A Randomized, Placebo Controlled, Double Masked Phase IB Study Evaluating the Safety and Antiviral Activity of Aprepitant, a Neurokinin-1 Receptor Antagonist in HIV-1 Infected Adul... by Pablo Tebas (27720)

“…<div><h3>Background</h3><p>Neurokinin-1 receptor (NK1R) antagonists have anti-HIV activity in monocyte-derived macrophages, decrease CCR5 expression and improve natural killer cell function <em>ex vivo</em>. …”

Related to Fig 4. <i>NDUFS7</i> depletion in neurons lowers the failure rate of neurotransmission at very low calcium concentrations. by Bhagaban Mallik (12459375)

“…The number of failures was counted per hundred trials in each genotype. There is a marked decrease in failure rate in motor neurons driving <i>UAS-NDUFS7[RNAi]</i>. …”

Down-regulation of the <i>cwp</i> genes in cells expressing the <i>luciferase</i> gene with a nonsense mutation. by Yi-Hsiu Chen (375991)

“…(B) Nonsense mutation leads to a decrease of luciferase activity. After stable transfection with the pPT5 and pPT5m constructs, luciferase activity was measured in vegetative cells. …”

Table_1_Associations Between CAMKK1 Polymorphism rs7214723 and the Prognosis of Patients With Lung Cancer.docx by Haorui Zhang (6751946)

“…TT + TC: adjusted hazard ratio = 0.78, 95% confidence interval [CI], 0.61-1.00, P = 0.049) than the TT + TC genotypes. Stratified analysis showed that the CAMKK1 rs7214723 CC genotype and recessive CC genotype conferred a significantly decreased risk of death in patients who were male, had a smoking history, or had stage III + IV cancer, compared with the TT and TT + TC genotypes. …”

Rates of heat loss in solitary and aggregated night lizards. by Alison R. Davis Rabosky (149540)

“…Properties of each curve are represented by single points in panels B–D. (<b>B</b>) Thermal decay time (two half-lives) for solitary lizards increases with mass (F_1,51 = 5.07, <i>P</i> = 0.029). …”

Temporomandibular disorder, body pain and systemic diseases: assessing their associations in adolescents by Guilherme Vinícius do Vale BRAIDO (10409662)

“…Conclusion The findings of this study point out the importance of considering the presence of comorbid conditions in the diagnosis and management of painful TMD in adolescents. …”

Lithiation-Induced Embrittlement of Multiwalled Carbon Nanotubes by Yang Liu (4829)

“…Upon lithiation, the intertube spacing increased from 3.4 to 3.6 Å, corresponding to about 5.9% radial and circumferential expansions and ∼50 GPa tensile hoop stress on the outermost tube wall. …”

Chronic intermittent ethanol (CIE) exposure alters the time course of STDP. by Sven Kroener (321008)

“…This was due both to a decrease in potentiation at the late time-point and to the continued increase in LTP in both CIE-exposed groups of mice. …”

Data_Sheet_1_Identification of a New de Novo Mutation Underlying Regressive Episodic Ataxia Type I.DOCX by Zeynep S. Karalok (5556416)

“…The conserved glycine is located in the S4–S5 linker, a crucial domain controlling Kv1.1 channel gating. …”

Lithiation-Induced Embrittlement of Multiwalled Carbon Nanotubes by Yang Liu (4829)

“…Upon lithiation, the intertube spacing increased from 3.4 to 3.6 Å, corresponding to about 5.9% radial and circumferential expansions and ∼50 GPa tensile hoop stress on the outermost tube wall. …”

Platelet thrombus formation on collagen surface in the presence of Hb. by Gowtham K. Annarapu (2622811)

“…<p><b>(A)</b> Whole blood was perfused over immobilized collagen type-1 (100 μg/mL) under shear stresses of 5 and 25 dyne/cm² in the presence of Hb. …”

IP3Rs localization and function. by Ilanit Itzhaki (225708)

