Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer by Nafees Muhammad (5641151)

“…Cellular uptake and distribution studies reveal that <b>PFL</b> mainly accumulates in mitochondria. As a result, <b>PFL</b> disrupts the mitochondrial ultrastructure and induces significant alterations in the mitochondrial membrane potential, which further leads to an increase in production of reactive oxygen species (ROS) and a decrease in ATP synthesis in MDA-MB-231 TNBCs. …”

Table_1_Neural Activation During Tonic Pain and Interaction Between Pain and Emotion in Bipolar Disorder: An fMRI Study.DOCX by Xue Han (25073)

“…When experiencing pain, BPs showed a significant decrease in the BOLD signal in the bilateral insula, left inferior frontal gyrus (IFG), and left cerebellum as compared with HCs. …”

Image_2_The Effect of Drought on Transcriptome and Hormonal Profiles in Barley Genotypes With Contrasting Drought Tolerance.png by Amal Harb (9911961)

“…The major differences that emerged from the transcriptome analysis are; (1), the overall number of differentially expressed genes was relatively low in drought-tolerant Otis compared to drought-sensitive Baronesse; (2), a wax biosynthesis gene (CER1), and NAC transcription factors were specifically induced in Otis but not in Baronesse; (3), the degree of upregulation of betaine aldehyde dehydrogenase and a homeobox transcription factor (genes with proven roles in imparting drought tolerance), was greater in Otis compared to Baronesse; (4) the extent of downregulation of gene expression profiles for proteins of the reaction center photosystem II (PSII) (D1 and D2) was low in Otis compared to Baronesse; and, (5), alternative splicing (AS) was also found to differ between the genotypes under drought. …”

Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes by V.X. Farias (6800060)

“…On the other hand, the protein level of SMIT1 decreased by 42.5, 41.3, and 44.8% in the SN after 4, 8, and 12 weeks of diabetes, respectively. …”

Table_2_The Clinical Value of Procalcitonin in the Neutropenic Period After Allogeneic Hematopoietic Stem Cell Transplantation.docx by Meng Shan (7356113)

“…In multivariate analysis, the inability to decrease PCT by more than 80% within 5–7 days after the onset of fever independently predicted poor 100-day survival following allo-HSCT (P = 0.036). …”

Caesarean section association with chronic immune disorders by Maria Francetic (796315)

“…The frequencies of allergies are increasing in prevalence in countries around the world (specifically western countries) and has no specific identification of a source (5-6).One of the predominate theories explaining the correlation between CD and higher rates of asthma, obesity, allergens during childhood is the hygiene hypothesis, insinuating that the introduction and growth of microbial flora in the intestines during prenatal and postnatal development correlates to faster developing immune system which decrease probability of developing allergic diseases.…”

Table_1_Neuroimmune Pathophysiology in Asthma.pdf by Gandhi F. Pavón-Romero (5734610)

“…Moreover, the administration of experimental agents such as NK1R/NK2R antagonists and exogenous VIP decrease inflammatory mediators, suggesting that regulating the effects of NT/NP represents a potential novel approach for the treatment of asthma.…”

Diabetes induced iNOS expression and reduced Reg3β expression and ROS levels of the intestinal mucosa. by Wen-Chung Liu (5324606)

“…<i>plantarum</i> feeding decreased it. (C) STZDM mice induced a decrease of DCFDA levels in the intestinal mucosa compared with WT group, and FOS or dead <i>L</i>. …”

Did Vaccination Slow the Spread of Bluetongue in France? by Maryline Pioz (142655)

“…The average estimated velocity across the country despite restriction on animal movements was 5.4 km/day, which is very similar to the velocity of spread of the bluetongue virus serotype 8 epizootic in France also estimated in a context of restrictions on animal movements. …”

Effects of interleukin-10 receptor (IL-10R) blockade upon splenocytes of non-infected SJL mice. by Ann-Kathrin Uhde (3110976)

“…For gating strategy see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161883#pone.0161883.s003" target="_blank">S3 Fig</a>. …”

