ROP18 directly phosphorylates Irga6 at T102 and T108 in vitro. by Tobias Steinfeldt (154465)

“…<p>(A) Bacterially expressed, purified wt or T102A and T108A mutant Irga6 proteins (300 ng) were coincubated with bacterially expressed, purified GST-ROP18-Ty (10 µl, 5 µl, 1.7 µl respectively; 1 µl ∼20 ng) in the presence of γ³²P-ATP in vitro. …”

Redox Active Cage for the Electrochemical Sensing of Anions by Valeria Amendola (1966936)

“…Such a behavior parallels the gradual decrease of the equilibrium constant for anion inclusion into the [Co^II(<b>1</b>)]⁵⁺ receptor.…”

The TYDQYI-motif in the SBD of PauR is essential for the overall functionality of the receptor and DAR-sensing. by Sophie Brameyer (731567)

“…<p>The most drastic effects on DAR-sensing were gained with the replacement of S38A, T62A, Y66A, D75A and D75N in the SBD of PauR and a decreased effect on DAR-sensing were gained with the replacement of Y90C and I113S in PauR (lower right quadrant). …”

The effects of Hb binding site number and strength on noise. by David M. Holloway (95831)

“…(C) Simulation with 6 Bcd sites and 2 Hb sites, compare to (D) lacZ in a pThb5 embryo (promoter indicated by green arrows in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1001069#pcbi-1001069-g002" target="_blank">Figure 2A</a>). …”

Computational analysis distinguishes BMP-FGF cross inhibition models. by Shyam Srinivasan (522850)

“…(<b>B</b>) Changes in three BMP target (B_T) response properties (maximum levels, EC₅₀, and nH) upon FGF addition under different linearity contexts (in red: 1, all links linear; 2, BMP core pathway nonlinear; 3, inhibitory links nonlinear; 4, all links nonlinear). Each point represents the relative change upon FGF addition for a specific parameter set, and each graph represents 2000 simulations, or 500 per context. …”

Ezh2 SET domain depletion caused blockade of the cellular differentiation in embryonic liver. by Hiroyuki Koike (158631)

“…<p>A: Western blot analysis for Albumin (hepatocyte marker) in the CD45⁻ TER119⁻ non-hematopoietic liver cells from control (Rosa26::CreER(T2)^−/−;Ezh2^F/F mouse) and Ezh2 KO (Ezh2 SET domain depleted mouse; Rosa26::CreER(T2)^+/−;Ezh2^F/F mouse) at ED 18.5 after 3 days TAM injection (TAM; ED 10.5–12.5). …”

Salinomycin inhibits HepG2 and Huh7 autophagic flux. by Johannes Klose (562050)

“…<p>HepG2 and Huh7 cells were exposed to different concentrations of Salinomycin (0.5, 2 and 8 µM) for different time points and analyzed for activity of autophagy. …”

Example of staircases leading to threshold calculation. by Paulo Roney Kilpp Goulart (404481)

“…Each point represents the distance, in u′v′ units, between the chromaticity points that define the target and background. …”

Misclassification rate versus number of impurities and amount of training data. by Viswanadham Sridhara (673863)

“…<p>For joint prediction, each data point corresponds to training/testing a new regression model. …”

The multimerization of <i>D4Z4</i> abrogates CTCF binding and insulation activity. by Alexandre Ottaviani (249884)

“…Input DNA and DNA fraction immunoprecipitated with antibodies to CTCF were amplified by a real-time Q-PCR method (<i>x</i>-axis) using primers encompassing the 5′ CTCF site. …”

Image_1_Clinically important change on the Unified Dyskinesia Rating Scale among patients with Parkinson's disease experiencing dyskinesia.jpg by Rajesh Pahwa (6816655)

“…UDysRS reduction of ≥9 points corresponded to decreased ON time with troublesome dyskinesia of ≥0.5 h per patient diaries, and UDysRS reduction of ≥10 points corresponded to at least minimal improvement on the CGI-C.…”

Image analyses of heterodimerization between TASK1 and TALK2. by Yoshiaki Suzuki (7037)

“…<b>(B)</b> FRET analysis based on acceptor photobleaching was carried out using a confocal microscope. YFP within the ROI 1–5 (white rectangles in the figures) in HEK293 cells co-expressing TASK1-YFP+CFP-TALK2 was selectively photobleached using a laser at 514 nm wavelength. …”

Table_1_Bioinformatics Analysis Identifies Potential Ferroptosis Key Genes in the Pathogenesis of Intracerebral Hemorrhage.DOCX by Tongye Liu (10931763)

“…Treadmill training increased the expression of anti-inflammatory molecules TNFAIP3 and SLC2A1 and reduced the expression of MAPK1, ATF4, and MAPK8, indicating that treadmill training may be utilized as antioxidant therapy to decrease neuronal ferroptosis. …”

Table_1_Bioinformatics Analysis Identifies Potential Ferroptosis Key Genes in the Pathogenesis of Intracerebral Hemorrhage.DOCX by Tongye Liu (10931763)

“…Treadmill training increased the expression of anti-inflammatory molecules TNFAIP3 and SLC2A1 and reduced the expression of MAPK1, ATF4, and MAPK8, indicating that treadmill training may be utilized as antioxidant therapy to decrease neuronal ferroptosis. …”

AMPK activators reduce DVL3 in cervical cancer cells. by H. T. Kwan (291038)

“…(C) Upon treatment with A23187 at different doses (0, 1.25 and 2.5 μM) for twenty hours, C33A and SiHa cells showed 80–90% reduction of DVL3 expression in a dose-dependent manner. …”

National Land Cover Database (NLCD) Tree Canopy Cover (TCC) Hawaii by U.S. Forest Service (17476914)

“…For each year following 2011, on a pixel-wise basis TCC values are updated to a new baseline value if an increase or decrease of 10 percent TCC occurs relative to the 2008-2010 TCC baseline value. …”

Supplementary Material for: Interdigitation and Ellipsoid Zones Disruption Correlate with Visual Outcomes among Treatment-Naive Patients with Diabetic Macular Edema by Sharef N. (10349900)

“…Patients underwent 3.9 ± 2.9 anti-VEGF injections for a mean of 9.1 ± 4.8 months. Following treatment, the mean Snellen visual acuity (VA) improved from 20/52 to 20/44 (<i>p</i> = 0.05), CMT decreased from 432.5 ± 141.4 μm to 375.2 ± 121.4 µm (<i>p</i> = 0.05) and IZ/EZ defect size decreased from 259.83 ± 375.94 µm to 65.34 ± 143.97 µm (<i>p</i> = 0.001). …”

Abiotic stress responses are affected in <i>crk</i> mutants. by Gildas Bourdais (502310)

“…Color intensity is proportional to a Benjamini-Hochberg false discovery rate (FDR) adjusted Z statistic, which takes the estimated means and their variation into account. …”

Heat stress impairs proprioception but not running mechanics by Mtibaa K.

“…Step frequency decreased (−2.5 ± 3.6%) and step length increased (+2.6 ± 3.8%) over time (p < 0.05), independently of condition. …”
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Data_Sheet_1_Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic G... by Lucie Vivancos Stalin (6591539)

“…First, ALK-F1174L mediated an embryonic lethality at mid-gestation and an enlargement of SG with a disorganized architecture in Sox10-Cre;LSL-ALK-F1174L embryos at E10.5 and E11.5. …”