“…(<b>E–F</b>) Dose-response curves displaying the effects of 2-APB (0.1, 0.5, 1, 2, 5 and 10 µM) (E) and U73122 (0.5, 1, 2 and 3 µM) (F) on whole-cell [Ca²⁺]_i transients amplitude (displayed as the relative decrease (%) versus baseline values). …”

Subcutaneous transplantation of L23 cells in the ear induce fast rejection and reduced proliferative response of draining lymph node cells. A: by Lilli Kraus (302769)

“…Lymphocytes were (re-)stimulated with 2×10³ irradiated L23 cells for 5 days. Comparison of proliferative response showed a decrease of ³H thymidin incorporation in draining lymph nodes. …”

Assessment of oscillatory potential (OP) amplitude profiles. by Jake Bedore (777372)

“…Quantification of summed OP amplitude for the four OPs measured over the four largest stimulus strengths (0.63–25 cd˖s /m²) under scotopic conditions measured shows a significant decrease in VAChT^{Six3-Cre-flox/flox} retinas (open circles) relative to littermate controls (VAChT^flox/flox, closed squares) at (I) 5 (n = 7 VAChT^{Six3-Cre-flox/flox} and n = 12 littermate control) and (J) 12 months of age (n = 5 VAChT^{Six3-Cre-flox/flox} and n = 5 littermate control). …”

Effects of site-specific sustained photostimulation of inhibitory neurons within the pre-Bötzinger complex <i>in situ</i>. by Jessica Ausborn (5147210)

“…(<b>D</b>) Summary data (n = 10, mean ± SEM, **p<0.01, *p<0.05) of bilateral pre-BötC photostimulation shows that relatively weak (0.5–2.0 mW) stimulation significantly increased respiratory frequency in a laser power-dependent manner, and stronger (4.0–5.0 mW) stimulation caused a decrease of inspiratory frequency with complete termination of inspiratory activity for the stimulus duration at the maximum laser power (5.0 mW).…”

LPO substrate specificity and susceptibility map of influenza strains. by Urmi Patel (5558513)

“…The X axis shows susceptibility against OSCN^- while the Y axis shows susceptibility towards OI^-. Mean+/-S.E.M. for both, X and Y axes, n = 2–5. The indicated diagonal crossing on the map from the lower left corner to the upper right corner indicates no substrate preference, irrespective of susceptibility. …”

Blocked NF-κB activation inhibits cytokine-upregulated IgSF molecules expression, and MSC modulates cytokine-induced NF-κB nuclear translocation. by Li Wen (169316)

“…<p>A to C shows FCM analysis of HCE-T cells treated with BMS-345541 (5 µM), a NF-κB pathway inhibitor, significantly inhibited IFN-γ (100 U/ml) and TNF (100 U/ml) induced ICAM-1 (A), HLA-ABC (B), and HLA-DR (C) expression. …”

Characteristics induced by 2 weeks exposure of SRA01/04 cells to low-doses of H₂O₂. by Zi-Feng Zhang (341807)

“…<p>A. Shows that cell viability (Left) of SRA01/04 cells decreases with increasing concentrations of H₂O₂ as measured by the MTT assay (Mean± SD; n = 5.). …”

Effect of convergence criterion on overall solution accuracy. by Christian Schlinkmann (9585315)

“…At 6% error a value of 1.0×10⁻⁵ already gives a good approximation of the final solution, with the overall error stabilizing at 3.7% for a value of 1.0×10⁻⁷. b) Mean relative error of the displacements as a function of simulation time, using no additional levels of detail and 1.0×10⁻⁷ as convergence criterion. c) Relative error of the maximum displacement in an analytical example consisting of a steel beam with a compressive load applied parallel to the longest axis. …”

Strong interdependence generates communities that are robust to variation in initial conditions. by Sylvie Estrela (156401)

“…An increment in initial segregation of 0.1 means a 5% increase (or decrease) in the number of cells of species A (or species B) inoculated in each microcolony. …”