Fiber type distribution of <i>m. soleus</i> of NT-1654 and vehicle treated SARCO mice. by Stefan Hettwer (521413)

“…Type I fibers are significantly decreased. The total fiber number in SARCO mice is also significantly decreased compared to treated animals. …”

HMGB1 assay in serums from patients. by Claire Gaillard (357456)

“…<p>(A) without PCA treatment, or (B) after sample purification by PCA treatment. …”

PDGF-BB-induced changes in CCSMC phenotypes. by Jun-Feng Yan (3801184)

“…<p>(A) Microscopic imaging of CCSMCs exposed to 0, 5, 10, or 20 ng/ml PDGF-BB. …”

MC-12 ameliorates colitis induced by both DSS and TNBS. by Nengtai Ouyang (148972)

“…<b><i>B:</i></b> Severe inflammation including infiltration by inflammatory cells, edema, loss of crypts and ulcerations are seen in a DSS + vehicle-treated mouse. <b><i>C, D:</i></b> MC-12, 5 or 25 mg/kg, IP, significantly decreased DSS-induced colonic inflammation. …”

The effect of the PI3K inhibitor LY294002 (LY) on the cell viability and the [Ca²⁺]_i of primary cultured SD rat retinal cells in H₂O₂ in... by Yan Feng (128912)

“…<p>A: Western blot results of the activation of the PI3K/Akt pathway after βE2 treatment for 0.5 hrs; B: Quantitative data of A; C, E, G, and I: Cell viability quantitative data; D, F, H, and J: [Ca²⁺]_i quantitative data; C and D: The effects of LY treatments for 24 hrs and 0.5 hrs on the cell viability and the resting [Ca²⁺]_i; E and F: The inhibitory effect of LY pretreatment for 0.5 hrs on the increased cell viability and [Ca²⁺]_i induced by 10 μM βE2 treatment for 0.5 hrs (10 μM LY in E, 10 μM and 20 μM LY in F); G and H: The effect of LY pretreatment for 0.5 hrs on the decreased cell viability and increased [Ca²⁺]_i induced by 100 μM H₂O₂ treatment for 2 hrs (10 μM LY in G, 10 μM and 20 μM LY in H); I and J: The dose-dependent attenuating impact of 20-50 μM LY pretreatment for 0.5 hrs on the βE2 retinal protective role against H₂O₂ injury, which is associated with the dose-dependent attenuation of the increased [Ca²⁺]_i (Protocol of drug application: LY for 0.5 hrs, E2 for 0.5 hrs and H₂O₂ for 2 hrs). …”

Loss of developmental transcription factors in clear cell renal cell carcinoma. by Han W. Tun (248781)

“…<p><b>a.</b> A microarray heatmap showing significant downregulation of four developmental transcriptional factors in ccRCC and a table showing fold changes of DTFs and their known renal developmental function. …”

Effects of aging and exposure to high-fat diet on spatial strategy use in the Barnes maze. by James P. Kesby (811190)

“…<p>Spatial (<b>A,D,G</b>), serial (<b>B,E,H</b>) and mixed/random (<b>C,F,I</b>) strategy use by adult and aged mice on control diet (CD) and high-fat diet (HFD) on the Barnes maze acquisition days (a1-a5), retention day (Ret) and reversal learning days (Rv1-Rv2). …”

CO suppression of LPS-induced IL-1β transcription, mRNA expression, and protein production. by Maneesha Chhikara (256460)

“…<p>(A) Nuclear run-on assays in THP-1 cells (2×10⁷) showed that CO represses IL-1β transcription by almost 98% within 30 min of LPS stimulation (p = 0.001) and the effect decreased to 67% at 60 min (p = 0.01). …”

DHA treatment and genotype modulate active properties of EC deep layer neurons. by Dany Arsenault (229311)

“…<p>(A, B) Examples of recording trace showing voltage response to a 3-s depolarizing current at the excitation threshold (top trace) and 80±5 pA above the rheobase (bottom trace) from the same neuron of each group. …”

