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14501
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14502
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14503
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14504
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14505
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14506
Socioeconomic disparities and sexual dimorphism in neurotoxic effects of ambient fine particles on youth IQ: A longitudinal analysis
Published 2017“…Increased ambient PM<sub>2.5</sub> levels were associated with decreased IQ scores. …”
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14507
Aβ42-induced down-regulation of K<sub>v</sub>4 protein is mediated by a proteasome and lysosome-dependent pathway.
Published 2015“…The Aβ42-induced decrease in K<sub>v</sub>4 is blocked when brains were incubated with MG132 for 4 days. …”
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14508
Loss of intestinal epithelial Shh signaling leads to an increase in ER stress and a decrease in autophagy in intestinal epithelial cells (IECs).
Published 2014“…Western blot analysis against defensin 4, IRE1α, p62, lipidated LC3b-II and non-lipidated LC3b-I proteins were performed on ileal extracts from control and <i>Shh</i><sup>ΔIEC</sup> mice (E). Densitometry analysis of exposed films using ImageJ revealed a significant 3.85-fold decrease in defensin 4 expression (F) a significant 3.6-fold increase in IRE1α (G) and a significant 2.13-fold increase in p62 (H) in <i>Shh</i><sup>ΔIEC</sup> mice compared to controls (n = 3). …”
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14509
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14510
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14511
Predicting inadequate postoperative pain management in depressed patients: A machine learning approach
Published 2019“…The primary outcome was the difference between preoperative pain score and postoperative pain at discharge, 3-week and 8-week time points. We developed computational models to predict the increase or decrease in the postoperative pain across the 3 time points by using the patient’s EHR data (e.g. medications, vitals, demographics) captured before surgery. …”
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14512
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14513
Efficacy and Safety of Anti-Interleukin-5 Therapy in Patients with Asthma: A Systematic Review and Meta-Analysis
Published 2016“…Pooled analysis revealed significant improvements in FEV<sub>1</sub> (first second forced expiratory volume) (MD = 0.09, 95% CI: 0.06–0.12, <i>I</i><sup><i>2</i></sup> = 10%), FEV<sub>1</sub>% (MD = 3.75, 95% CI: 1.66–5.83, <i>I</i><sup><i>2</i></sup> = 19%), Asthma Quality of Life Questionnaire (AQLQ) score (MD = 0.22, 95% CI: 0.15–0.30, <i>I</i><sup><i>2</i></sup> = 0%), decreased blood, sputum eosinophils and asthmatic exacerbation (RR = 0.66, 95% CI: 0.59–0.73, <i>I</i><sup><i>2</i></sup> = 51%); peak expiratory flow (PEF) (MD = 5.45, 95% CI: -2.83–13.72, <i>I</i><sup><i>2</i></sup> = 0%), histamine PC<sub>20</sub> (MD = -0.62, 95% CI: -1.92–0.68, <i>I</i><sup><i>2</i></sup> = 0%) or SABA rescue use (MD = -0.11, 95% CI: -0.3–0.07, <i>I</i><sup><i>2</i></sup> = 30%) were unaffected; adverse events were not increased (RR = 0.93, 95% CI: 0.89–0.98, <i>I</i><sup><i>2</i></sup> = 46%). …”
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14514
A Review of Recent Research on Catalytic Biomass Pyrolysis and Low-Pressure Hydropyrolysis
Published 2021“…This review summarizes the myriad of different catalysts studied and benchmarks their deoxygenation performance by also taking into account the resulting decrease in bio-oil yield compared to a thermal pyrolysis oil. …”
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14515
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14516
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14517
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14518
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14519
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14520
Image3_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.TIF
Published 2024“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”