DataSheet_2_The Clinical Value of Procalcitonin in the Neutropenic Period After Allogeneic Hematopoietic Stem Cell Transplantation.xlsx by Meng Shan (7356113)

“…In multivariate analysis, the inability to decrease PCT by more than 80% within 5–7 days after the onset of fever independently predicted poor 100-day survival following allo-HSCT (P = 0.036). …”

M2 Macrophages Activate WNT Signaling Pathway in Epithelial Cells: Relevance in Ulcerative Colitis by Jesús Cosín-Roger (123861)

“…We also determined the mRNA expression of <i>Lgr5</i> and <i>c-Myc</i> by qPCR and protein levels of β-catenin by western blot. …”

Table_1_Grafting Watermelon Onto Pumpkin Increases Chilling Tolerance by Up Regulating Arginine Decarboxylase to Increase Putrescine Biosynthesis.XLSX by Junyang Lu (7846064)

“…<p>Low temperature is a major environmental factor that severely impairs plant growth and productivity. …”

Bax and Bcl-x_L are involved in the DHA-induced apoptosis. by Tongsheng Chen (394172)

“…<p>(A) Silencing of Bax but not Bak prevented DHA-induced decreasing of cell ability assessed by CCK-8. …”

Can Forest Management Practices Counteract Species Loss Arising from Increasing European Demand for Forest Biomass under Climate Mitigation Scenarios? by Francesca Rosa (3509216)

“…This outcome stems from a projected increase in EU forest biomass imports, partially from biodiversity-vulnerable regions to compensate for a decrease in domestic harvest. …”

Ext1^+/-Ext2^+/- mice show an abnormal MAP response after acute sodium loading. by Rik H. G. Olde Engberink (7109543)

“…<p>Control and Ext1^+/-Ext2^+/- mice were subjected to rapid 1.8% NaCl infusion, which was finished at t = 0 seconds. (A) Ext1^+/-Ext2^+/- (n = 5) and control mice (n = 6) showed a significant variation in intracarotid MAP response (Ext1^+/-Ext2^+/- vs control, p = 0.02): control mice had a significant 15±4% (p = 0.02) decrease in MAP, while MAP of Ext1^+/-Ext2^+/- mice did not change (3±6%, p = 0.65). …”

Design, Synthesis, and Biological Evaluation of New PDE4 Inhibitors for the Treatment of Pressure Ulcers by Xudong Qian (13182676)

Data_Sheet_1_WSV056 Inhibits Shrimp Nitric Oxide Synthase Activity by Downregulating Litopenaeus vannamei Sepiapterin Reductase to Promote White Spot Syndrome Virus Replication.doc... by Wei Wang (17594)

“…L. vannamei challenged with WSSV revealed a significant decrease in LvSpr transcription and Spr activity in hemocytes. …”

Can Forest Management Practices Counteract Species Loss Arising from Increasing European Demand for Forest Biomass under Climate Mitigation Scenarios? by Francesca Rosa (3509216)

“…This outcome stems from a projected increase in EU forest biomass imports, partially from biodiversity-vulnerable regions to compensate for a decrease in domestic harvest. …”

Protein Biomarkers and Risk Scores in Pulmonary Arterial Hypertension Associated with Ventricular Septal Defect: Integration of Multi-Omics and Validation by Chao Yuan (408257)

“…Proteomics (iTRAQ) identified 107 differential proteins (DPs) between patients with/without PAH including significantly increased ADIPO, DBH, ANPEP, TRF1, GP1BA and decreased GNAS in VSD-PAH. Metabolomics discovered 191 differential metabolites between patients with/without PAH including elevation of 5-HT, taurine, creatine, sarcosine, and 2-oxobutanoate and decrease of vanillylmandelic acid, 3,4-dihydroxymandelate, 15-Keto-PGF2, fructose-6-phosphate , L-glutamine, dehydroascorbate, hydroxypyruvate, threonine, L-cystine, and 1-aminocyclopropane-1-carboxylate. …”