Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Even a Chronic Mild Hyperglycemia Affects Membrane Fluidity and Lipoperoxidation in Placental Mitochondria in Wistar Rats - Fig 6 by María del Consuelo Figueroa-García (832711)

Bald thigh syndrome in sighthounds—Revisiting the cause of a well-known disease by Magdalena A. T. Brunner (4532341)

“…Further research is required to clarify whether the <i>IGFBP5</i> variant represents a predisposing genetic risk factor. …”

Microarray analysis of genes downregulated in 16E6 HFKs with increased NFX1-123. by Justine Levan (4579156)

“…(D) Venn diagram of genes whose average expression was decreased at least two-fold in 16E6/FN123 cells compared to 16E6/control. …”

Comparison of the time course of the SARS-CoV-2 pandemic up to 7 November 2020 for the seven regions in England for the time-varying IFR model between using death within 28 days of... by Siyu Chen (278663)

Synthesis, Crystal Structure, and Spectroscopic Characterization of a Series of Cubane-like Mo−Sb Clusters Containing a [Mo₃SbOS₃]⁷⁺ Core by Shao-Fang Lu (2974926)

“…Crystal data:  <b>1</b>, triclinic, <i>P</i>-1, <i>a</i> = 11.746(4) Å, <i>b</i> = 12.462(3) Å, <i>c</i> = 17.851(6) Å, α = 73.54(2)°, β = 75.06(3)°, γ = 88.11(3)°, <i>V</i> = 2419(3) ų, <i>Z</i> = 2, 4253 reflections, <i>R</i> = 0.055; <b>2</b>, triclinic, <i>P</i>-1, <i>a</i> = 12.76(1) Å, <i>b</i> = 17.86(1) Å, <i>c</i> = 11.882(4) Å, α = 75.05(4)°, β = 88.15(7)°, γ = 73.24(4)°, <i>V</i> = 2502(6) ų, <i>Z</i> = 2, 1849 reflections, <i>R</i> = 0.086; <b>3</b>, triclinic, <i>P</i>-1, <i>a</i> = 11.727(4) Å, <i>b</i> = 12.951(3) Å, <i>c</i> = 17.957(4) Å, α = 73.52(3)°, β = 76.22(3)°, γ = 89.00(2)°, <i>V</i> = 2536(3) ų, <i>Z</i> = 2, 6306 reflections, <i>R</i> = 0.053; <b>5</b>, triclinic, <i>P</i>-1, <i>a</i> = 13.261(4) Å, <i>b</i> = 13.529(4) Å, <i>c</i> = 12.535(8) Å, α = 101.54(3)°, β = 105.13(4)°, γ = 93.20(2)°, <i>V</i> = 2113(2) ų, <i>Z</i> = 2, 4104 reflections, <i>R</i> = 0.060.…”

Ligand destabilizing native closed loop rescues misfolded CAT-III. by Yang Jiang (46459)

a-e. Effects of physical activity on clinical performance. by Vjera A. Holthoff (351112)

“…<p>This figure shows the effects of physical activity on the patients when compared to the control group for the three time points (T0- baseline, T1–3 months later or after completion of the intervention and T2- 3 month follow-up). …”

A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country by Zaghloul, Nancy

Get full text
Get full text

Image_4_Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.tif by Pamela E. Rodriguez (13862276)

“…Here, we evaluated the longitudinal humoral response and neutralising capacity in plasma samples of volunteers vaccinated with different platforms (Sputnik V, BBIBP-CorV, and AZD1222). A cohort of 851 participants, mean age 83 (60-103 years), from the province of Buenos Aires, Argentina were included. …”

Image_2_Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.tif by Pamela E. Rodriguez (13862276)

“…Here, we evaluated the longitudinal humoral response and neutralising capacity in plasma samples of volunteers vaccinated with different platforms (Sputnik V, BBIBP-CorV, and AZD1222). A cohort of 851 participants, mean age 83 (60-103 years), from the province of Buenos Aires, Argentina were included. …”

Image_1_Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.tif by Pamela E. Rodriguez (13862276)

“…Here, we evaluated the longitudinal humoral response and neutralising capacity in plasma samples of volunteers vaccinated with different platforms (Sputnik V, BBIBP-CorV, and AZD1222). A cohort of 851 participants, mean age 83 (60-103 years), from the province of Buenos Aires, Argentina were included. …”

Image_3_Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.tif by Pamela E. Rodriguez (13862276)

“…Here, we evaluated the longitudinal humoral response and neutralising capacity in plasma samples of volunteers vaccinated with different platforms (Sputnik V, BBIBP-CorV, and AZD1222). A cohort of 851 participants, mean age 83 (60-103 years), from the province of Buenos Aires, Argentina were included. …”

Photographs of the left eye 5 years (A–D) and 8 years (E) after systemic corticosteroid therapy in a patient shown in Fig 2. by Saho Saito (731215)

Image_5_Thermal preconditioning in a reef-building coral alleviates oxidative damage through a BI-1-mediated antioxidant response.jpeg by Eva Majerová (13895703)

Image_5_Phosducin-like 3 is a novel prognostic and onco-immunological biomarker in glioma: A multi-omics analysis with experimental verification.tif by Zesheng Peng (14792245)

Table_5_Phosducin-like 3 is a novel prognostic and onco-immunological biomarker in glioma: A multi-omics analysis with experimental verification.xlsx by Zesheng Peng (14792245)