IL-10^−/− mice demonstrate significantly reduced retinal neovascularization in response to ischemia. by Dru S. Dace (259377)

“…Fluorescent microscopy of perfused retinas of (A) normoxic-treated wild-type mice (n = 5), (B) oxygen-treated wild-type mice (n = 5), and (C) oxygen-treated IL-10^−/− mice (n = 4) reveal decreased angiogenesis and increased areas of non-perfusion in IL-10^−/− mice. …”

FoxO1 deacetylation couples Sirt1 action to POMC expression. by Işin Çakir (256194)

“…<p><i>(A)</i> Representative western blots showing the acetylation status of FoxO1 and Stat3 upon fasting and intraperitoneal leptin administration. 5 animals per group were evaluated. …”

Insulin secretion and mRNA assay in MIN6 cells after infection with equivalent titer of adenovirus. by Weina Gao (537908)

“…(A) MIN6 cells were treated with 0.5 µM thapsigargin (TG) or DMSO (vehicle control) for 1 h, 0.5 mM palmitate (PA) or 0.5% BSA (vehicle control) for 12 h, and the supernatants were assayed for insulin protein level (n = 3). …”

Temperature and precipitation change during 1951–2002. by Evan H. Girvetz (256065)

“…<p>Maps of the magnitude (left) and confidence (right) for annual mean temperature (top) and precipitation trends during 1951–2002 for each 0.5 degree grid cell in the CRU TS 2.1 data set <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008320#pone.0008320-Mitchell1" target="_blank">[10]</a>. …”

The functional effects of three novel human isoforms, GABAB1k, l, and m. by Changhoon Lee (360362)

“…After one-way ANOVA and Dunnett's tests, one-tailed unpaired Student's t-tests were performed between no isoform injected groups and the isoform injected groups. A. GABAB1k had no inhibitory effect. B. GABAB1l data showed significant differences by ANOVA and Dunnett's tests (p = 0.0058), and caused significantly decreased GIRK currents at 5× and 6× GABAB1l (**p = 0.0014 and *p = 0.0229, respectively). …”

Effect of Ang II and Zol on EPC <i>in vitro</i> tube formation ability. by Jin-Xiu Yang (128753)

“…B: Light micrographs showing typical tubules (200×). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046511#s3" target="_blank">Results</a> are the mean ± SD, n = 5. …”

<i>Tcf21</i> promoter mutagenesis analysis. by Ramji K. Bhandari (136008)

“…Bars with asterisks are significantly different from −0.5 kb control promoter. (B) Promoter activity decreased with the length of the promoter. …”

Deviation from the original expression profiles after probe filtering by Kyu-Baek Hwang (5187)

“…The mean correlation coefficient decreases as the minimum overlapping length increases. …”

The downregulation of Chk-α attenuated the phosphorylation levels of ERK1/2, AKT and mTOR. by Hoe Suk Kim (107279)

“…Data are presented as the mean ± standard deviation of 5 independent experiments. …”

Comparing the performance of different confocal light detectors across multiple instruments. by Dirk Dormann (480234)

“…<p>(A) Effect of frame averaging on the signal-to-noise ratio of the five detectors on a Leica confocal microscope. …”

Data_Sheet_1_Combined Carbon and Albedo Climate Forcing From Pine and Switchgrass Grown for Bioenergy.pdf by Benjamin J. Ahlswede (12539725)

“…We found that pine had a net positive radiative forcing (warming) of 5.4 ± 2.8 Wm⁻² when albedo and carbon were combined together (30 year mean). …”

PDGFRA surface expression is down-regulated by MEK inhibitor U0126. by Dongfeng Chen (405191)

“…MEK inhibitor U0126 decreased PDGFRA surface expression detected by FACS in cell line #2. …”

Measurement of lysosome proteolytic and acidic functions in response to PIKfyve inhibition and ROS. by Golam T. Saffi (11747438)

“…(D) RAW cells treated with vehicle or 20 nM apilimod for 40 min alone, or in combination with 1 μM rotenone for 60 min or 1 mM H₂O₂ for 40 min, and stained for LysoTracker Red as an indicator of lysosome acidification. Scale bar: 5 μm. (E) Quantification of mean lysotracker intensity per cell normalized to control cells. …”

DISTRIBUTION OF TRACE ELEMENTS IN TISSUES OF Goniopsis cruentata (LATREILLE, 1803) CAUGHT FROM SOUTH OF BAHIA/ BRAZIL MANGROVES AND POTENTIAL OF RISK ASSESSMENT IN CONSUMPTION by Luanna M. Carneiro (5887538)

“…The concentration of Mn in the females in the three estuaries studied was 1.5 to 4.2 times higher than in the males. In general, detected mean metal concentrations in crab tissues were (in decreasing order) gills > hepatopancreas > muscles. …”

IL-6 increases Oct-4 and telomerase expression in KPCs and SKPs. by Qunzhou Zhang (257627)

“…<p><i>A</i>, KPCs and SKPs were cultured in 1% FBS for 24 hours followed by exposure to different concentrations of IL-6, and BrdU incorporation in KPCs and SKPs was determined (mean±SEM). ** <i>P</i><0.01. …”

Human miR-583 downregulates NK cell differentiation. by Sohyun Yun (644307)

“…<p>(a) Differentiating cells were transfected with miR-143, a miR-583 mimic or negative control miRNA. …”

TGF-β1 increased Snail expression in cultured ARPE-19 cells. by Hui Li (32376)

“…<p>Total RNA was extracted from ARPE-19 cells at the time points as indicated after TGF-β1 (10 ng/ml) treatment. …”

Sketch of network connectivity reflecting lifelong structural plasticity. by Andreas Knoblauch (568277)

“…<p>During development anatomical connectivity (thick solid) quickly increases reaching a peak level (around 2–3y in humans), where the initial increase is followed by a short period of stable connectivity (until age 5y in humans), a phase of significant decrease of connectivity until puberty, and finally a phase of stable connectivity during adulthood <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096485#pone.0096485-Huttenlocher1" target="_blank">[14]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096485#pone.0096485-Elston1" target="_blank">[51]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096485#pone.0096485-Huttenlocher2" target="_blank">[77]</a>. …”

Plot of power for the adjusted test versus the unadjusted test at varying genetic risk levels by Laila M Poisson (73600)

The development of Panstrongylus herreri under fluctuating environmental conditions by Edson Franzim Junior (4680838)