Utilizing CMP-Sialic Acid Analogs to Unravel <i>Neisseria gonorrhoeae</i> Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics by Sunita Gulati (451977)

“…<div><p><i>Neisseria gonorrhoeae</i> deploys a novel immune evasion strategy wherein the lacto-N-neotetraose (LNnT) structure of lipooligosaccharide (LOS) is capped by the bacterial sialyltransferase, using host cytidine-5’-monophosphate (CMP)-activated forms of the nine-carbon nonulosonate (NulO) sugar <i>N</i>-acetyl-neuraminic acid (Neu5Ac), a sialic acid (Sia) abundant in humans. …”

A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth -4 by Vinay Bhaskar (85020)

“…<p><b>Copyright information:</b></p><p>Taken from "A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth "</p><p>http://www.translational-medicine.com/content/5/1/61</p><p>Journal of Translational Medicine 2007;5():61-61.…”

The amplitude of correlation coefficients decreases under subsampling, whereas the intrinsic timescale <i>τ</i> and the branching parameter <i>m</i> (characterized by the slope of... by F. P. Spitzner (10725103)

Dynamics and structural stability effects of germline <i>PTEN</i> mutations associated with cancer versus autism phenotypes by Iris Nira Smith (5215259)

“…We demonstrate structural stability changes where all six cancer-associated mutations showed a global decrease in structural stability and increased dynamics across the domain interface with a proclivity to unfold, mediating a closed (inactive) active site. …”

Supplementary Material for: TGF-β1 inhibition of ACE2 mediated by miRNA uncovers novel mechanism of SARS-CoV-2 pathogenesis. by Hejenkowska E.D. (16821483)

Drug repositioning against COVID-19: a first line treatment by Nousheen Bibi (446289)

“…Further through molecular dynamics simulation, critical conformational changes in the target protein molecules were revealed upon drug binding which illustrates the favorable binding conformations of antiviral drugs against SARS-CoV-2 target proteins. The resulting drugs from the present study in combination and in cocktails from the arsenal of existing drugs could reduce the translational distance and could offer substantial clinical benefit to decrease the burden of COVID-19 illness. …”

Sequential infection does not alter relative proportions of white blood cells. by Yuhao Li (1559569)

Pirfenidone for Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis by Carlos Aravena (787791)

“…Also there was a decrease in progression free survival (PFS) (RR 0.83 IC 0.74–0.92) compared to placebo. …”

Effects of glycosylation on V1V2 peptide region in the context of the BG505 Env trimeric spike. by Jianhui Tian (383833)

“…<p><b>(A)</b> Root mean square fluctuation of the backbone atoms corresponding to residues 129–134 and 152–184 (HBX2 numbering) and computed for either the glycosylated (black line) and non-glycosylated (red line) protein. …”

Data Sheet 1_SARS-CoV-2 Nsp7 plays a role in cognitive dysfunction by impairing synaptic plasticity.docx by Jiazheng Guo (14799721)

“…Initially, we confirmed a reduction in the level of synaptic proteins in SH-SY5Y neurons following SARS-CoV-2 infection. …”

Simultaneously Enhancing Mechanical Strength, Toughness, and Fire Retardancy of Biobased Polyurethane by Regulating Soft/Hard Segments and Crystallization Behavior by Weijun Yang (560411)

“…Furthermore, the LOI value of FRBPU-0.5P reached 29.6%, and this material achieved a UL-94 V-0 rating. …”

Simultaneously Enhancing Mechanical Strength, Toughness, and Fire Retardancy of Biobased Polyurethane by Regulating Soft/Hard Segments and Crystallization Behavior by Weijun Yang (560411)

“…Furthermore, the LOI value of FRBPU-0.5P reached 29.6%, and this material achieved a UL-94 V-0 rating. …”

Simultaneously Enhancing Mechanical Strength, Toughness, and Fire Retardancy of Biobased Polyurethane by Regulating Soft/Hard Segments and Crystallization Behavior by Weijun Yang (560411)

“…Furthermore, the LOI value of FRBPU-0.5P reached 29.6%, and this material achieved a UL-94 V-0 rating. …”

Simultaneously Enhancing Mechanical Strength, Toughness, and Fire Retardancy of Biobased Polyurethane by Regulating Soft/Hard Segments and Crystallization Behavior by Weijun Yang (560411)

“…Furthermore, the LOI value of FRBPU-0.5P reached 29.6%, and this material achieved a UL-94 V-0 rating. …”

Fig 4 - by Chengyu Wu (640314)

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The combination of indisulam and melphalan inhibits MM cell proliferation and induces cell apoptosis and DNA damage. by Chengyu Wu (640314)

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Fig 1 - by Chengyu Wu (640314)

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Combinatorial treatment delays MM growth in vivo. by Chengyu Wu (640314)

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Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect by Tzu-Chun Chen (787255)

“…However, the abundance of HCV RNA carrying mutations on both miR-122-binding sites and whose stability was supported by ectopically expressed miR-122 mimetics with compensatory mutations also decreased in Rab27a-depleted cells. This result indicates that the effect of Rab27a depletion on HCV RNA abundance does not depend on the formation of 5’ terminal HCV/miR-122 RNA complexes, but that miR-122 has a Rab27a-dependent function in the HCV lifecycle, likely the downregulation of a cellular inhibitor of HCV gene expression. …”

LA is a more potent inhibitor of HIV-1 virion-associated RT activity compared to acetic acid or low pH (HCl) alone. by Muriel Aldunate (22411177)