Classification accuracy under fixed iterations. by Alexander Tscshantz (16734185)

“…Plotted are mean accuracies over 5 random network initializations. …”

<i>LGG</i> protects against intestinal injury induced by PAF and LPS. by Julie Mirpuri (109883)

“…PAF/LPS-treated mice that were pre-treated with <i>LGG</i> had lower intestinal injury scores than those pre-treated with vehicle alone (A), representative images are shown. Inflammatory cytokines MIP-2 and TNF-α were also measured by qRT-PCR after PAF/LPS and found to be decreased in the mice pre-treated with <i>LGG</i> (B). …”

Effects of vaccination on HSA during dose reduction and reinstatement. by Michael D. Raleigh (678771)

“…<p>Median total heroin infusions in rats that acquired HSA and completed the dose-reduction protocol (left panel). Rats were trained at a heroin unit dose of 0.06 mg/kg/inf. The heroin dose was sequentially decreased every 5 days to 0.03, 0.01, 0.003 and 0 mg/kg to obtain a dose-response curve. …”

Applied anatomy of round window and adjacent structures of tympanum related to cochlear implantation by Shraddha Jain (12814967)

“…Maximum height of the round window in our study ranged from 0.51-1.27 mm (mean of 0.69 ± 0.25 mm). Maximum width of round window ranged from 0.51 to 2.04 mm (mean of 1.16 ± 0.47 mm). …”

Impact of Transcatheter Aortic Valve Implantation on Kidney Function by Rita Calça (7888694)

“…<div><p>Abstract Background: Chronic kidney disease (CKD) is frequently present in patients with aortic valve disease. Decreased kidney perfusion as a consequence of reduced cardiac output may contribute to renal dysfunction in this setting. …”

Impact of Transcatheter Aortic Valve Implantation on Kidney Function by Rita Calça (7888694)

“…<div><p>Abstract Background: Chronic kidney disease (CKD) is frequently present in patients with aortic valve disease. Decreased kidney perfusion as a consequence of reduced cardiac output may contribute to renal dysfunction in this setting. …”

Data_Sheet_1_Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific.PDF by Cheryl Dykstra-Aiello (9410402)

“…At gene level, few were differentially expressed: ALDH2, ALOX5AP, F13A1, and IMPA2 (males, all stroke); ITGB3 (females, cardioembolic); ADD1 (males, atherosclerotic); F13A1, IMPA2 (males, lacunar); and WNK1 (females, lacunar). …”

Paclitaxel inhibits proliferation, induces EMT, and up-regulates miR-375 expression simultaneously in cervical cancer cells. by Yuanming Shen (645855)

“…The representative cells with morphological changes were labeled (<b>b</b>) Immunoblotting measured the expression of Ecadherin and other EMT related proteins (vimentin, Ncadherin, and fibronectin) in cervical cancer cells (SiHa and CaSki) under different amounts (0, 5, 10, 20 nM) of paclitaxel treatment. The expression of Ecadherin protein was decreased and the expressions of vimentin, Ncadherin, and fibronectin protein were increased in cells treated with paclitaxel for 72 hours in a dose-responsive manner. …”

RIPK3 overexpression inhibits tumor growth. by Yang Xu (178421)

“…(C) KYSE410-vec and RIPK3-D8 clone cells were treated with 10 µM cisplatin combined with a caspase inhibitor, z-LEHD (5 µM) or z-DEVD (5 µM), for 24 h. …”

RIPK3 overexpression inhibits tumor growth. by Yang Xu (178421)

“…(C) KYSE410-vec and RIPK3-D8 clone cells were treated with 10 µM cisplatin combined with a caspase inhibitor, z-LEHD (5 µM) or z-DEVD (5 µM), for 24 h. …”

Acute PDE4B inhibition attenuated spatial memory deficits in the water maze task at 3 weeks post-TBI. by Nicole M. Wilson (4037063)

“…<b>(C)</b> During the probe trial, the percentage of time spent in the target quadrant (TQ) was significantly decreased in the vehicle-treated TBI animals as compared to sham and A33-treated TBI animals. …”