Energetics of Ionized Water Molecules in the H‑Bond Network near the Ca²⁺ and Cl^– Binding Sites in Photosystem II by Keisuke Saito (516747)

“…It seems likely that Ca²⁺ plays a role in not only (i) maintaining the H-bond network and facilitating TyrZ oxidation [tuning <i>E</i>_m(TyrZ)] but also (ii) providing the valence of +2, decreasing the p<i>K</i>_a of the ligand molecule (W1), and facilitating the release of the proton from W1 in the S₂ to S₃ transition together with Cl^–.…”

Presentation 1_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

Presentation 3_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

Data Sheet 1_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

Data Sheet 2_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

Presentation 2_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi... by Gyeong Ho Baek (21382907)

“…Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …”

sAxl levels in relation to treatment outcomes. by Ioannis Parodis (2851211)

New [ONOO]-Type Amine Bis(phenolate) Ytterbium(II) and -(III) Complexes: Synthesis, Structure, and Catalysis for Highly Heteroselective Polymerization of <i>rac</i>-Lactide by Sheng Yang (592249)

“…Complex <b>5</b> is a THF-solvated monomer. Each six-coordinated Yb^III ion in both complexes adopts a distorted octahedron. …”

Probability of establishing a sylvatic ZIKV transmission cycle. by Benjamin M. Althouse (116177)

“…Contour lines show 0.25, 0.5, 0.75, and 0.95 probability of establishment. …”

Molecular interactions of agonist and inverse agonist ligands at serotonin 5-HT_2C G protein-coupled receptors: computational ligand docking and molecular dynamics studie... by Tania C. Córdova-Sintjago (597380)

“…<div><p>To understand molecular determinants for ligand activation of the serotonin 5-HT_2C G protein-coupled receptor (GPCR), a drug target for obesity and neuropsychiatric disorders, a 5-HT_2C homology model was built according to an adrenergic β₂ GPCR (β₂AR) structure and validated using a 5-HT_2B GPCR crystal structure. …”

Example entropy time series with a change of heart. by John H. Williamson (8917673)

“…There is a marked v shape to the curve as the decoder entropy increases after input starts to become incompatible with the original target <i>s</i>_<i>a</i>, and then decreases as sb is approached.…”

The α7 nAChR directly attenuates in EB3 entry into the growth cone. by Justin R. King (793933)

Serum Axl predicts histology-based response to induction therapy and long-term renal outcome in lupus nephritis by Ioannis Parodis (2851211)

“…Baseline sAxl levels decreased in CRs (<i>P</i> = 0.002) and HRs (<i>P</i><0.001), but not in non-responders; levels ≥36.6 ng/mL yielded a >5 times higher probability of histology-based response (odds ratio, OR: 5.5; 95% confidence interval, CI: 1.2–25.1). …”

Distribution of Total and Active RNA Polymerase II at Genes During the Transition from G1 to G2. by Douglas Maya-Miles (7024967)

Numerical evaluation of the thermal performance of a near-surface earth-to-air heat exchanger with short-grass ground cover: A parametric study by Pakari, Ali

“…By increasing the soil thermal conductivity from 1 to 5 W m−1 K−1 the outlet temperature decreased by about 4.4 °C.…”
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Altered Serum MicroRNAs as Novel Diagnostic Biomarkers for Atypical Coronary Artery Disease by Jun Wang (5906)

“…</p><p>Results</p><p>The TaqMan low density array and RT-qPCR analysis identified four serum miRNAs including miR-487a, miR-502, miR-208 and miR-215 that were significantly increased, while one miRNA, miR-29b, that was significantly decreased in ACAD patients compared with normal controls (<i>P</i><0.05). …”

Repetitive stress causes a reduction in neural contrast. by Ghattas Bisharat (20706928)

“…<p>(a) Mean pre- and post-sound activity presented as deconvolved spikes. …”

Mmp14a knockdown results in embryos with microphthalmic eyes. by Els Janssens (104451)

“…<p><b>A–D</b> Analysis of eye size (<b>A, C</b>) and total body length (<b>B, D</b>) reveals a dose-dependent decrease in eye size after knockdown of Mmp14a with the ATG- (<b>A, B</b>) or the splice MO (<b>C, D</b>) at 5 dpf. …”

Data_Sheet_1_An Upstream Open Reading Frame Represses Translation of Chicken PPARγ Transcript Variant 1.PDF by Yankai Chu (8503011)

“…Bioinformatics analysis showed that chicken PPARγ transcript 1 (PPARγ1) possessed an upstream open reading frame (uORF) in its 5′ UTR. Mutation analysis showed that a mutation in the uORF led to increased Renilla luciferase activity and PPARγ protein expression, but decreased Renilla luciferase and PPARγ1 mRNA expression. mRNA stability analysis using real-time RT-PCR showed that the uORF mutation did not interfere with mRNA stability, but promoter activity analysis of the cloned 5′ UTR showed that the uORF mutation reduced promoter activity. …”

Examination of mitochondrial function and cell viability in <i>PLA2G6</i>-KD cells. by Goichi Beck (818821)

“…<p>Each experiment was performed at least three times. (A) Generation of <i>PLA2G6-</i>KD gene SH-SY5Y cells. …”