphology and root hair formation of 5 d old Col seedlings transferred to increasing concentrations of glucose containing medium for 2–5 days. …”

<i>Hdac3</i> genetic reduction does not reverse transcriptional dysregulation in R6/2. by Lara Moumné (139215)

“…With the exception of a slight decrease in <i>Bdnf</i> V, <i>Hdac3</i> reduction did not affect <i>Bdnf</i> expression. …”

Geographic distribution of random forest model predictions of Spotted and Eastern towhee species identity. by Ximena León Du’Mottuchi (21560805)

“…<b>(A)</b> We trained a model on song data from the entire geographic range of both species (N_{Spotted_towhee} = 796; N_{Eastern_towhee} = 796) and tested how well it predicted the species identification of a subset of all song samples (N_test = 697; accuracy = 89.5%). …”

Reduced Dopamine Release in the Striatum of <i>DAT-Ret^lx/lx</i> Mice by Edgar R Kramer (274117)

“…There is a further significant decrease in the homozygous <i>DAT-Ret^lx/lx</i> mice due to the lack of Ret (<i>n</i> = 5 per genotype, <i>p</i> < 0.05, Student <i>t</i>-test). *, <i>p</i> < 0.05; **, <i>p</i> < 0.01 (Student <i>t</i>-test). …”

Image_4_Effects of high night temperature on soybean yield and compositions.jpeg by Lin Yang (45852)

“…Which could be another important reason for the decrease of sucrose. These findings provided a theoretical basis for enhancing the tolerance of soybean to high night temperature.…”

table_1_In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice.DOCX by Miski Aghnia Khairinisa (5213834)

“…The decrease in maternal behavior was significantly correlated with a decrease in cognition. …”

CXCL12-induced migration via AKT is reduced by LPS treatment. by Hyo-Kyung Pak (727742)

“…<p>A) RPMI 8226 cells were stimulated with 100 ng/mL CXCL12 for 5 minutes in the presence or absence of 10 ng/mL LPS. …”

EFFECT OF WATER DEFICIT AND ABSCISIC ACID ON PHOTOSYNTHETIC AND ANTIOXIDANT METABOLISM IN SEEDLINGS OF Calophyllum brasiliense (CAMBESS.) by Lucas Coutinho Reis (6511265)

“…The decrease in stomatal conductance was accompanied by a decrease in photosynthetic and transpiration rates, but seedlings treated with 10 µM ABA presented a higher photosynthetic rate than the remaining treatments under water deficit. …”

Do Irrigation Solutions Influence the Bond Interface Between Glass Fiber Posts and Dentin? by Thaís Yumi Umeda Suzuki (6572753)

“…Ninety single-rooted human teeth were submitted to endodontic treatment and divided into five groups, according to irrigation solutions: distilled water, 5.25% NaOCl, 25% polyacrylic acid, 2% chlorhexidine, and 23 ppm Ag NP dispersion. …”