Modeling the RA Morphogen Gradient by Richard J White (82003)

“…Values of parameters that differed between panels were β = 1 ([A–E] and solid curve in [G]) or 0.5 ([F], [H], and dashed curve in [G]); <i>x</i>_f = 400 μm ([A–C] and [F–H]) or 450 μm (D–E); <i>f</i>₀ = 0 (B), 400 ([A], [C], [F–H], and solid curves in [D] and [E]), or 1,100 (dashed curves in [D] and [E]); <i>k</i>_deg = 500 sec⁻¹ ([A] and [C–G]) or 0.03 sec⁻¹ (B); <i>k</i>_max = 0.001 ([A] and [C–G]) or 4 (B); <i>V</i>(<i>x</i>) = 5 for <i>x</i> > <i>x</i>_f – 40, zero otherwise ([A], [D], [E], and solid curves in [B], [C], and [G]), 2.5 for <i>x</i> > <i>x</i>_f – 40, zero otherwise (dashed curves in [B] and [C]), 0.2 for all <i>x</i> ([F], dashed curve in [G], and solid curve in [H]), or 0.1 for all <i>x</i> (dashed curve in [H]).…”

Diversity of mutational paths in the primary/promiscuous activity space. by Hector Garcia-Seisdedos (158269)

“…Mutational paths (red lines) connecting a starting variant (red data point) and a final variant (blue data point) are shown. …”

<i>ELMO1</i> promotes cell migration and invasion by RA FLS. by John W. Whitaker (728679)

“…<p>(<b>A</b>) Cell migration in the wound closure assay shows that <i>ELMO1</i> knockdown with siRNA decreases cell migration whereas the control or ELMO2 siRNAs do not. …”

Change of signaling molecules, proliferation, apoptosis, invasion ability and MMP-2 expression in 786-0 cells with knockdown EpoR. by Pengjie Wu (307334)

“…In 786-0 cells expressing EpoR siRNA, EpoR and p-EpoR decreased by >90%, p-STAT5 decreased by >60%, but p-Erk1/2 increased by >36%, as compared with those in the two controls. …”

Gangliosides are required for viral capture mediated by mDC. by Nuria Izquierdo-Useros (91232)

“…Data show mean values and standard error of the mean (SEM) from five independent experiments including cells from at least six donors. mDCs capture significantly higher amounts of GM3-containing LUV_HIV-tRed than Cer or Ø LUV_HIV-tRed (<i>p</i><0.0001, paired <i>t</i> test). mDCs capture significantly higher amounts of GM1a-containing LUV_HIV-tRed than negatively charged PS-LUV_HIV-tRed (<i>p</i> = 0.0081, paired <i>t</i> test). …”

Quantitative analysis <i>in vivo</i> MRI scans. by Lucas W. E. Starmans (379995)

“…<p><i>In vivo</i> T₂ of the thrombus pre- and post-injection with FibPep-ION-Micelles (n = 5) and NCFibPep-ION-Micelles (n = 4). The horizontal lines represent the group means and the average mean for the two groups combined (n = 9). …”

Pupil dilation and microsaccades provide complementary insights into the dynamics of arousal and instantaneous attention during effortful listening by Maria Chait (6765644)

“…Initial steps were of 12dB SNR, and decreased steadily following each reversal (8dB, then 5dB) up to a minimum step size of 2dB. …”

HepR21 cells have increased resilience to nutrient deprivation compared to HepG2 cells. by Paramita Saha (473954)

“…A set of cells were kept as control. The survivability of HepR21 cells was found to remain unaffected while HepG2 cells were highly sensitive upon prolonged starvation with an overall 50% decrease in growth after 36 h of starvation. …”

DataSheet_1_Treatment With Lipopolysaccharide Induces Distinct Changes in Metabolite Profile and Body Weight in 129Sv and Bl6 Mouse Strains.docx by Maria Piirsalu (8627697)

“…According to the general linear model analysis (GLM), the 1.5 h LPS challenge in Bl6 caused a decrease of propionylcarnitine (C3), glucogenic amino acids, and acetylornithine (Ac-Orn), whereas the response of 129Sv included decreased concentrations of short-chain acylcarnitines (SCACs), citrulline, and elevation of glycerophospholipid (PCaa C42:0) and sphingolipid [SM(OH)C16:1]. 24 h after LPS administration, robust alterations in lipid profile were observed in both strains. …”

Comparison of the rescue ability of Gas7 wild-type and mutant protein. by Bo-Tsang Huang (162584)

“…Data points represent mean ± SEM, ***<i>P</i><0.001. (L–S) Representative images of cortical neurons with shGas7GFP and Gas7WT^ShR-myc co-transfection (L–O) or shGas7GFP and Gas7MT^ShR-myc co-transfection (P–S). …”

Shed GP induces secretion of cytokines from DCs and MØ. by Beatriz Escudero-Pérez (663743)

“…<p>(<b>A</b>) 5×10⁵ of DCs (in white) and MØ (in gray) were incubated for 24 h with concentrated culture supernatants as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004509#ppat-1004509-g002" target="_blank">Figure 2</a>. …”

Statistical results from mixed-effects ANOVAs for all metabolic and hormonal variables. by Amy C. Reynolds (314616)

“…A trend for decreasing testosterone was found. …”

Choosing the best heuristic for seeded alignment of DNA sequences-3 by Yanni Sun (27928)

“…Each point represents a locally optimal set of seeds. …”

Effect of MDMA and HT on the scotopic OPs at 3 h and 24 h. by João Martins (5652628)

“…(A₂) Time to peak values showed the same behavior for all OPs, in which both MDMA and HT groups presented decreased time to peak values at 3 h time point when compared to Baseline ERG. …”

Image_1_Assessment of Epigenetic and Phenotypic Variation in Populus nigra Regenerated via Sequential Regeneration.tif by Weixi Zhang (1626823)

“…We detected a significant difference in methylation levels between first regeneration regenerated plants (G1) and those of the other four generations (G2–G5); there were no significant differences among the four later generations. …”

microRNA-14 as an efficient suppressor to switch off ecdysone production after ecdysis in insects by Kang He (189002)

“…<p>The precise increase and decrease of hormone ecdysone are critical for accurate development in insects. …”

Conditional ablation of <i>Tra2b</i> causes perinatal lethality and disturbed cortical patterning in mice. by Markus Storbeck (191895)

“…Cells of the ventricular and subventricular zones of the cortex show strongest decrease in staining intensity (black arrowhead). Scale bar equals 400 µm; ctx, cortex; th, thalamus; cpt, caudoputamen; cp, cortical plate; iz, intermediate zone; svz, subventricular zone; vz, ventricular zone; sn, septal nuclei; 3v, third ventricle; lv, lateral ventricle; pc, choroid plexus.…”

Assessment of SnO2 nanoparticles' impact on local Pichoclorum atomus growth performance, cell morphology and metabolites content by Bounnit, Touria

“…The current study investigates the ecotoxicity of SnO2 nanoparticles on a local marine algae isolate. Five different concentrations (1, 5, 25, 50 and 100mg/L) were tested and the culture was followed for 72h. …”
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Ligand Substitutional Effects on Molecular Dynamics and Broadband Near-White Emission in 2D 2‑Fluoroethylammonium Cadmium Chlorobromide by Maciej Ptak (1713061)

“…Optical studies showed that ligand substitution causes narrowing in bandgap energy from 5.12 to 4.28 eV and triggering of white to yellow-green emission thermally quenched above 240 K.…”

Human MADD fibroblast cells display similar mitochondrial defects as <i>xav</i> mutants. by Yuanquan Song (238595)

“…The expression of ROS related genes are also altered in Patient 1, with a ca. 20% decrease in <i>catalase</i> and 4.7 and 5.7 fold increase in <i>glutathione reductase</i> and <i>HSPA9</i> expression (N = 3–7 replicates of cells from passage 7–12; Student's t test, * p<0.05, ** p<0.01, *** p<0.001).…”